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Oncostatin MLeukemia Inhibitory FactorReceptors, Oncostatin MGrowth InhibitorsOncostatin M Receptor beta SubunitCytokine Receptor gp130Receptors, CytokineInterleukin-6LymphokinesSTAT3 Transcription FactorCiliary Neurotrophic FactorPeptidesSulfhemoglobinInterleukin-11Receptors, Interleukin-6SulfhemoglobinemiaCells, CulturedLeukocyte Migration-Inhibitory FactorsSignal TransductionEmbryo ImplantationCytokinesRNA, MessengerCell DifferentiationJanus Kinase 1STAT Transcription FactorsAntigens, CDMembrane GlycoproteinsEmbryonic Stem CellsGene Expression RegulationTrans-ActivatorsDNA-Binding ProteinsInterleukin-1Suppressor of Cytokine Signaling ProteinsCell DivisionCell LineEndometriumPotassium CompoundsMice, Inbred C57BLThermoluminescent DosimetryStem CellsSTAT1 Transcription FactorReverse Transcriptase Polymerase Chain ReactionCulture Media, ConditionedSTAT5 Transcription FactorRecombinant ProteinsJanus KinasesMolecular Sequence DataMatrix Metalloproteinase 13Osmolar ConcentrationJanus Kinase 2Receptor, Ciliary Neurotrophic FactorBase SequenceOsmotic PressurePluripotent Stem CellsKidney Concentrating AbilityPhosphorylationTumor Cells, CulturedProtein-Tyrosine KinasesMice, KnockoutUterusDrug SynergismMilk ProteinsBlotting, WesternAcute-Phase ProteinsCell ProliferationGene ExpressionImmunohistochemistryBlastocystContactinsTissue Inhibitor of Metalloproteinase-3DiuresisCiliary Neurotrophic Factor Receptor alpha SubunitUp-RegulationReceptors, InterleukinEmbryo, MammalianCattleTransfectionChondrocytesTissue Inhibitor of Metalloproteinase-1Amino Acid SequenceDNA LigasesMitogen-Activated Protein KinasesBlotting, NorthernInflammation MediatorsCartilage, ArticularPregnancyCloning, MolecularTissue Culture TechniquesFibroblastsDose-Response Relationship, DrugSorbitolCartilageDesiccationElectrophoresis, CapillaryProtein BindingReceptors, Interleukin-11HydroxidesEmbryo Implantation, DelayedEnzyme InhibitorsProteins
CNTFCytokinesInterleukinOncostatinChemokine receptorSubunitSpecificityLIFRComplexesLeukemiaPathwayProteinSolubleOSMRAntibodyPattern recognitResiduesHomologyBindsSignalsImmunologyIFNAR1GenesSTAT3InhibitorEndothelialMonocytesMediatorsIntracellularSignalSequenceMolecularMicePathwaysColonySimilaritiesGeneComplexHelixCellTypeHumanFunctionSites
CNTF6
Cytokines11
  • OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. (wikipedia.org)
  • Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. (wikipedia.org)
  • Like many cytokines OSM is produced from cells by de novo synthesis followed by release through the classical secretion pathway. (wikipedia.org)
  • Primary sequence analysis of OSM allocates it to the gp130 group of cytokines. (wikipedia.org)
  • Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF (RMSD of 2.1 Å across 145 equivalent Cα). (wikipedia.org)
  • The neuroinflammatory response was further confirmed with elevated pSTAT3 protein by ELISA and elevated neuroinflammatory cytokines and chemokines mRNA (TNFalpha, IL6, CCL2, IL1beta, LIF, and OSM) by qPCR. (cdc.gov)
  • They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. (antibodies-online.cn)
  • In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)
  • All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. (dimabio.com)
  • The activation of this protein is dependent upon the binding of cytokines to their receptors. (betalifesci.com)
  • Upon binding to their receptors, cytokines activate JAKs which then phosphorylate the cytokine receptor, thereby creating docking sites for signaling molecules, notably, members of the signal transducer and activator of transcription (STAT) family that ultimately lead to gene expression. (justia.com)
Interleukin3
  • The thesis also contains an exploratory study of interactions between interleukin-2 (IL-2) and the IL-2 receptor β chain. (bl.uk)
  • Below are the most recent publications written about "Receptors, Interleukin" by people in Profiles over the past ten years. (uams.edu)
  • Leukemia inhibitory element (LIF), an interleukin (IL) 6-type cytokine, is among the few substances obligatory for fertility in mice [8]. (cancerhugs.com)
Oncostatin7
  • Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. (wikipedia.org)
  • These two receptor complexes, namely gp130/LIFR and gp130/OSMR, were termed the type I and type II Oncostatin-M receptors. (wikipedia.org)
  • This thesis describes the characterization of the interactions between the cytokine oncostatin M (OSM) and the cytokine-binding homology region (CHR) of its receptor gp130. (bl.uk)
  • STAT3C also led to the up-regulation of the oncostatin M (OSM) and LIF receptors. (ox.ac.uk)
  • The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation. (mpi-hlr.de)
  • The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice. (mpi-hlr.de)
  • Sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved surface character. (ox.ac.uk)
Chemokine receptor3
  • PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
  • Exploring the Role of Chemokine Receptor 6 ( Ccr6 ) in the BXD Mouse Model of Gulf War Illness. (cdc.gov)
  • Chemokine receptor 6 (CCR6) has been shown to be involved in several inflammation disorders in humans. (cdc.gov)
Subunit1
  • The S1 subunit contains a receptor binding domain or RBD that binds with the specific receptors, while the S2 subunit helps membrane fusion. (openaccesspub.org)
Specificity1
  • Analysis of the biological function and receptor specificity of a series of human-mouse LIF chimeras implicate two regions of receptor interaction that are located in the fourth helix and the preceding loop. (ox.ac.uk)
LIFR5
  • The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. (wikipedia.org)
  • Subsequently it was shown that the presence of gp130 alone was sufficient to reproduce the low affinity form of the receptor, and co-transfection of COS-7 cells with LIFR and gp130 produced a high affinity receptor. (wikipedia.org)
  • Through studying a series of 19 families with SWS/SJS2, we have mapped the disease gene to chromosome 5p13.1 at locus D5S418 (Z max = 10.66 at θ = 0) and have identified null mutations in the leukemia inhibitory factor receptor (LIFR or gp190 chain) gene. (tau.ac.il)
  • A late-stage bone marrow DC progenitor expressed low amounts of LIFR and developed into pDCs less efficiently after being exposed to LIF, consistent with the induction of Id2. (wustl.edu)
  • PEGLA antagonises LIF by binding towards the LIF receptor (R) Rabbit Polyclonal to p73 however, not recruiting the LIFR signalling component, IL6ST (also called gp130), stopping initiation of downstream gene transcription [20]. (cancerhugs.com)
Complexes2
  • The ability of OSM to signal via two receptor complexes conveniently offers a molecular explanation to the shared and unique effects of OSM with respect to LIF. (wikipedia.org)
  • IL-6 triggers the formation of protein complexes of gp130 and the IL-6 receptor activating the receptor. (dadamo.com)
Leukemia2
  • The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. (ox.ac.uk)
  • The structure of murine leukemia inhibitory factor (LIF) has been determined by X-ray crystallography at 2.0 A resolution. (ox.ac.uk)
Pathway3
  • Kegg pathways include: cytokine-cytokine receptor interaction, Jak- STAT signaling pathway, MAPK signaling pathway, and hematopoietic cell lineage. (cdc.gov)
  • Thus, an LIF-driven STAT3 pathway induces SOCS3, Bcl3, and Id2, which render pDCs and late DC progenitors refractory to physiological stimuli controlling pDC functions and development. (wustl.edu)
  • We can hypothesize that, in PLCA, a functional decrease in OSMRand IL-31 RA signaling pathway might bring about an increase in signaling through kind I OSM complex (LIF receptor and gp130), which could result in a peripheral neurodegenerative situation like Alzheimer's disease. (faahinhibitor.com)
Protein6
  • OSM signals through cell surface receptors that contain the protein gp130. (wikipedia.org)
  • A robust protein, OSM is stable between pH2 and 11 and resistant to heating for one hour at 56 °C. A partial amino acid sequence allowed the isolation of human OSM cDNA and subsequently genomic clones. (wikipedia.org)
  • IL-6 mediates its responses through cell surface receptors that include the transmambrane protein gp130. (dadamo.com)
  • Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. (betalifesci.com)
  • The crucial step of receptor binding depends on the closed and open conformations of the S-Protein ectodomain trimer 10 , 11 . (openaccesspub.org)
  • We further established a protein-protein interaction subnetwork for the Ccr6-correlated genes, which provides an insight on the interaction of G protein-coupled receptors, kallikrein-kinin system and neuroactive ligand-receptors. (cdc.gov)
Soluble1
  • The full cDNA clone of hOSM encodes a 252 amino acid precursor, the first 25 amino acids of which functions as a secretory signal peptide, which on removal yields the soluble 227 amino acid pro-OSM. (wikipedia.org)
OSMR2
  • This data hinted to the existence of an additional ligand specific receptor chain which led to the cloning of OSMR. (wikipedia.org)
  • Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). (joplink.net)
Antibody1
  • One important drug in this field is the anti IL- 6 receptor antibody (MRA), used as one of new therapeutic approaches in rheumatic arthritis. (dadamo.com)
Pattern recognit2
  • The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
  • ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
Residues2
  • Of the five cysteine residues within the human OSM sequence four participate in disulfide bridges, one of these disulfide bonds namely between helices A and B is necessary for OSM activity. (wikipedia.org)
  • One of the C-terminal truncated forms, the 187 residues version, showed higher stability than the native OSM (196 residues), but still demonstrated similar binding properties to the gp130-CHR. (bl.uk)
Homology1
  • Of these, LIF shows closest structural homology to granulocyte colony-stimulating factor and growth hormone (GH). (ox.ac.uk)
Binds2
  • TGF-α is related to EGF and binds to the EGF receptor, whereas TGF-β is structurally distinct from TGF-α. (antibodies-online.cn)
  • M-CSF binds to the colony stimulating factor 1 receptor. (meddic.jp)
Signals2
  • IL-6 signals through a receptor complex of IL-6 R alpha and gp130. (rndsystems.com)
  • In this study, we find that mouse pDCs selectively express the receptor for LIF that signals through STAT3. (wustl.edu)
Immunology1
  • By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. (meddic.jp)
IFNAR11
  • All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor ( IFNAR ) that consists of IFNAR1 and IFNAR2 chains. (wikidoc.org)
Genes2
  • Incidentally the genes for OSM and LIF occur in tandem on human chromosome 22. (wikipedia.org)
  • Both LIF and OSM genes have very similar gene structures sharing similar promoter elements and intron-exon structure. (wikipedia.org)
STAT33
  • This study establishes a role for monocyte/macrophages as critical regulators of osteogenic differentiation via OSM production and the induction of STAT3 signalling in MSCs. (ox.ac.uk)
  • Stimulation of pDCs with LIF inhibited IFN-I, TNF, and IL-6 responses to CpG and induced expression of the STAT3 targets SOCS3 and Bcl3, which inhibit IFN-I and NF-kB signaling. (wustl.edu)
  • Moreover, although STAT3 has been also reported to induce E2-2, LIF paradoxically induced its repressor Id2. (wustl.edu)
Inhibitor2
  • The inhibitor price TGF b receptors and their downstream transducers are usually misplaced, mutated or attenuated in human carci nomas, which include pancreatic, colon and gastric tumors. (smadpathway.com)
  • The goal of the current study was to evaluate the potential for the -adrenergic receptor inhibitor and anti-inflammatory drug, propranolol, to treat neuroinflammation in a novel long-term mouse model of GWI. (cdc.gov)
Endothelial1
  • In general cells derived from endothelial and tumour origins express high levels of OSM receptors, whereas cells of Haematopoietic origin tend to express lower numbers. (wikipedia.org)
Monocytes1
  • Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors (for example see Browning et al). (bdbiosciences.com)
Mediators2
  • These data indicate that OSM, in conjunction with other mediators, can drive MSC differentiation into OB. (ox.ac.uk)
  • Cell surface receptors for colony stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of hemopoietic cells. (rush.edu)
Intracellular1
  • It still remains unclear how OSM is targeted to these intracellular compartments. (wikipedia.org)
Signal1
  • Data (including data from studies using knockout mice) suggest that thyrotropin/thyrotropin receptor signal transduction stimulates thyroglobulin phosphorylation and contributes to enhanced de novo triiodothyronine formation in thyrocytes. (cusabio.com)
Sequence1
  • OSM most resembles LIF, bearing 22% sequence identity and 30% similarity. (wikipedia.org)
Molecular1
  • macrophages] in response to pathogen associated molecular patterns (PAMPs) binding the Toll-like Receptor (TLR) present on an active macrophage. (dadamo.com)
Mice3
  • Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice. (mpi-hlr.de)
  • LIF null feminine mice are infertile because of the failing of blastocysts to implant in to the uterus [8]. (cancerhugs.com)
  • In mice, interperitoneal (IP) shots of an extremely potent, PEGylated (conjugated to polyethylene glycol) LIF antagonist (PEGLA) through the peri-implantation period blocks endometrial epithelial LIF actions and buy BQ-788 prevents blastocyst implantation [19], producing PEGLA a appealing pharmacological contraceptive. (cancerhugs.com)
Pathways2
  • This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)
  • findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways. (cusabio.com)
Colony3
  • Receptors, Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Receptors, Colony-Stimulating Factor" by people in this website by year, and whether "Receptors, Colony-Stimulating Factor" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Receptors, Colony-Stimulating Factor" by people in Profiles. (rush.edu)
Similarities1
  • LIF and OSM have substantial functional similarities and share sort I complicated receptor. (faahinhibitor.com)
Gene1
  • These data suggest that OSM and LIF arose relatively recently in evolutionary terms by gene duplication. (wikipedia.org)
Complex2
  • CD13/gp13 functions as a part of the cytokine receptor complex. (betalifesci.com)
  • A model for receptor binding based on the structure of the GH ligand-receptor complex requires additional, novel features to account for these data. (ox.ac.uk)
Helix1
  • The three-dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. (wikipedia.org)
Cell4
  • The human form of OSM was originally isolated in 1986 from the growth media of PMA treated U-937 histiocytic lymphoma cells by its ability to inhibit the growth of cell lines established from melanomas and other solid tumours. (wikipedia.org)
  • The 196 residue OSM is the predominant form isolated form a variety of cell lines and corresponds to a glycoprotein of 28 KDa, although the larger 227 residue pro-OSM can be isolated from over transfected cells. (wikipedia.org)
  • Scatchard analysis of radio ligand binding data from 125I-OSM binding to a variety of OSM responsive cell lines produced curvilinear graphs which the authors interpreted as the presence of two receptor species, a high affinity form with an approximate dissociation constant Kd of 1-10 pM, and a low affinity form of 0.4-1 nM. (wikipedia.org)
  • Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells. (nih.gov)
Type1
  • The type I OSM receptor is capable of transducing OSM-specific signaling events. (betalifesci.com)
Human1
  • The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)
Function2
  • Thus, post translational processing may play a significant role in the in vivo function of OSM. (wikipedia.org)
  • In these sufferers, LIF expression was identified in hippocampus and inside the temporal cortex, indicating a function for LIF in neuronal damage or repair in these web sites [21]. (faahinhibitor.com)
Sites1
  • This "kink" results in a different special positioning of one extreme of the bundle to the other, significantly affecting the relative positioning of site III with sites I and II (see:Receptor recruitment sites) Receptors for OSM can be found on a variety of cells from a variety of tissues. (wikipedia.org)