• genes
  • ii) selected P2 receptors genes were silenced via specific small interfering RNAs. (fraunhofer.de)
  • We have previously shown that deletion of the Gja1 gene alters expression levels of numerous genes encoding proteins with diverse functions, including purinergic receptors (P2Rs), and have found that genes synergistically or antagonistically expressed in wild-type tissues are more prone to be similarly or oppositely regulated in Cx43-nulls. (ad-astra.ro)
  • Our findings indicate that, in brain and in cultured astrocytes, several of these coexpressed genes encode proteins that are components of P2R signal-transduction pathways and/or directly interact with these receptors, including the gap junction protein connexin43 (Cx43) and Cx45 as well as pannexins. (ad-astra.ro)
  • whereas
  • These actions of EK were antagonized by naloxone and completely reversed by prior treatment of the cells with pertussis toxin, whereas the toxin hardly affected the actions of P2-agonists and bradykinin themselves. (biochemj.org)
  • approaches
  • Current research in this area is directed toward the identification and structural characterization of these receptors by biochemical and molecular biological approaches. (nih.gov)