• The N-terminal SH3 domain binds to proline-rich peptides and can bind to the Ras-guanine exchange factor SOS. (wikipedia.org)
  • A vast amount of research has focused on understanding the molecular mechanisms that underlie the ability of these receptors to mediate diverse cellular functions. (asm.org)
  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. (wikipedia.org)
  • PAF also induces apoptosis in a different way that is independent of the PAF receptor. (wikipedia.org)
  • Hypoxia also causes the upregulation of hypoxia-inducible factor 1 alpha (HIF1-α), which induces angiogenesis and is associated with poorer prognosis and the activation of genes associated with metastasis, leading, for instance, to increased cell migration and also ECM remodeling. (wikipedia.org)
  • FIP1L1 is a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex that polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). (wikipedia.org)
  • Results from recently published studies have shown that the addition of antivascular endothelial growth factor (VEGF) treatment to first-line chemotherapy may be beneficial for a fraction of ovarian cancer patients [ 3 , 4 ], also in the treatment of the recurrent disease [ 5 - 7 ]. (hindawi.com)
  • The concept of combining antivascular compounds or angiogenesis inhibitors has been extensively investigated for the combination of vascular endothelial growth factor (VEGF) signaling inhibitors concurrently or sequentially together with radiotherapy ( 6 - 15 ). (aacrjournals.org)
  • The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (wikipedia.org)
  • The tumor microenvironment (TME) is the cellular environment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix (ECM). (wikipedia.org)
  • Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (wikipedia.org)
  • He investigated the role of growth factor-regulated cyclin-dependent kinase (CDK) activity in the control of cellular proliferation, and used mouse models to explore the role of CDK activity in tumor formation. (wikipedia.org)
  • Objective- Myocardin, a potent transcriptional coactivator of serum response factor, is involved in vascular development and promotes a contractile smooth muscle phenotype. (ahajournals.org)