• Given that human trust behavior is heritable and intranasal administration of oxytocin enhances trust, the oxytocin receptor (OXTR) gene is an excellent candidate to investigate genetic contributions to individual variations in trust behavior. (frontiersin.org)
  • This biological effect of OXT operates through its cognate receptor, the OXT receptor (OXTR). (frontiersin.org)
  • On www.antibodies-online.com are 29 Oxytocin Receptor (OXTR) ELISA Kits from 8 different suppliers available. (antibodies-online.com)
  • Genetic variation in OXTR and GRK6 (show GRK6 ELISA Kits ) is associated with the amount of oxytocin required as well as the duration of labor and risk for cesarean delivery among women undergoing induction of labor near term. (antibodies-online.com)
  • Illumina HM450 microarray data generated in a prospective PPD (show HPD ELISA Kits ) cohort identified significant associations (P = 0.014) with PPD (show HPD ELISA Kits ) in an intronic region in the OXTR located 4 bp proximal to an estrogen receptor (ER (show ESR1 ELISA Kits )) binding region. (antibodies-online.com)
  • Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific. (frontiersin.org)
  • The human oxytocin receptor gene (OXTR) represents a plausible candidate gene for the etiology of ASD. (nih.gov)
  • Genes in the oxytocin pathway, which mediates social behaviours in humans, have been studied with single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) being implicated in ASD. (queensu.ca)
  • Therefore, the aim of this study is to examine whether a plausible candidate gene (the oxytocin receptor gene, OXTR) is associated with gazing behavior. (scirp.org)
  • While abuse associates with methylation of certain genes, particularly those in the stress response system, no study to date has evaluated abuse and methylation of the oxytocin receptor (OXTR). (dspacedirect.org)
  • The oxytocin receptor gene (OXTR) has been associated with differences in social brain function and risk for autism. (scirp.org)
  • Oxytocin receptor gene polymorphism modulates effects of social support in the context of stress. (antibodies-online.com)
  • several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. (nih.gov)
  • Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (-212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5' and 3' UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. (nih.gov)
  • The gene-behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. (nih.gov)
  • Bale, TL & Dorsa, DM 1998, ' Transcriptional regulation of the oxytocin receptor gene ', Advances in experimental medicine and biology , vol. 449, pp. 307-315. (elsevier.com)
  • The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. (abnova.com)
  • Our main investigation is to show that the emotional state of moral elevation is linked to epigenetic and genetic profiles of the oxytocin receptor gene, autonomic physiology, psychological profiles, behavioral displays, and oxytocin release. (up.edu)
  • Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits. (nih.gov)
  • Roper, J, Craighead, M, O'Carroll, A-M & Lolait, S, 2010, Attenuated stress response to acute restraint and forced swimming stress in vasopressin Avpr1b receptor knockout mice and wild type mice treated with a novel Avpr1b receptor antagonist . (bristol.ac.uk)
  • Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. (rndsystems.com)
  • Oxytocin Receptor Antagonists " has 3 results in Products. (rndsystems.com)
  • The pharmacology of AMPA receptors and their antagonists. (rndsystems.com)
  • Oxytocin and opioid receptor genes are among the candidates for nervous system pathways that regulate canine social behavior toward humans. (frontiersin.org)
  • First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. (nih.gov)
  • Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system. (nih.gov)
  • Evidence supports the involvement of oxytocin in social behavior. (scirp.org)
  • A. H. Kemp and A. J. Guastella, "Oxytocin: Prosocial Behavior, Social Salience, or Approach-Related Behavior? (scirp.org)
  • Our data lends credence to the claim that this genetic variation of oxytocin influences emotional processing and other-oriented behavior," she said. (healthy.net)
  • Oxytocin: How Does This Neuropeptide Change Our Social Behavior? (frontiersin.org)
  • I am especially interested in how both the oxytocin and cardiovascular systems influence our social behavior and perceptions. (frontiersin.org)
  • When given to people in the form of a nasal spray, oxytocin can change key aspects of social behavior, such as how easily we can recognize emotions in others. (frontiersin.org)
  • For example, during childbirth, the body releases a huge amount of oxytocin, which activates oxytocin receptors located on the mother's uterus (an organ located in the abdomen where the baby develops before birth). (frontiersin.org)
  • Key receptors being studied are the vasopressin V1b receptor, the oxytocin receptor, the apelin receptor and the recently characterised G protein-coupled oestrogen receptor (GPER), as well as a number or 'orphan' G protein-coupled receptors. (bristol.ac.uk)
  • R. Landgraf and I. D. Neumann, "Vasopressin and Oxytocin Release within the Brain: A Dynamic Concept of Multiple and Variable Modes of Neuropeptide Communication," Frontiers in Neuroendocrinology, Vol. 25, No. 3-4, 2004, pp. 150-176. (scirp.org)
  • Vasopressin/oxytocin receptor subfamily. (abcam.cn)
  • In line with its prosocial effects in animals, oxytocin has been shown to enhance trust [4] and generosity in humans [5]. (scirp.org)
  • Investigations using functional magnetic resonance imaging (fMRI) provide further evidence that oxytocin modulates social approach by regulating neural adaptations to social fear. (scirp.org)
  • One of the most established roles of oxytocin (OT) is in inducing uterine contractions and labour. (aspetjournals.org)
  • I have focused on the study of the neurohypophyseal hormone oxytocin and inflammatory lipid mediators including prostaglandins in the control of uterine activity. (bristol.ac.uk)
  • Oxytocin is an evolutionarily highly conserved neuropeptide that plays an important role in various complex social behaviors, such as social cognition, trust, attachment, and sociability ( Donaldson and Young, 2008 ). (frontiersin.org)
  • Oxytocin is a neuropeptide that plays a crucial role in childbirth and breastfeeding. (frontiersin.org)
  • Eye-tracking data also indicates that oxytocin increases gaze to eye regions [19]. (scirp.org)
  • Additionally we are shipping Oxytocin Receptor Antibodies (108) and Oxytocin Receptor Proteins (8) and many more products for this protein. (antibodies-online.com)
  • Additionally we are shipping beta 2 Adrenergic Receptor Antibodies (280) and beta 2 Adrenergic Receptor Proteins (4) and many more products for this protein. (antibodies-online.com)
  • The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. (abcam.cn)
  • In addition to these species differences in receptor distribution, testosterone had effects in the mouse which differed from the induction of receptors previously reported in the rat. (nih.gov)
  • We did not identify significant differences in the prevalence of oxytocin receptor variants between low-dose-requiring and high-dose-requiring women, but novel oxytocin receptor variants were enriched in the high-dose-requiring women. (antibodies-online.com)
  • The aim of the present study was to investigate the topographical differences in functional contractile PG and oxytocin receptors in mid-cycle isolated myometrium. (endocrine-abstracts.org)
  • Differences in oxytocin receptor (OTR) and OTR mRNA between caruncular. (ku.dk)
  • Regional expression of oxytocin has been found to explain differences in sociality within and between species [2]. (scirp.org)
  • Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains. (nih.gov)
  • Our data indicate that, depending on their localization, oxytocin receptors transactivate EGFR and activate ERK1/2 using different signalling intermediates. (nih.gov)
  • Increase of cytoplasmatic oxytocin receptor localization and correspondent decrease in nuclear oxytocin receptor correlates with increased concentration of oxytocin, as described in literature. (abcam.cn)
  • In the first study of its kind, a variation in the hormone/neurotransmitter oxytocin's receptor was linked to a person's ability to infer the mental state of others. (healthy.net)
  • One specific aim will center on how moral elevation, an emotional state generated through witnessing great acts of compassion, is related to caregiving behaviors and variations in the oxytocin system, a hormone important for an array of prosocial behaviors, including social bonding. (up.edu)
  • Celebrations are characterized by rhythmic music, and studies show that oxytocin (social bonding hormone) is released not only when people sing together (Grape, et al, 2003), but during ritual performance (Levitin, 2008). (hubpages.com)
  • Apart from contractions, our recent study have shown that OT can also activate pro-inflammatory pathways in both human myometrial and amnion cells which suggests the pro-inflammatory role of OT should be taken into account when developing tocolytics targeting the OT/OT receptor (OT/OTR) system. (aspetjournals.org)
  • Dysfunctional prostanoid and oxytocin receptors have been implicated in the development of myometrial hyperactivity, causing dysmenorrhoea and infertility. (endocrine-abstracts.org)
  • Contractile receptor dynamics and mechanotransduction pathways are currently being investigated further to improve the development of treatments for aberrant myometrial function. (endocrine-abstracts.org)
  • On www.antibodies-online.com are 46 Adrenergic, beta-2-, Receptor, Surface (ADRB2) ELISA Kits from 13 different suppliers available. (antibodies-online.com)
  • Finally, only the activation of receptors located outside caveolar microdomains correlates with the activation of the cell cycle inhibitor p21(WAF1/CIP1), thus suggesting that the antiproliferative OTR effects may, in this case, be achieved by a sustained activation of EGFR and MAPK leading to the induction of this cell cycle regulator. (nih.gov)
  • Overlaying the genetics are studies that have sought to understand the role of neuropeptides in the brain such as oxytocin (OXT). (frontiersin.org)
  • Our group works on investigating the molecular genetics of neuropeptide receptors, with particular reference to the molecular basis of the structural and functional diversity of receptors in the hypothalamo-pituitary-adrenal (HPA) axis and hypothalamo-neurohyphysial system (HNS), and peripheral tissues such as the kidney, pancreas, mammary gland, uterus and ovary. (bristol.ac.uk)
  • Rodrigues said previous research has shown that people with autism display lower scores on behavioral and dispositional empathy measures, and that a nasal spray with oxytocin increases scores in these areas. (healthy.net)
  • People with autism often have difficulties in understanding and using social information, and scientists have been testing oxytocin nasal spray as a potential treatment. (frontiersin.org)
  • But how does oxytocin nasal spray travel from the nose to the brain, and how does it change how we behave socially? (frontiersin.org)
  • Artificial oxytocin nasal spray is thought to access the brain directly through the nerves located inside the nasal cavity that are linked to the brain. (frontiersin.org)
  • Artificial oxytocin nasal spray has been shown to affect activity in different parts of the brain, such as the prefrontal cortex, amygdala, and the brain stem. (frontiersin.org)
  • Small amounts of the oxytocin nasal spray are sometimes swallowed, which is relatively harmless. (frontiersin.org)
  • If mothers are having difficulty in delivering the baby or with breastfeeding, their doctors will sometimes prescribe oxytocin (an artificial version that is sometimes delivered via a nasal spray) to help them with these processes. (frontiersin.org)
  • According to primate studies, endogenous opioid peptide (e.g., endorphins) receptor genes have also been implicated in social relationships. (frontiersin.org)
  • S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT- LTP (show SCP2 ELISA Kits )), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C ELISA Kits ) and enhancement of its activity by the beta2-adrenergic receptor ( beta2AR )-cAMP-PKA cascade. (antibodies-online.com)
  • knocking out of the beta1/2 (show TFAP2B ELISA Kits ) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. (antibodies-online.com)
  • The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. (abnova.com)
  • These receptors signal contraction of the uterus, which assists the baby's trip through the birth canal during birth. (frontiersin.org)
  • A social approach behaviour for which the effects of oxytocin have been intensively studied is emotion recognition of facial expressions. (scirp.org)
  • Systematically infused oxytocin has been shown to improve the accuracy of emotion recognition [9-11]. (scirp.org)
  • Moreover, studies report that oxytocin alleviates emotion recognition deficits among persons with autism spectrum conditions (ASC) [12,13], generating much clinical interest in the neuropeptide [14]. (scirp.org)
  • An emerging account suggests that oxytocin enhances emotion recognition by altering emotional evaluations of facial expressions. (scirp.org)
  • Evidence that oxytocin-enhanced emotion recognition is strongest for threatening expressions support this view [22,23]. (scirp.org)
  • Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release. (rndsystems.com)
  • Hence, accumulating evidence suggests that oxytocin enhances the perception of non-verbal social information such as facial expressions. (scirp.org)
  • The final outcome is a different temporal pattern of EGFR and ERK1/2 phosphorylation, which is more persistent when the receptors are located outside caveolar microdomains and inhibit cell growth, and very transient when they are located in caveolar microdomains and stimulate cell growth. (nih.gov)
  • It is suspected that positive effects seen in Transcranial Magnetic Therapy used to treat depression may be operating on this mechanism, acting on natural receptors in the limbic system which also capture light and are implicated in mood transitions. (scirp.org)
  • We have recently shown that oxytocin inhibits cell proliferation when the vast majority of oxytocin receptors are excluded from caveolin-1-enriched microdomains, and that, on the contrary, it has a mitogenic effect when the receptors are targeted to these plasma membrane domains. (nih.gov)
  • Individuals can have one of three combinations of this particular naturally occurring genetic variation of the oxytocin receptor. (healthy.net)
  • Gonadal steroids have paradoxical effects on brain oxytocin receptors. (nih.gov)
  • Specific brain receptors for oxytocin have been described in several mammalian species. (nih.gov)
  • The distribution of these receptors differs greatly across species and in the rat, receptor binding in specific brain regions appears to depend upon gonadal steroids. (nih.gov)
  • In other regions of the mouse brain, such as the intermediate zone of the lateral septum, binding to oxytocin receptors was increased with testosterone treatment. (nih.gov)
  • These results suggest that the brain oxytocin receptor varies across species not only in its distribution but also in its regional regulation by gonadal steroids. (nih.gov)
  • These apparently paradoxical changes in oxytocin receptor binding may result from either direct or indirect effects of gonadal steroids in mouse brain. (nih.gov)
  • The blood-brain barrier acts like a protective filter for the brain by preventing unwanted molecules entering the brain from the blood stream, but it can also prevent the entrance of large drug molecules, such as oxytocin. (frontiersin.org)
  • Later on, when a baby breastfeeds, oxytocin is released from the mother's brain to stimulate the flow of breast milk. (frontiersin.org)
  • Rodrigues said oxytocin has already been significantly linked with social affiliation and reduction in stress. (healthy.net)
  • This study used in vitro receptor autoradiography to examine the effects of testosterone on oxytocin receptor binding in the mouse forebrain. (nih.gov)
  • In this study, we investigated whether the receptors located inside and outside caveolar microdomains initiate different signalling pathways and how this may lead to opposite effects on cell proliferation. (nih.gov)
  • Furthermore, animal studies showed anxiety and stress-reduced effects of oxytocin. (nih.gov)
  • To investigate the effects of P4 on oxytocin (OT) signaling, cells were transiently transfected with the ovine OTR. (elsevier.com)
  • Evidence has gathered to suggest that oxytocin exerts its prosocial effects by regulating the aversiveness of social experiences, such as reducing the impact of betrayal on trust behaviour [4,6]. (scirp.org)
  • A recent important study shows that oxytocin also produces non-prosocial effects, such as increased gloating and envy [7]. (scirp.org)
  • Reduced responding in neural bases of social fear such as the amygdala is shown to be concurrent with oxytocin-induced increases in prosocial behaviour [24]. (scirp.org)
  • We confirmed that the OT receptor and insulin receptor mRNAs are expressed in 3T3L1 adipocytes by real-time PCR analysis. (scirp.org)
  • The neurotransmitter crosses the synapse and binds to a specialized site, called a receptor, on the other side. (frontiersin.org)
  • Each neurotransmitter binds only to its specific receptor, just as a key fits only in a particular lock. (frontiersin.org)
  • Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro . (rndsystems.com)
  • Initial evidence for this role came from animal research reports that oxytocin promotes maternal bonding [1], mate affiliation and social recognition [2]. (scirp.org)
  • Based on this evidence, the effect of oxytocin has been reinterpreted as the enhanced motivation for all types of social approach behaviours by inhibiting fear responses to social stimuli [8]. (scirp.org)
  • Evidence indicates that oxytocin reduces the aversiveness of faces [17,18]. (scirp.org)
  • The present study was conducted to determine if progesterone (P4) would inhibit oxytocin-stimulated phosphoinositide hydrolysis in COS-7 cells expressing transfected ovine oxytocin receptor (OTR) with little or no nuclear P4 receptor (nPR) protein present. (elsevier.com)
  • An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. (nih.gov)
  • Thus, the oxytocin system might be involved in the impairment of social interaction and attachment in autism spectrum disorders (ASD). (nih.gov)
  • This thesis examines the presence of different oxytocin receptor genotypes, and their associations with ASD and resulting social communication deficits. (queensu.ca)
  • T. Insel and L. Shapiro, "Oxytocin Receptor Distribution Reflects Social Organization in Monogamous and Polygamous Voles," Proceedings of the National Academy of Sciences USA, Vol. 89, No. 13, 1992, pp. 5981-5985. (scirp.org)
  • The abundant neuropeptide oxytocin is an essential regulator of social behaviour. (scirp.org)
  • Hence, oxytocin may facilitate social communication by overcoming avoidance reactions and enabling increased depth of processing of facial affect. (scirp.org)
  • These data support a role for a non-genomic action for P4 in OTR signaling via some mechanism other than by binding to a membrane progestin receptor in an immortalized, transfected cell. (elsevier.com)
  • IgE binds to the high affinity receptor FcεRI on the surface of basophils, mast cells, and other cell types, such as neutrophils, eosinophils, monocytes dendritic cells and platelets [10]. (scirp.org)
  • Irrespective of steroid treatment, the distribution of oxytocin receptors in mouse forebrain differed markedly from patterns previously described in the rat. (nih.gov)