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  • antibody-dependent ce
  • Once activated, NK lymphocytes kill tumor cells via FcgRIIIA (CD16) which can trigger antibody-dependent cellular cytotoxicity (ADCC) on encountering target cells opsonized with IgG, via the Fas/Fas-L pathway and via cytotoxic granules (perforin/granzyme) secretion ( 1 , 8 ). (frontiersin.org)
  • Further, NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) is a main immune-dependent mechanism by which tumor-targeting therapeutic mAbs mediate tumor cell killing [ 6 - 8 ]. (hindawi.com)
  • interferon
  • Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor ROR α and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor ROR γ t and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon- γ . (hindawi.com)
  • cytokines
  • Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. (hindawi.com)
  • lysis
  • In this study, we selected the BAB281 monoclonal antibody (mAb) on the basis of its ability to trigger NK-mediated target cell lysis. (nih.gov)
  • Cell
  • In addition to modulate functional responsiveness, NK cell inhibitory receptors are critical for promoting their education [ 9 ]. (hindawi.com)
  • There were 3 discrete subsets of DLBCL-"oxidative phosphorylation," "B-cell receptor/proliferation," and "host response" (HR)-identified characterized using gene set enrichment analysis and confirmed in an independent series. (bloodjournal.org)
  • HR tumors had increased expression of T/natural killer cell receptor and activation pathway components, complement cascade members, macrophage/dendritic cell markers, and inflammatory mediators. (bloodjournal.org)