• The GPCRdb database is the main repository of curated data for G protein-coupled receptors (GPCRs). (wikipedia.org)
  • G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. (nih.gov)
  • https://commonfund.nih.gov/idg/index ) is to solicit applications for pilot projects on IDG-eligible understudied proteins (non-olfactory GPCRs, protein kinases, and ion channels) in order to study them beyond what the IDG's Centers can accomplish and to validate and demonstrate the utility of IDG-generated reagents, data, and approaches. (nih.gov)
  • G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively. (elifesciences.org)
  • We further demonstrate that topology of CCR5 (CC chemokine receptor type 5), one of the GPCRs containing this motif, is inverted through RAT in lipopolysaccharides (LPS)-stimulated macrophages. (elifesciences.org)
  • This analysis revealed that ~100 transmembrane proteins, most of which are GPCRs, met our searching criteria ( Table 1-source data 1 ). (elifesciences.org)
  • This funding opportunity announcement (FOA) aims to promote innovative research across multiple disciplines to increase knowledge of understudied non-olfactory G protein-coupled receptors (GPCRs), ion channels, and protein kinases. (nih.gov)
  • Neuronal G-protein-coupled receptors (GPCRs) play important roles in many aspects of brain function. (jneurosci.org)
  • G protein-coupled receptors (GPCRs) are a diverse super family of seven transmembrane spanning proteins whose primary function is to initiate the activation of intracellular signalling pathways following stimulation by extracellular stimuli, which include photons, amines, lipids, ions, peptides and proteins. (bl.uk)
  • We overexpress, solubilize, stabilize and purify our GPCRs with our patented technologies , so we can offer you the highest quality proteins. (calixar.com)
  • GPCRs are specific to a wide range of ligands, including photons, small molecules, and proteins. (calixar.com)
  • Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins. (calixar.com)
  • The G protein-coupled receptors (GPCRs) constitute a large and ancient superfamily of integral cell membrane proteins that play a central role in signal transduction and are activated by an equally diverse array of ligands. (rupress.org)
  • GPCRs share a seven hydrophobic α-helical domain structure and transduce signals through coupling to guanine nucleotide-binding regulatory proteins (G proteins). (rupress.org)
  • We have identified 100 genes in the Drosophila genome that code for putative neurotransmitter and hormone GPCRs and atypical seven-transmembrane domain (7 TM) proteins, 68 of which are described here for the first time ( Fig. 1 , red). (rupress.org)
  • Despite the greater number and diversity of GPCRs in vertebrates and C. elegans as compared with Drosophila , the data point to conservation of hormone and neurotransmitter receptors across phyla, suggesting ancient evolutionary origins. (rupress.org)
  • Common mechanisms that may contribute to protection against self-propagating protein conformations include blocking the entry of protein "seeds" to cells, clearance of immune complexes by microglia, and the intracellular protein degradation pathway initiated by cytoplasmic antibodies via the Fc receptor TRIM21. (frontiersin.org)
  • Heat shock proteins (HSP) are intracellular molecular chaperones of naive proteins, which are induced in response to stressful conditions. (physiciansweekly.com)
  • An active G protein can induce various intracellular messenger cascades, allowing the regulation of an incredible array of functions in the human body. (calixar.com)
  • Epac and PKA: a tale of two intracellular cAMP receptors. (nih.gov)
  • It integrates various web tools and diagrams for GPCR analysis and stores manual annotations of all GPCR crystal structures made available through the PDB (Protein Data Bank), has the largest collections of receptor mutants and reference sequence alignments. (wikipedia.org)
  • It crosslinks to the GuideToPharmacology database and has adopted the official NC-IUPHAR receptor naming nomenclature, has exchange with GPCR servers, and has also recently become part of the GPCR Consortium set out to generate an unprecedented number of crystal structures. (wikipedia.org)
  • Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. (nih.gov)
  • There is substantial evidence for an M 1 mACh receptor population in the hippocampus and in particular a potential role of this GPCR subtype in mechanisms underlying longer-term regulation of synaptic function. (jneurosci.org)
  • In summary, the experiments described in this thesis reveal that human and mouse islets exhibit some degree of similarity in GPCR and GPCR peptide ligand mRNA expression, but the suitability of using mouse islets as surrogates for predicting human islet physiology is receptor/receptor family specific. (bl.uk)
  • CALIXAR's Membrane Protein GPCR targets listed below, are continuously being optimized in our laboratories and are already available for purchase from our expanding catalog. (calixar.com)
  • Use CALIXAR's high-quality Membrane Protein GPCR Target - Adenosine receptor A2A (AA2AR) for impeccable drug discovery, development, and antibody assays. (calixar.com)
  • Use CALIXAR's Membrane Protein GPCR Target - Melatonin receptor type 1A (Mel-1A-R) for unimpaired antibody discovery, and pharmaceutical assays. (calixar.com)
  • What are calixar's membrane protein gpcr targets? (calixar.com)
  • G protein-coupled receptors (GPCR) are one of the largest families of integral membrane proteins. (calixar.com)
  • As the name suggests, the binding of an agonist to the GPCR receptor results in the recruitment and activation of the G protein, or of other transducers like arrestins. (calixar.com)
  • CALIXAR provides native Membrane Protein GPCR Targets in full-length form, and without mutation. (calixar.com)
  • CALIXAR's Membrane Protein GPCR Targets can be used to develop and test new and innovative drugs . (calixar.com)
  • Who are calixar's membrane protein gpcr targets ideal for? (calixar.com)
  • What are our clients able to do thanks to calixar's membrane protein gpcr targets? (calixar.com)
  • Ferguson, 2001 ), brought about by GRKs (G-protein-coupled receptor kinases) and second-messenger-regulated kinases, respectively. (jneurosci.org)
  • A series of tools made available in the homepage for the GPCRdb can be run in the web browser to analyze structures, sequence similarities, receptor relationships, homology models, drug trends, genetic variants and ligand target profiles. (wikipedia.org)
  • Approaches to increase affinity of the carbohydrate ligand include structural modification of the binding site and introduction of multivalency of binding sites by artificial linkages to carriers such as proteins or carbohydrates. (europa.eu)
  • It may function to prevent ligand binding of receptors during protein processing events within endosomal compartments. (harvard.edu)
  • Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. (harvard.edu)
  • Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. (harvard.edu)
  • Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be. (elifesciences.org)
  • When the receptor is activated by an agonist, its conformation is altered in a ligand-dependent manner, triggering specific modulation and activation of G proteins in the cell. (calixar.com)
  • This study examines how neutralization of \(E^{3.49/6.30}\) in the thromboxane prostanoid (TP) receptor alters ligand binding, basal, and agonist-induced activity and investigates the molecular mechanisms of G protein activation. (uni-wuerzburg.de)
  • Ligand-gated channels (such as those found in nicotinic receptors) are not suitable for this because the channels close in milliseconds. (cdc.gov)
  • Of the multiple proteins that transiently interact with AMPARs and that determine their trafficking, synaptic targeting and recycling in neurons, some special attention must be given to transmembrane proteins that form integral part of the functional receptor. (frontiersin.org)
  • We have recently analyzed the topology of a transmembrane protein called TM4SF20 (transmembrane 4 L6 family member 20). (elifesciences.org)
  • To search for other proteins that may undergo RAT, we performed a bioinformatics analysis to identify proteins that contain a GXXXN motif in their first transmembrane helix. (elifesciences.org)
  • The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. (elifesciences.org)
  • Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane. (nih.gov)
  • Triple negative breast cancers (TNBC) are typically more aggressive and result in poorer outcomes than other breast cancers because treatment options are limited due to lack of hormone receptors or amplified HER2. (nih.gov)
  • All breast cancers are tested for hormone receptors (proteins). (cancer.org)
  • Read more at Breast Cancer Hormone Receptor Status . (cancer.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • The overall goal of the IDG Program is to catalyze research in areas of biology that are currently understudied but that have high potential to impact human health by (1) identifying biochemical, cellular, or animal model phenotypes for understudied proteins from druggable gene families, (2) enabling further investigation of those proteins by providing reagents and tools, and (3) generating, maintaining, and facilitating the use of a minable knowledge base. (nih.gov)
  • This gene encodes a melanocortin receptor-interacting protein. (nih.gov)
  • Simmonds, R. E. & Lane, D. A. Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex α1 and α2 domains. (nature.com)
  • The protein encoded by P2RY8 gene is composed of 359-amino acids and belongs to the P2Y family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. (atlasgeneticsoncology.org)
  • LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. (harvard.edu)
  • gene knock-out by homologous recombination has provided evidence for an involvement of these GRKs in muscarinic acetylcholine (mACh) receptor and dopamine receptor regulation in vivo , respectively. (jneurosci.org)
  • Many TNBCs overexpress the epidermal growth factor receptor (EGFR) or manifest amplification of the EGFR gene, supporting EGFR as a therapeutic target. (nih.gov)
  • The ADGRE2 gene provides instructions for making a protein found in several types of immune system cells, including mast cells. (medlineplus.gov)
  • The ADGRE2 gene mutation that causes vibratory urticaria, written as Cys492Tyr or C492Y, replaces the protein building block (amino acid) cysteine with the amino acid tyrosine at position 492 of the protein sequence. (medlineplus.gov)
  • If it is not clear how much HER2 protein is present, molecular testing might be done to see how many copies of the HER2 gene the cancer cells have. (cancer.org)
  • For more information about the HER2 gene and protein see Breast Cancer HER2 Status . (cancer.org)
  • Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). (uwo.ca)
  • During viral evolution, HHVs have pirated genes encoding viral G protein-coupled receptors (vGPCRs), which are expressed on infected host cells. (nih.gov)
  • The genes encoding LAIR-1 are found on the leukocyte receptor on human chromosome 19. (prospecbio.com)
  • More than 700 genes are identified as G-protein coupled receptors. (calixar.com)
  • Muscarinic acetylcholine receptors - like nicotinic receptors - are proteins that extend through the cell membrane from the outside to the inside. (cdc.gov)
  • A membrane protein found in the rough endoplasm reticulum (ENDOPLASMIC RETICULUM, ROUGH) that binds to LDL-RECEPTOR RELATED PROTEINS. (harvard.edu)
  • We show that APP binds the Wnt ligands Wnt3a and Wnt5a and that this binding regulates APP protein levels. (elifesciences.org)
  • HSP is released into the extracellular milieu and binds to Toll-like receptors (TLRs) to regulate immune responses, such as cytokine and chemokine release. (physiciansweekly.com)
  • Approach and Results-Fibrillin-1 and elastin are the major components of elastic fibers, and fibrillin-1 binds bone morphogenetic proteins (BMPs) and the large latent complex of transforming growth factor-beta 1 (TGF beta 1). (uni-koeln.de)
  • The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
  • Inhibition of endogenous GRK6 (G-protein-coupled receptor kinase) activity, by the introduction of catalytically inactive K215R GRK6, partially reversed the attenuation of agonist-induced responsiveness, whereas overexpression of wild-type GRK6 increased receptor desensitization. (jneurosci.org)
  • Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. (jefferson.edu)
  • KISS1R signaling promotes drug resistance by increasing the expression of efflux drug transporter, breast cancer resistance protein (BCRP) and by inducing the activity and transcription of the receptor tyrosine kinase, AXL. (uwo.ca)
  • In the present study, we investigated the nature and the importance of glycosylation of two mammalian bombesin receptors, the neuromedin B receptor (NMB-R) and the gastrin-releasing peptide receptor (GRP-R), using chemical cross-linking and enzymatic deglycosylation. (nih.gov)
  • There are eight mammalian P2Y receptors known to date ( P2Y1 , P2Y2 , P2Y4 , P2Y6 , P2Y11 , P2Y12 , P2Y13 and P2Y14 ) and they are found in most human tissues. (atlasgeneticsoncology.org)
  • BPS Bioscience Inc. specializes in mammalian expression system to produce recombinant proteins. (biosciregister.com)
  • Further experiments designed to elucidate the target involved in CXCL14 function revealed that CXCL14 is neither an agonist nor an antagonist for the CXCR7 receptor and the putative CXCR4 receptor, and thus these receptors are not responsible for mediating CXCL14 function. (bl.uk)
  • These vGPCRs show highest homology to human chemokine receptors, which play a key role in the immune system. (nih.gov)
  • We used the inositol 1,4,5-trisphosphate (IP 3 ) biosensor, the pleckstrin homology (PH) domain of PLCδ1 (phospholipase C) tagged with enhanced green fluorescent protein (eGFP-PH PLCδ ), to examine muscarinic acetylcholine (mACh) receptor regulation of phospholipase C/IP 3 signaling in intact single hippocampal neurons in "real time. (jneurosci.org)
  • and atypical 7 TM proteins ( Fig. 1 D). This classification is based on primary and secondary structure predictions, sequence analysis using profile hidden Markov models, and sequence homology searches using BLAST. (rupress.org)
  • The present invention is directed to a constitutively active G protein coupled receptor of human herpesvirus 8, as well as a method of identifying negative antagonists of a constitutively active G protein coupled receptor. (nih.gov)
  • and determining a level of reporter protein activity, wherein the level of reporter protein activity indicates effectiveness of the test substance as a negative antagonist of the constitutively active G protein coupled receptor. (nih.gov)
  • The invention further provides a method of preventing tumor formation or cell proliferation caused by a constitutively active G protein coupled receptor. (nih.gov)
  • Removal of these interactions is expected to generate constitutively active receptors. (uni-wuerzburg.de)
  • In contrast, p23 overexpression suppressed temperature sensitivity and AhR signaling defects in the hsp82G170D mutant strain, suggesting that there is a relationship between these 2 proteins. (bioone.org)
  • Overexpression of nuclear receptor binding SET domain protein 2 (NSD2) is frequent in multiple myeloma (MM). However, existing NSD2 inhibitors are largely ineffective in suppressing MM cell proliferation. (genscript.com)
  • Yet, even augmenting the sensitivity to detect constitutive activity (CA) with overexpression of the receptor or the G protein revealed resistance to an increase in basal activity, while retaining fully the ability to cause agonist-induced signaling. (uni-wuerzburg.de)
  • The functional significance of this topological regulation is illustrated by the CCR5 chemokine receptor. (elifesciences.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • All invasive breast cancers are tested for the HER2 protein to see if too much is being made. (cancer.org)
  • Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. (joplink.net)
  • Proton nuclear magnetic resonance studies on cyclic nucleotide binding to the Escherichia coli adenosine cyclic 3',5'-phosphate receptor protein. (nih.gov)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Specifically, the cancer is tested for estrogen receptor (ER) and progesterone receptor (PR). (cancer.org)
  • The apparent M(r) of this sialoglycoprotein is 63,000, and this protein does not contain disulfide-linked subunits or O-linked carbohydrates. (nih.gov)
  • Additionally, in the brain AMPARs associate with auxiliary subunits, which modify the properties of the receptors. (frontiersin.org)
  • The light photons cause the activated form of rhodopsin to bind to its protein partner, transducin, made up of three subunits (green, yellow, and purple). (nih.gov)
  • The mitochondrial ribosomes (mitoribosomes) synthesize, almost exclusively, membrane proteins that are subunits of oxidative phosphorylation complexes. (molbiolcell.org)
  • The ADGRE2 protein consists of two parts (subunits) that interact with each other: an alpha subunit that lies on the outside surface of the cell and a beta subunit that crosses the cell membrane and extends into the cell. (medlineplus.gov)
  • The substitution alters the protein structure and leads to a less stable interaction between the two subunits. (medlineplus.gov)
  • To investigate M 1 mACh receptor regulation, neurons were stimulated with approximate EC 50 concentrations of the mACh receptor agonist methacholine before (R1) and after (R2) a short (60 sec) exposure to a high concentration of agonist. (jneurosci.org)
  • Manipulation of endogenous GRK2 activity through introduction of either wild-type or catalytically inactive GRK2 ( K220R GRK2) almost completely inhibited agonist-stimulated IP 3 production, implying a phosphorylation-independent regulation of M 1 mACh receptor signaling, most probably mediated by a GRK2 N-terminal RGS-like (regulator of G-protein signaling) domain interaction with GTP-bound Gα q/11 . (jneurosci.org)
  • These results suggest the existence of additional constrains governing the shift of TP receptor to its active state, together with an increase propensity of these mutants to agonist-induced signaling, corroborating their definition as superactive mutants. (uni-wuerzburg.de)
  • In this study, electron microscopic examination and expression of TGF-beta-1 protein and TGF-beta-R-1 receptor using immunoelectronmicroscopic and immunocytochemical techniques were investigated in urine and peripheral blood mononuclear cells (PBMNCs). (medscape.com)
  • H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness. (nih.gov)
  • Severe childhood malaria is associated with expression of specific PfEMP1 subtypes containing domain cassettes (DCs) 8 and 13 (ref. 3 ), but the endothelial receptor for parasites expressing these proteins was unknown 4 , 5 . (nature.com)
  • Firstly, we confirmed that CPT1C is an interacting protein of AMPARs in heterologous expression systems. (frontiersin.org)
  • 2002 ) have reported that CB 1 cannabinoid receptor desensitization can be attenuated by the expression of a dominant-negative GRK2 mutant in rat hippocampal neurons. (jneurosci.org)
  • TLR2, TLR4 and TLR5 protein expression was quantified by immunohistochemistry. (bmj.com)
  • Conclusions Persistently positive TLR expression and lower expression of TLR inhibitors was associated with higher TLR protein levels throughout the spectrum of lesions of colon carcinogenesis. (bmj.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
  • Data collected by these projects will enhance the overall goals of the IDG program by demonstrating the quality and utility of IDG data and reagents to the scientific community, increasing awareness of the IDG program, and/or extending the characterization of IDG-eligible proteins. (nih.gov)
  • Estrogen receptor accessory proteins: effects on receptor-DNA interactions. (nih.gov)
  • Amongst iGluRs, the AMPA receptors (AMPARs) are essential as they mediate 90% of the fast excitatory neurotransmission in the central nervous system (CNS). (frontiersin.org)
  • As receptors they mediate many critical cell-cell interactions. (europa.eu)
  • However, our understanding of how APP and its proteolytic products contribute to degeneration remains incomplete, which has led to efforts to identify APP-interacting proteins that mediate neurodegeneration. (jneurosci.org)
  • Fukudome, K. & Esmon, C. T. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. (nature.com)
  • Despite the abundance of AMPAR partners, recent proteomic studies have revealed even more interacting proteins that could potentially be involved in AMPAR regulation. (frontiersin.org)
  • Together, our data suggest a role for both phosphorylation-dependent and -independent regulation of M 1 mACh receptors in hippocampal neurons. (jneurosci.org)
  • Our data reveal a potential role for both phosphorylation-dependent and -independent regulation of mACh receptor signaling on the basis of manipulations of GRK2 and GRK6 activities through the introduction of wild-type or dominant-negative GRK mutants. (jneurosci.org)
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
  • The GPCRdb browsing system is structured on most relevant categories which are: GPCRdb Receptors G Proteins B-Arrestins Biased Signaling Ligands Drugs Structure Constructs Tutorials, workshops and documentation of use. (wikipedia.org)
  • The encoded protein can also modulate signaling of other melanocortin receptors. (nih.gov)
  • This allows vGPCRs to hijack human proteins and modulate cellular signaling for the benefit of the virus, ultimately resulting in immune evasion and viral dissemination to establish a widespread and lifelong infection. (nih.gov)
  • The mutated hsp82G170D protein lacked detectable ATPase activity and p23 binding in vitro , which may relate to the weakened AhR signaling observed in mutant cells. (bioone.org)
  • These studies implicate the p23 protein and the G170 region of Hsp90 as being important, but not essential, for AhR signaling. (bioone.org)
  • Marc B. Cox and Charles A. Miller "Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling," Cell Stress & Chaperones 9(1), 4-20, (1 March 2004). (bioone.org)
  • Receptor phosphorylation may attenuate signaling per se and/or may facilitate recruitment of arrestin proteins ( Krupnick and Benovic, 1998 ). (jneurosci.org)
  • The phosphorylated receptor-arrestin complex can be internalized and may also act as an adaptor scaffold to recruit other signaling pathways ( Ferguson, 2001 ). (jneurosci.org)
  • This PfEMP1 adhesive property links P. falciparum cytoadhesion to a host receptor involved in anticoagulation and endothelial cytoprotective pathways, and has implications for understanding malaria pathology and the development of new malaria interventions. (nature.com)
  • This amino acid activates primarily ionotropic glutamate receptors (iGluRs): NMDA, AMPA, and Kainate receptors. (frontiersin.org)
  • Receptor for glutamate. (hmdb.ca)
  • Instead, when acetylcholine attaches to the external part of the muscarinic receptor, the internal portion of the receptor releases large guanine nucleotide binding proteins (G-Proteins) (See note below), inside the cell. (cdc.gov)
  • Sequestration is mediated by specific interactions between members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family and receptors on the endothelial lining 2 . (nature.com)
  • IRAK1BP1 has direct interactions with proteins and molecules. (creativebiomart.net)
  • Awards will support the generation of additional data and tools around understudied protein(s) identified by the IDG Program to elucidate the function of these proteins in the context of human disease. (nih.gov)
  • The G protein-coupled receptor repertoires of human and mouse. (nih.gov)
  • 1/2 log 10 increased infectivity in human cells expressing the human ACE2 protein as the viral receptor. (biorxiv.org)
  • AhR interacts with heat shock protein (Hsp) 90 complexes and can be used as a functional substrate to detect chaperone-dependent processes. (bioone.org)
  • Our results are consistent with a model in which p23 inhibits Hsp90 ATPase activity, thereby stabilizing ATP-Hsp90-client protein complexes. (bioone.org)
  • Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. (harvard.edu)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • It mediates infection of target cells through binding to its cognate receptor angiotensin converting enzyme 2 (ACE2) and then initiating viral-host cell membrane fusion ( 4 ). (biorxiv.org)
  • However, direct G protein activation measured through bioluminescence resonance energy transfer (BRET) indicates that these mutants more efficiently communicate and/or activate their cognate G proteins. (uni-wuerzburg.de)
  • Experiments in animal models of tau and αS pathology have demonstrated that the passive transfer of anti-tau or anti-αS antibodies induces a reduction in the levels of assembled proteins. (frontiersin.org)
  • However, there are several remaining uncertainties concerning the mechanism by which antibodies afford protection against self-propagating protein conformations. (frontiersin.org)
  • This review will discuss current understanding of how antibodies and their receptors can be brought to bear on proteins involved in neurodegeneration. (frontiersin.org)
  • Abnova Corporation is engaged in the production of antibodies and proteins. (biosciregister.com)
  • Monoclonal antibodies that bind the programmed cell death-1 protein (PD-1) ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell proliferation and cytokine production. (medscape.com)
  • EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)
  • The increased binding/fusion activity of the D614G Spike protein was corroborated in a cell fusion assay using Spike and ACE2 proteins expressed in different cells. (biorxiv.org)
  • Missense mutations in the melanocortin 2 receptor accessory protein that lead to late onset familial glucocorticoid deficiency type 2. (nih.gov)
  • also known as the thymic stromal lymphopoietin receptor), which together with IL7 receptor alpha forms a heterodimeric complex that acts at the functional receptor for thymic stromal lymphopoietin (reviewed in Roll and Reuther, 2010). (atlasgeneticsoncology.org)
  • Heat shock proteins regulating Toll-like receptors and the immune system could be a novel therapeutic target for melanoma. (physiciansweekly.com)
  • TLRs are innate immune system receptors, involved in the melanoma growth pathway through HSP activation. (physiciansweekly.com)
  • The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. (nih.gov)
  • The specfic function of the P2RY8 receptor remains uncharacterised. (atlasgeneticsoncology.org)
  • Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
  • Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A(2). (creativebiomart.net)
  • Recent studies implicate death receptor 6 (DR6) in an amyloid precursor protein (APP)-dependent pathway regulating developmental axon pruning, and in a pruning pathway operating during plastic rearrangements in adult brain. (jneurosci.org)
  • Outcomes such as generated tools and data collection by these projects will enhance the overall goals of the IDG Program by expanding the resources available for the scientific community, increasing awareness of the IDG Program through use of IDG-generated resources, and/or extending the characterization of IDG-eligible proteins. (nih.gov)
  • Alzheimer's disease (AD) is the most common of a heterogeneous family of age-related neurodegenerative disorders characterized by the deposition of specific protein assemblies in the brain. (frontiersin.org)
  • suggesting the intriguing possibility that APP may itself be a receptor for Wnt family member. (elifesciences.org)
  • They are single-chain molecules present on host cellular membranes and belong to the complement control protein family. (medscape.com)
  • We show that EPCR binding is mediated through the amino-terminal cysteine-rich interdomain region (CIDRα1) of DC8 and group A PfEMP1 subfamilies, and that CIDRα1 interferes with protein C binding to EPCR. (nature.com)
  • The transcribed RNA has 4198 base-pairs and encodes a 359 amino acid protein. (atlasgeneticsoncology.org)
  • Most prominent among these is the D614G amino acid substitution in the SARS-CoV2 Spike protein, which mediates viral entry. (biorxiv.org)
  • RNA Codewords and Protein Synthesis, II. (nih.gov)
  • Mrx15 contacts mitochondrial translation products during their synthesis and plays, together with the ribosome receptor Mba1, an overlapping role in cotranslational protein insertion. (molbiolcell.org)
  • 806-PE38 reduced the viability of multiple TNBC lines through inhibition of protein synthesis in a concentration-dependent manner, while not affecting cells with wild-type EGFR. (nih.gov)
  • Paclitaxel protein bound is a microtubular inhibitor (albumin-conjugated formulation) and a natural taxane that prevents depolymerization of cellular microtubules, which results in DNA, RNA, and protein synthesis inhibition. (medscape.com)
  • Ifosfamide inhibits DNA and protein synthesis and, thus, cell proliferation, by causing DNA cross-linking and denaturation of double helix. (medscape.com)
  • CD71 Antibody is designed for the detection of Cluster of differentiation 71 (CD71), also known as Transferrin Receptor Protein 1 (TfR1). (neuromics.com)
  • The Spike glycoprotein is a type I membrane protein and the largest surface protein of the SARS-CoV2 coronavirus. (biorxiv.org)
  • Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
  • CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)