Loading...
  • epidermal growth
  • It serves as a receptor for the epidermal growth factor (EGF) family of growth factors. (perkinelmer.de)
  • When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. (nih.gov)
  • Mutations of epidermal growth factor receptor and erbB-2 mRNAs were detected in endometrial cancer, which with mutated ER might contribute to a part of development and growth of this tumor (Eur.J.Gynecol.Oncol. (nii.ac.jp)
  • A new bispecific ligand-directed toxin (BLT) was created in which 2 human cytokines-epidermal growth factor ([EGF], targeting overexpressed EGF receptor) and amino acid terminal fragment ([ATF], targeting urokinase plasminogen activator receptor)-were cloned onto the same single-chain molecule with truncated Pseudomonas exotoxin with a terminal lysyl-aspartyl-glutamyl-leucine (KDEL) sequence. (thejns.org)
  • Here, we contrasted these two models of ErbB-2 function: First, examination of a large series of epidermal growth factor (EGF)-like ligands and neuregulins, including virus-encoded ligands as well as related motifs derived from the precursor of EGF, failed to detect interactions with ErbB-2 when this protein was singly expressed. (uptodate.com)
  • Cell Proliferation
  • These receptors are involved in cell signaling pathways that cause increased cell proliferation, cell motility, and cell survival ( 2 , 3 ). (aacrjournals.org)
  • Enhancing β-cell proliferation is a major goal for type 1 and type 2 diabetes research. (diabetesjournals.org)
  • The roles of vascular endothelial growth factor (VEGF) and its receptors as important mediators in endothelial cell proliferation, migration, invasion, and differentiation during angiogenesis have been well established ( 4 ). (aacrjournals.org)
  • metabolism
  • Eighteen genes regulating metabolism of fatty acids, lipid second messengers and gangliosides were 2-9 fold upregulated in melanomas of GDS-1375. (cancerindex.org)
  • pathway
  • Mike Nickerson ( nickersonml@mail.nih.gov ) included negative feedback to IRS1 and 2 from the PI3 kinase pathway. (cancer.gov)