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  • Responses
  • Responses were observed to both cuticular hydrocarbon components, some of which are known pheromones, and "general odorants," demonstrating broad coverage of these odor spaces across several subfamilies of receptors. (pnas.org)
  • Responses to several classes of semiochemicals are described, including cuticular hydrocarbons and mandibular gland components that act as H. saltator pheromones, and a range of more traditional general odorants. (pnas.org)
  • When viewed through the prism of caste-specific OR enrichment and distinctive OR subfamily odorant response profiles, our findings suggest that whereas individual HsOr s appear to be narrowly tuned, there is no apparent segregation of tuning responses within any discrete HsOr subfamily. (pnas.org)
  • Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. (nih.gov)
  • While a considerable amount of information has been generated regarding ORN responses to odorants, the role of specific ORNs in driving behavioral responses remains poorly understood. (readbyqxmd.com)
  • Odorant- and cAMP-induced responses showed the same adaptation in a Ca2+-dependent manner, indicating that adaptation occurs entirely downstream of the cyclase. (nih.gov)
  • Regulates
  • TIR-1 localizes NSY-1 to post-synaptic regions of AWC, and TIR-1 binds UNC-43, suggesting that it assembles a synaptic signaling complex that regulates odorant receptor expression. (nih.gov)
  • putative
  • RT-PCR and RACE performed on total RNA isolated from catfish olfactory epithelium produced a cDNA that is very similar to metabotropic glutamate receptors and putative pheromone receptors from multiple species. (lsu.edu)
  • However, it is still unknown whether these putative mechanisms work in the intact olfactory receptor cell. (nih.gov)
  • Molecular
  • To better understand the molecular mechanisms by which chemoreceptors regulate social behaviors, we investigated the roles of a critical class of chemoreceptors, the odorant receptors (ORs), from the ponerine ant Harpegnathos saltator in detecting cuticular hydrocarbon pheromones. (pnas.org)
  • pheromone receptors
  • Most moth sex pheromones are C 10 -C 18 acetates, alcohols, and aldehydes (Type I pheromones), and most pheromone receptors (PRs) characterized to date are from higher Lepidoptera (Ditrysia), responding to these types of compounds. (lu.se)
  • acetates, alcohols, and aldehydes (Type I pheromones), and most pheromone receptors (PRs) characterized to date are from higher Lepidoptera (Ditrysia), responding to these types of compounds. (lu.se)
  • Is the Subject Area "Pheromone receptors" applicable to this article? (plos.org)
  • ORNs
  • Complications in behavior analyses arise due to different volatilities of odorants that activate individual ORNs, multiple ORNs activated by single odorants, and the difficulty in replicating naturally observed temporal variations in olfactory stimuli using conventional odor-delivery methods in the laboratory. (readbyqxmd.com)
  • Orco functions as a non-selective cation channel and is expressed in the majority of olfactory receptor neurons (ORNs). (vanderbilt.edu)
  • In addition, a functional internalization event was identified specifically upon odorant stimulation in isolated catfish ORNs. (lsu.edu)
  • Functional
  • The missense of smell: functional variability in the human odorant receptor repertoire. (nih.gov)
  • On average, two individuals have functional differences at over 30% of their odorant receptor alleles. (nih.gov)
  • Hence, our definition of the monophyletic lepidopteran PR-clade includes these receptors from a non-ditrysian species, based on functional support. (lu.se)
  • By using a functional genomics approach, we have identified a honey bee [Apis mellifera (Am)] odorant receptor (Or) for the queen substance 9-oxo-2-decenoic acid (9-ODA). (semanticscholar.org)
  • OSNs
  • OSNs expressing the same OR send convergent axonal projections to defined glomeruli in the OB and are thought to share the same odorant response properties. (jneurosci.org)
  • The glomerular convergence of afferents that express a given OR strongly suggests that glomeruli integrate inputs from OSNs that share similar odorant response profiles ( Kauer, 1987 ). (jneurosci.org)
  • activation
  • However, translating these data into an understanding of in vivo OR activation by odorants is difficult. (jneurosci.org)
  • We have described and characterized the first Orco antagonist, that is capable of non-competitively inhibiting odorant-evoked activation of OR complexes, thereby providing additional insight into the structure/function of this unique family of ligand-gated ion channels. (vanderbilt.edu)
  • Currently, little is known about how changes in the receptor activation pattern alter olfactory perception. (grantome.com)
  • orco
  • While many natural and synthetic odorants have been shown to agonize Orco/Or complexes, only a single direct Orco modulator, VUAA1, has been described. (vanderbilt.edu)
  • assay
  • to assay instead simultaneously the entire repertoire of ORs so that sets of ORs activated by odorants may be identified. (jneurosci.org)
  • axonal
  • Our data provide evidence that ORs determine both odorant specificity and axonal convergence and thus direct functionally similar afferents to form particular glomeruli. (jneurosci.org)
  • Replacing the OR at a genetic locus changes odorant responsiveness and concomitantly shifts the site of axonal convergence. (jneurosci.org)
  • clade
  • With few exceptions, functionally characterized PRs fall into what has been called the "PR-clade" which also contains receptors that have yet to be characterized. (lu.se)