Receptors of human precursor receptors laminin. Medical search. Frequent questions

The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. (embl.de)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)
In addition, the precursor cells contained various proteins of the extracellular matrix. (innovationorigins.com)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
In this study, we are interested in investigating the expression of a variety of functional classes of proteins in ESCC and its precursor lesions and characterizing the correlation of these proteins with ESCC malignant progression. (biomedcentral.com)
To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5γ2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay. (biomedcentral.com)
These zones are mainly composed of collagen IV, plectin, laminin (proteins of BM), and nidogen in the upper regions, collagen IV, VI, anchoring fibrils, and heparan sulfate proteoglycan (proteins of LD) [8]. (heraldopenaccess.us)

Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene. (wikipedia.org)
Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. (joplink.net)
Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)
The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. (embl.de)
Desk I Genes involved with beta cell proliferation Up to now five REG protein have already been reported in human beings that participate in gene family. (immune-source.com)
are laminin-like diffusible chemotactic protein involved with pancreatic morphogenesis and are likely involved in the legislation of duct-cell and foetal GSK1838705A islet cell migration. (immune-source.com)
A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human breast tumor cell line. (embl.de)
The present study aimed to establish an AD cell model overexpressing the 695‑amino‑acid Swedish mutant of Aβ precursor protein (APP695swe) in order to observe the effects of memantine on the cell viability, autophagy and apoptosis of SH‑SY5Y cells in the AD model, and to investigate the associated underlying mechanisms. (spandidos-publications.com)
Analyzing the protein expression patterns of Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC would be valuable to develop rational strategies for early detection of lesions at risk in advance as well as for prevention and treatment of ESCC. (biomedcentral.com)
The method of tissue microarray (TMA), which could confirm the results of cDNA microarray on protein level, has been popularly used for gene expression profiling in many types of cancer including ESCC, but rarely in the consecutive stages of carcinogenesis, especially in the precursor lesions. (biomedcentral.com)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)

We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)

In our continued efforts to apply Green Nanotechnology for the development of therapeutic radioactive gold nanoparticles, recently we have discovered that the high antioxidant capacity of Epigallocatechin gallate (EGCG), which is the most abundant catechin polyphenol in tea, can be used to convert radioactive Gold-198 precursor to the corresponding biocompatible radioactive gold nanoparticles functionalized with Laminin receptor specific EGCG. (sbbn.org.br)
Laminin receptors are overexpressed in a large number of human tumors and the high in vivo affinity of EGCG toward Laminin receptors has allowed to develop Laminin receptor specific radioactive gold nanoparticles to achieve tumor specificity (14). (sbbn.org.br)
Kattesh V. Katti, M.D., Ravi Shukla, M.D., and colleagues detail their studies in a paper titled "Laminin receptor specific therapeutic gold nanoparticles ( 198 AuNP-EGCg) show efficacy in treating prostate cancer. (genengnews.com)
Interaction of biocompatible EGCg with 198 Au precursor affords the production of inherently therapeutic gold nanoparticles through a novel synthetic route, effectively eliminating toxic chemicals that are routinely utilized in pharmaceutical formulations," the authors conclude. (genengnews.com)

Memantine non-competitively blocks the N-methyl-D-aspartate receptor in order to inhibit beta-amyloid (Aβ) secretion, and has been used to treat moderate-to-severe Alzheimer's disease (AD). (spandidos-publications.com)

To test therapeutic efficacy of the 198 AuNPs-EGCg in vivo the researchers established a unilateral flank model of prostate cancer derived from human PC-3 cells in SCID mice. (genengnews.com)

Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)

Secondly, the green tea extract directly and selectively binds with laminin67R receptors that are overexpressed in prostate tumor cells. (genengnews.com)
It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)

The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis. (biomedcentral.com)
Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC were analyzed using immunohistochemistry on tissue microarray containing 205 ESCC and 173 adjacent precursor lesions as well as corresponding normal mucosa. (biomedcentral.com)
They were "early" corresponding to mild and moderate DYS with overexpression of fascin, FADD and CDC25B and underexpression of Fas, caspase 8, CK4 and annexin I, "intermediate" to severe DYS and CIS with overexpression of FADD and CK14, and "late" to invasive lesions (ESCC) and to advanced pTNM stage ESCC lesions with overexpression of CK14, laminin-5γ2 and SPARC. (biomedcentral.com)
A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)
Although cDNA microarray has been successfully used to explore the gene expression in ESCC, it is difficult to be used in the precursor lesions due to the difficulty to obtain the dysplastic cells accurately. (biomedcentral.com)
[ 5 ] The investigators found "an arbitrary continuum of morphologic structure links normal [TDLUs] and/or lobules to the entire group of dysplastic, metaplastic, hyperplastic, anaplastic, and neoplastic human mammary lesions, with the exception of intraductal papillomas and rarely occurring hyperplasias of larger ducts. (medscape.com)
An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. (medscape.com)

Surprisingly, the related cytokine, CNTF, was less potent than LIF in increasing the NSCs and more potent than LIF in increasing the PDGF responsive multipotential precursors. (karger.com)

While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has prolonged effect due to covalent binding to the receptor. (helsinki.fi)

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)

The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
showed that Linefade could significantly induce collagen IV in cell culture models of Human Dermal Fibroblasts (HDFs) and epidermal skin explants [8]. (heraldopenaccess.us)

Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. (tamu.edu)
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. (tamu.edu)
however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)

7 In contrast, alternatively activated macrophages are characterized by increased expression of IL-10 and of scavenger receptors. (haematologica.org)

The proto-oncogene designated erbB2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185erbB2), whose overexpression has been correlated with a poor prognosis in several human malignancies. (embl.de)

It is mediated by the contact of the precursor cell with the extracellular matrix and the mechanosensitive gene regulator YAP . (innovationorigins.com)

We combined in-depth analysis of chaperone genes in human datasets, analysis of a neuronal cell line lacking STI1 and of a mouse line with a hypomorphic Stip1 allele to investigate the requirement for STI1 in aging. (bvsalud.org)
Genes and pathways associated with lactation number in cows were identified for the first time to date, and we found that many were comparable to those known to be associated with ageing in humans and model organisms. (biomedcentral.com)
Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)

Diabetes mellitus (DM) is an incurable metabolic disease constituting a major threat to human health. (biomedcentral.com)
Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism, which constitutes a major threat to human health worldwide, particularly in industrialized countries. (biomedcentral.com)

Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane. (lookformedical.com)

UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)

Analysis of human databases revealed a subset of co-chaperones, including STI1, whose loss of function is incompatible with life in mammals, albeit they are not essential in yeast. (bvsalud.org)
To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)

It is particularly exciting for us that our data answer a question that has been driving our field of research for decades," says Henrik Semb, explaining how some precursors mature into scaffold cells, while others become endocrine cells through activation of the so-called Notch signaling pathway. (innovationorigins.com)

In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
1 Some tissue macrophages and precursors are already established embryonically in the yolk sac and fetal liver before the onset of definitive hematopoiesis. (haematologica.org)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)

Previous studies have identified many immune pathways which are consistently altered in humans and model organisms as they age. (biomedcentral.com)

Activity assays were conducted using recombinant enzymes as well as human liver and intestinal microsomes. (helsinki.fi)

Also functions as a cell surface receptor for laminin. (joplink.net)
We have now succeeded in working out the basic signals that decide whether a precursor cell develops into an endocrine - i.e. hormone-producing - or a scaffold cell," said Prof. Dr. Henrik Semb. (innovationorigins.com)
The two scientists found that the components of the extracellular matrix send a signal into the cell using an integrin receptor. (innovationorigins.com)
This signal influences the development of the precursor cell. (innovationorigins.com)
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. (nih.gov)

These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)

De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST and Klein WL: Abeta oligomers induce neuronal oxidative stress through an N- methyl- d - aspartate receptor- dependent mechanism that is blocked by the Alzheimer drug memantine. (spandidos-publications.com)

Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)

In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)

Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)

MSCs were isolated from human umbilical cord (UC-MSCs) and expanded in an in vitro culture system. (biomedcentral.com)

Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. (tamu.edu)
Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)

These two pathologies may be present at the same time in human lungs and in mice either instilled with elastolytic enzymes or bleomycin or exposed to cigarette-smoke. (biomedcentral.com)

The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)

With the recent discovery that adult olfactory bulb neurogenesis in the human brain likely ceases after 18 months of age, there is increased interest in studying the NPs of the neonate [ 1 ]. (karger.com)

Gain of function studies showed that LIF increased the abundance of these precursors. (karger.com)

WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
To do this, they applied precursor cells to glass plates. (innovationorigins.com)
This enables us to simulate this process in the laboratory and try to produce insulin-producing beta cells cost-effectively and reliably from human stem cells. (innovationorigins.com)

Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)

It is also a common resident of the human gastrointestinal tract and has been associated with inflammatory bowel disease. (nature.com)
F. nucleatum is also a common resident of the human gastrointestinal tract 12 . (nature.com)
In read The New Kinship: Constructing Donor Conceived, there is no extensor self-induced, special, Gastrointestinal or human Tungdil pitting adolescents from effects. (runkwitz.com)

Predicted to enable signaling receptor binding activity. (nih.gov)

Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (joplink.net)

Anatomy14

Organisms4

Diseases2

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Proteins8

Protein13

Neural precursors2

Gold nanoparticles4

Beta-amyloid1

EGCG1

Thrombospondin1

Binds2

Lesions7

PDGF1

Affinity1

Agonist2

Collagen3

Regulation5

Scavenger1

Overexpression1

Gene1

Genes3

Metabolic2

CASPASE1

Differentiation2

Subset2

Endocrine cells1

Tissue2

Endothelial cells1

Interaction1

Pathways1

Recombinant1

Cell5

Adhesion2

Mechanism1

Specific1

Contrast1

Membrane1

Tissues1

Umbilical1

Dependent3

Enzymes1

Origins1

Brain1

Gain1

Cells4

Expression1

Gastrointestinal3

Activity1

Mature1