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  • subunits
  • Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits. (neuromics.com)
  • The receptor tetramers in erythroid precursor cells are composed of the NR1, NR2A, 2C, 2D, NR3A, and 3B subunits of which the glycine-binding NR3A and 3B and glutamate-binding NR2C and 2D subunits prevailed. (uzh.ch)
  • NMDARs
  • D-serine, the D-stereoisomer of serine, synthesized in the brain by serine racemase from its L-stereoisomer is considered a co-agonist I co-activator of glutamatergic N-methyl-0-aspartate receptors (NMDARs). (fsu.edu)
  • 3. D-serine's antagonism of GluN3-containing triheteromeric NMDARs may be important because these receptors appear significantly more permeable 1 selective for calcium, a potent excitotoxicant that underlies cell death under a number of scenarios including epilepsy. (fsu.edu)
  • 15 Therefore, serine phosphorylation represents a major posttranslational modification for NMDARs in their fundamental regulation of the receptor function. (asahq.org)
  • antagonist
  • Mohammed Naeem, Hala Al Alem, Ali Al Shehri, and Majed Al-Jeraisy, "Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit," Pain Research and Management , vol. 2016, Article ID 1658172, 7 pages, 2016. (hindawi.com)
  • Receptor activity was monitored using a radiolabeled antagonist binding assay, live imaging of Ca(2+) uptake, patch clamp, and monitoring of cell volume changes. (uzh.ch)
  • oocytes
  • Concentration-response curves for the effects of flurothyl on oocytes expressing either NR1/2A, NR1/2B or GABA A α 1 /β 1 /γ 2s receptors. (nih.gov)
  • phosphorylation
  • 16,17 As a negative regulator of protein phosphorylation, PP2A plays a key role in the dephosphorylation of various phosphoproteins (receptors, enzymes, structural proteins, and others) in relation to many fundamental cellular activities. (asahq.org)
  • protein-coupled
  • The interaction of clozapine with many G protein-coupled receptors is well documented but less is known about its biologically active metabolite, N -desmethylclozapine. (pnas.org)
  • potent
  • N -desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC 50 of 55 nM and was a more potent partial agonist (EC 50 , 115 nM and 50% of acetylcholine response) at this receptor than clozapine. (pnas.org)
  • pharmacological
  • Furthermore, pharmacological and site-directed mutagenesis studies suggested that N -desmethylclozapine preferentially activated M1 receptors by interacting with a site that does not fully overlap with the acetylcholine orthosteric site. (pnas.org)
  • activation
  • Activation of the receptor results in the transient Ca(2+) accumulation, cell shrinkage, and alteration in the intracellular pH, which is associated with the change in hemoglobin oxygen affinity. (uzh.ch)
  • significantly
  • Expression levels of phosphorylated N-methyl-D-aspartate receptor (pNR)1 and pNR2B were significantly increased in the dorsal root ganglion of FM model mice (132.21±14.4% and 116.69±3.22% of control values), whereas NR1 and NR2B levels were unchanged (97.31±3.79% and 97.07%±2.27%, respectively). (bmj.com)
  • Among nine genes examined, the expression of the oxytocin receptor was significantly lower in the prefrontal cortex of GluN3A KO mice than that in WT mice. (autismcandles.com)
  • selective
  • Analysis of paired evoked α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid EPSCs and spontaneous mEPSCs indicated that withdrawal after chronic exposure was also associated with a selective increase in action potential evoked but not spontaneous transmitter release probability. (aspetjournals.org)