• Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta. (mpg.de)
  • Functional olfactory sensory neurons housed in olfactory sensilla on the ovipositor of the hawkmoth Manduca sexta. (mpg.de)
  • A reference gene set for chemosensory receptor genes of Manduca sexta. (mpg.de)
  • The plastic response of Manduca sexta to host and non-host plants. (mpg.de)
  • Chemosensory receptors in the tobacco hawkmoth Manduca sexta. (mpg.de)
  • Searching for the Right One: Investigating Manduca sexta Pheromone Receptors. (mpg.de)
  • Incubation of Cry1Ab protoxin with a single chain antibody that mimics the cadherin-like receptor and treatment with Manduca sexta midgut juice or trypsin, resulted in toxin preparations with high pore-forming activity in vitro. (unboundmedicine.com)
  • For the investigation of the biocompatibility and functionality of the layer systems two types of neurons will be used, namely pacemaker neurons of the cockroach Rhypharobia maderae and olfactory receptor neurons from the tobacco hornworm Manduca sexta which serve as models for the investigation of the spontaneous electrical activity and the directional growth of developing neuronal networks, respectively, both aiming at long-term studies, not achieved till now with other materials. (uni-kassel.de)
  • We also visualized the conservation of interaction networks in the orexin 2 receptor binding site by building homology models of the putative orexin receptor of Ciona intestinalis and the allatotropin receptor of Manduca sexta. (helsinki.fi)
  • Manduca sexta vitellogenin is a phosphoglycolipoprotein (Mᵣ ∼ 500,000) that contains two copies of the apoproteins (apovitellogenin-I, Mᵣ 180,000 and apovitellogenin-II Mᵣ 45,000), 13 percent lipids, 3 percent carbohydrates and 0.6 percent phosphorus. (arizona.edu)
  • We have identified a novel guanylyl cyclase, named MsGC-I, that is expressed in the nervous system of Manduca sexta. (elsevierpure.com)
  • A classic example of such programming is reflected in the study of Manduca sexta (Lepidoptera: Sphigidae) by Lynn Riddiford and her colleagues[ 5 , 6 ]. (biomedcentral.com)
  • Earlier results shown in Manduca sexta were confirmed and it was shown that soluble hemolin has a deaggregating effect on naive hemocytes of H. cecropia. (diva-portal.org)
  • In contrast to eggplant ( Solanum melongena ), tomato ( S. lycopersicum ) does not respond to FACs present in OS from Manduca sexta (Lepidoptera). (springer.com)
  • Inka cells (or peritracheal cells) were first discovered in Manduca sexta in 1996 (Zitnan et al. (neurostresspep.eu)
  • 2003). It might be a similar case in M. sexta where two receptor variants exist (Kim et al. (neurostresspep.eu)
  • 2013. Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: Evidence from Manduca sexta and Blattella germanica . (upf-csic.es)
  • A single M. sexta predicted gene Toll-like Receptor (TLR) custom synthesis clustered with TrpA1 from other insects and shares 59 amino acid identity with dTrpA1. (igf-1r.com)
  • The method had been used in previous studies to transplant female antenna of the Manduca sexta moth onto male moths and, in Vickers' lab, to study antennae transplanted from another moth species onto H. virescens . (utah.edu)
  • Given the distinct differences at expression level and the ligand-binding capacity, we hypothesis that PxEcRB is the ecdysone receptor that controls the remodeling events during metamorphosis. (biomedcentral.com)
  • Two widely distributed lepidopteran herbivores, codling moth Cydia pomonella (Tortricidae) feeding in apples and pears, and the African cotton leafworm Spodoptera littoralis (Noctuidae), a moth feeding on foliage of a wide range of herbaceous plants, both express a receptor ortholog, OR19, which shares 58% amino acid identity and 69% amino acid similarity. (frontiersin.org)
  • In the moth Manduca and the cricket Acheta ,functional studies have shown that its cognate receptor (DH-R) is related to the mammalian CRF receptor. (silverchair.com)
  • The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a devastating pest of cruciferous crops worldwide, and has developed resistance to a wide range of insecticides, including diacylhydrazine-based ecdysone agonists, a highly selective group of molt-accelerating biopesticides targeting the ecdysone receptors. (biomedcentral.com)
  • In a normal H. subflexa moth, the antennal receptors for each odorant connect to their own distinct glomerulus. (utah.edu)
  • Show that sensory receptors send messages to the brain. (brainu.org)
  • In insects, plate, so that its hairs are continuously deflected, prevents the different classes of sensory receptors act in parallel to signal transition from stance to swing by maintaining the leg in any change that occurs in the position of a leg joint. (docslib.org)
  • The research team can activate single receptor neurons out of 28 olfactory neurons in the larvae for this sensory perception. (sciencedaily.com)
  • Olfactory receptor neurons. (lookformedical.com)
  • Neurons in the OLFACTORY EPITHELIUM with proteins ( RECEPTORS, ODORANT ) that bind, and thus detect, odorants. (lookformedical.com)
  • Proteins, usually projecting from the cilia of olfactory receptor neurons , that specifically bind odorant molecules and trigger responses in the neurons . (lookformedical.com)
  • The ability to detect scents or odors , such as the function of OLFACTORY RECEPTOR NEURONS . (lookformedical.com)
  • It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB . (lookformedical.com)
  • Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. (lookformedical.com)
  • A ubiquitous, cytoplasmic protein found in mature OLFACTORY RECEPTOR NEURONS of all VERTEBRATES. (lookformedical.com)
  • The Splice Isoforms of the Drosophila Ecdysis Triggering Hormone Receptor Have Developmentally Distinct Roles. (neurostresspep.eu)
  • Two subtypes of ecdysis-triggering hormone receptor in Drosophila melanogaster . (neurostresspep.eu)
  • 2012. Functional characterization of hypertrehalosemic hormone receptor in relation to hemolymph trehalose and to oxidative stress in the cockroach Blattella germanica . (upf-csic.es)
  • glycoprotein hormone receptor [Crass. (nig.ac.jp)
  • Three GPCRs clustered with recently identified putative CHH receptors (CHHRs), and differential expression over the molt cycle suggests that they are associated with ecdysteroidogenesis regulation. (biomedcentral.com)
  • Two putative Corazonin receptors showed much higher expression in the YOs compared with all other GPCRs, suggesting an important role in molt regulation. (biomedcentral.com)
  • Three putative CHH receptors were identified and could include an MIH receptor whose activation negatively regulates molting. (biomedcentral.com)
  • Odorant receptors (ORs) interface animals with airborne chemical signals. (frontiersin.org)
  • Our results demonstrate a conserved function of an odorant receptor in two moths that are phylogenetically and ecologically distant. (frontiersin.org)
  • These neurons send their DENDRITES to the surface of the epithelium with the odorant receptors residing in the apical non-motile cilia . (lookformedical.com)
  • The large number of different odorant receptors appears to arise from several gene families or subfamilies rather than from DNA rearrangement. (lookformedical.com)
  • In exploring the neural wiring between receptors, glomeruli and downstream connections to higher brain centers, Vickers and Lee found that the transplanted odorant receptors still connected to distinct glomeruli, although not in the same locations as in normal moths. (utah.edu)
  • Here, we identify structurally conserved regions at the predicted binding site and conserved residues of the orexin-A peptide by comparing orexin 2 receptor sequences from nine diverse species as well as with insect allatotropin receptor, a distant relative, and orexin-A sequences from 10 different species. (helsinki.fi)
  • Sequence comparison and phylogenetic analysis showed striking conservations among insect ecdysone receptors, especially between P. xylostella and other lepidopterans. (biomedcentral.com)
  • Complex steroid-peptide-receptor cascade controls insect ecdysis. (neurostresspep.eu)
  • Molecular identification of the first insect ecdysis triggering hormone receptors. (neurostresspep.eu)
  • 2009). We BLAST searched the total predicted protein set generated by the Manduca genome project, using previously reported insect TrpA and TrpN sequences as queries. (igf-1r.com)
  • The Drosophila genome contains two genes( CG8422 and CG1237 0) orthologous to Manduca and Acheta DH-Rs. (silverchair.com)
  • The ETH receptor is homologous to vertebrate neuromedin U receptors (Jékely, 2013). (neurostresspep.eu)
  • we therefore tested for cannabinoid receptors in seven representative species, using tritiated ligand binding assays with [3H]CP55,940 displaced by the CB1-selective antagonist SR141716A. (researchgate.net)
  • MsGC-I shows highest sequence identity with receptor guanylyl cyclases throughout its catalytic and dimerization domains but does not contain the ligand-binding, transmembrane, or kinase-like domains characteristic of receptor guanylyl cyclases. (elsevierpure.com)
  • For EcR, the LBD plays roles in receptor dimerization, ligand recognition and cofactor interactions. (biomedcentral.com)
  • 2002). Two transcript variants of the receptor are present in D. melanogaster and the receptor variants show differences in ligand sensitivity, cellular distribution and have distinct roles in development (Diao et al. (neurostresspep.eu)
  • Orthologs of receptors that were found to be involved in molt regulation in insects were also identified, including LGR3 and Corazonin receptor, the latter of which was expressed at much higher level than all other receptors, suggesting a key role in YO regulation. (biomedcentral.com)
  • G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. (biomedcentral.com)
  • The binding affinity of ecdysteroids to in vitro- translated receptor proteins indicated that PxEcRB isoform bound specifically to ponasterone A, and the binding affinity was enhanced by co-incubation with PxUSP ( K d =3.0±1.7 nM). (biomedcentral.com)
  • Bernays, E.A., Chapman, R.F. & Hartmann, T. 2002 A taste receptor cell dedicated to the perception of pyrrolizidine alkaloids in two species of polyphagous arctiids. (elizabethbernays.com)
  • To develop new therapeutics, understanding the interactions between the orexin peptides and their cognate receptors is crucial. (helsinki.fi)
  • The three-dimensional arrangement of the orexin-A peptide complexed to its cognate orexin-2 receptor has so far remained elusive. (helsinki.fi)
  • The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis. (silverchair.com)
  • The first ETH receptor (CG5911) was de-orphanized in Drosophila melanogaster (Iversen et al. (neurostresspep.eu)
  • Target site insensitivity, in which the altered binding of insecticides (ecdysone agonists) to their targets (ecdysone receptors) leads to an adaptive response (resistance), is one of the underlying mechanisms of diacylhydrazine resistance. (biomedcentral.com)
  • The role of receptor interaction in the process of protoxin activation was analyzed. (unboundmedicine.com)
  • These results suggest that the uptake of vitellogenin involves binding to specific receptors on follicle membranes and the carbohydrate moiety and apovitellogenin-II are not involved in the interaction with the receptors. (arizona.edu)
  • It was then demonstrated that both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. (sdbonline.org)
  • These visceral muscle contractions are induced by immune reactive oxygen species (ROS) that accumulate in the lumen and depend on the ROS-sensing TRPA1 receptor. (sdbonline.org)
  • Each species develops receptors to pick up only the odorants that they're interested in, preventing the costly mistakes of misidentifying females. (utah.edu)
  • We show that both a transcript and a protein of the sizes predicted from the MsGC-I cDNA are present in the nervous system of Manduca and that MsGC-I is expressed in a small population of neurons within the abdominal ganglia. (elsevierpure.com)
  • The orexin system is an important regulator of the sleep/wake cycle, and small molecule agonists of the orexin receptors could be beneficial for patients suffering from type 1 narcolepsy. (helsinki.fi)
  • Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes. (famri.org)
  • On the other hand, alkyl substituents at position 2 and 3 of the five-membered ring increased the response indicating a higher complementarity with the receptor cavity, in both CpomOR19 and SlitOR19. (frontiersin.org)
  • The C domain, the central DNA-binding domain (DBD), contains two highly conserved zinc finger motifs that are characteristic of the nuclear receptor superfamily (NRs). (biomedcentral.com)
  • Phylogenetic analysis classified 49 as class A (Rhodopsin-like receptor), 35 as class B (Secretin receptor), and 9 as class C (metabotropic glutamate). (biomedcentral.com)
  • Couto D, Zipfel C (2016) Regulation of pattern recognition receptor signalling in plants. (springer.com)
  • The release of Ca 2+ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP 3 R) occurs in both excitable and nonexcitable cells. (jneurosci.org)
  • Here, we present multiple lines of evidence to support the hypothesis that the orphan CG8422 G-protein-coupled receptor is a functional DH-R. When expressed in mammalian cells, CG8422 conferred selective sensitivity to DH, as indicated by translocation of aβ-arrestin-2-GFP reporter from the cytoplasm to the cell membrane. (silverchair.com)
  • Our discovery of cannabinoid receptors in some nematodes, onychophorans, and crustaceans does not contradict the Ecdysozoa hypothesis, but gives it no support. (researchgate.net)
  • Note that the top graph is with no alkaloid, and the second to top graph displays a response to an extremely low concentration, more like the sensitivity of a smell receptor, and those below show responses at increasing concentrations. (elizabethbernays.com)
  • In addition, MsGC-I contains a C-terminal extension of 149 amino acids that is not present in other receptor guanylyl cyclases. (elsevierpure.com)
  • In this study, we cloned and characterized the ecdysone receptors from P. xylostella , including the two isoforms of EcR and a USP. (biomedcentral.com)
  • Insects have become useful models for the study of innate immune mechanisms, due to their lack of antibodies and receptors involved in adaptive immune response. (diva-portal.org)
  • The presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. (researchgate.net)
  • G protein-coupled receptor 48 [Ratt. (nig.ac.jp)
  • We hypothesize that cannabinoid receptors evolved in the last common ancestor of bilaterians, with secondary loss occurring in insects and other clades. (researchgate.net)
  • The type III TGF-β receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease γ-secretase. (nih.gov)