• A new study, however, shows that pharmacological stimulation of a specific type of nicotinic receptor in cells of the immune system could be a strategy to treat inflammatory lung disease. (eurekalert.org)
  • In this case, the therapeutic effect is associated with activation of nicotinic receptors of the alpha-7 subtype in macrophages, the immune system's first-line cells that are central to the inflammatory response to a potential threat. (eurekalert.org)
  • Although there was little difference between S -(+)-mecamylamine and R -(−)-mecamylamine in terms of 50% inhibition concentration values for a given receptor subtype, there appeared to be significant differences in the off-rates for the mecamylamine isomers from the receptors. (aspetjournals.org)
  • Seven of these genes, including the nicotinic receptor subunit genes unc-29, unc-38 , and lev-1 , were essential for the stimulation of egg laying by levamisole, though they had only subtle effects on egg-laying behavior in the absence of drug. (genetics.org)
  • Greater accumulation of beta amyloid "plaques" was accompanied by a reduction in neuronal nicotinic receptors - brain molecules crucial to memory function. (thefreedictionary.com)
  • with its simple well-characterized nervous system and its amenability to classical and molecular genetic studies, is well suited for investigating how specific neurotransmitters, receptors, and signaling molecules function within the context of the nervous system to produce behavior. (genetics.org)
  • More important than their historical role, nicotinic receptors continue to be at the forefront of science, as they are drug targets for muscle and nerve diseases, such as Alzheimer's and Parkinson's diseases, Schizophrenia and Myasthenia gravis. (intechopen.com)
  • Based on these findings, the group at UNIFESP decided to test the hypothesis that stimulating the cholinergic system with a drug that binds to nicotinic receptors might attenuate inflammation in the lungs of mice that had not been genetically modified so as not to express VAChT. (eurekalert.org)
  • In addition, since expression of functional unc-29 in muscle cells restored levamisole sensitivity under some but not all conditions, both neuronal and muscle cell UNC-29 receptors are likely to contribute to the regulation of egg-laying behavior. (genetics.org)
  • Here we describe the egg-laying phenotypes of eight levamisole resistance genes, which affect the activity of levamisole-sensitive nicotinic receptors in nematodes. (genetics.org)
  • Thus, these genes appear to encode components of a nicotinic receptor that can promote egg laying but is not necessary for egg-laying muscle contraction. (genetics.org)
  • MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic ( ChrnB2 and ChrnB4 ) receptor genes, which is impaired in patients with type 2 diabetes. (antikoerper-online.de)
  • Specifically, S -(+)-mecamylamine appeared to dissociate more slowly from α4β2 and α3β4 receptors than did R- (−)-mecamylamine. (aspetjournals.org)
  • In addition, it was found that muscle-type receptors appeared to be somewhat more sensitive to R- (−)-mecamylamine than to S- (+)-mecamylamine. (aspetjournals.org)
  • Together, these findings suggest that in chronic (i.e., therapeutic) application, S- (+)-mecamylamine might be preferable to R- (−)-mecamylamine in terms of equilibrium inactivation of neuronal receptors with decreased side effects associated with muscle-type receptors. (aspetjournals.org)
  • With their quick-fire means of function, ionotropic receptors are in contrast with metabotropic receptors. (wisegeek.com)
  • Metabotropic receptors send their biological messages through the cell using a somewhat slower diffusion of chemicals throughout the body of the cell in which the receptor is located. (wisegeek.com)
  • Rahman S. Nicotinic receptors as therapeutic targets for drug addictive disorders. (springer.com)
  • Dextromethorphan (DM) is structurally closely related to levorphanol, codeine, and morphine, but unlike these opiates it has low affinity for opiate receptors and is not considered to be addictive. (aspetjournals.org)
  • The term "silent agonists" is introduced to describe receptor ligands that bind to the conventional acetylcholine binding site, do not initiate ion channel activity, and place the receptor in a desensitized state that can be revealed in the presence of a type II positive allosteric modulator. (ufl.edu)
  • A receptor is a part of a cell that attaches to certain chemicals in a process called binding, which triggers the cell to react within the body. (wisegeek.com)
  • These results indicate that there is an increase in receptor heterogeneity and complexity in chick retina during development that is also maintained in adulthood. (nih.gov)