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  • GRM5
  • Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. (thefullwiki.org)
  • Ligand
  • We determined the crystal structure of the entire extracellular region of the group II receptor and that of the ligand-binding region of the group III receptor. (pnas.org)
  • We propose a general activation mechanism of the dimeric receptor coupled with both ligand-binding and interprotomer rearrangements. (pnas.org)
  • Therefore, structural information about the receptor-ligand interaction is essential for drug development. (pnas.org)
  • Ligand binding studies have revealed that the basal ganglia contain at least two pharmacological types of metabotropic binding sites. (jneurosci.org)
  • GRM1
  • Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. (nih.gov)
  • stimulate
  • The structure also reveals the lateral interaction between the two cysteine-rich domains, which could stimulate clustering of the dimeric receptors on the cell surface. (pnas.org)
  • In expression systems, Group-I receptors, stimulate phospho-lipase C and Ca2+ release from internal stores. (acris-antibodies.com)