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  • chemokine receptors
  • For the adoptive transfer of tumor-directed T lymphocytes to prove effective, there will probably need to be a match between the chemokines the tumor produces and the chemokine receptors the effector T cells express. (nih.gov)
  • Chemokine receptors as therapeutic tools in Hodgkin lymphoma: CCR4 and beyond. (nih.gov)
  • Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. (nih.gov)
  • In agreement with the differential chemokine receptor expression, Th1s and Th2s selectively migrate in response to the corresponding chemokines.The differential expression of chemokine receptors may dictate, to a large extent, the migration and tissue homing of Th1s and Th2s.It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors. (nih.gov)
  • Here we report that among four CXC (CXCR1-4) and five CC (CCR1-5) chemokine receptors analyzed, CXCR3 and CCR5 are preferentially expressed in human Th1s. (nih.gov)
  • The differential expression of chemokine receptors may dictate, to a large extent, the migration and tissue homing of Th1s and Th2s. (nih.gov)
  • To assess the selective expression of chemokine receptors in the different T cell subsets, we have analyzed the messenger RNA (mRNA) expression levels for the different chemokine receptors in both Th1 and Th2 lines, as well as in naive cells. (nih.gov)
  • As shown in Fig. 2, polarized Th1s and Th2s showed differential expression of chemokine receptors. (nih.gov)
  • tumor
  • Tumor HEVs were specifically located within lymphocyte-rich areas, and their density within the tumor stroma was a strong predictor of infiltration by CD3 + and CD8 + T cells as well as B cells. (aacrjournals.org)
  • Together, our findings suggest that tumor HEVs function as major gateways for lymphocyte infiltration into human tumors, and may represent attractive targets for cancer diagnosis and therapy. (aacrjournals.org)
  • The presence of high numbers of tumor-infiltrating lymphocytes, particularly T cells, has been found to be a major predictor of favorable clinical outcome in several solid cancers, including colorectal ( 5-7 ), lung ( 8 ), and ovarian carcinomas ( 9-11 ). (aacrjournals.org)
  • In contrast, the characteristics of tumor blood vessels which facilitate large-scale influx of lymphocytes within human tumors are presently unknown. (aacrjournals.org)
  • Hyaluronate
  • ab25224 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells. (abcam.com)
  • Integrins
  • Our demonstration of integrin adhesive activity regulated through receptor diffusion/clustering (rather than through altered ligand binding affinity) may be highly relevant towards the understanding of inside-out signaling mechanisms for beta1 integrins. (nih.gov)
  • thymus
  • The Reed-Stemberg cells of Hodgkin lymphoma (HL) predominantly produce thymus- and activation-regulated chemokine/CC chemokine ligand 17 (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), which preferentially attract type 2 T helper (Th2) cells and regulatory T cells (Tregs) that express the TARC/MDC-specific chemokine receptor CCR4, thus generating an immunosuppressed tumor environment. (nih.gov)
  • tissues
  • Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. (bioportfolio.com)
  • This finding is consistent with the view that SDF-1, constitutively expressed in a broad range of tissues, is involved in basal trafficking of naive lymphocytes (27). (nih.gov)
  • High endothelial venules (HEV) are blood vessels found in lymphoid tissues, specialized in lymphocyte recruitment, but their implications in human cancer are unknown. (aacrjournals.org)
  • leukocytes
  • This chapter will focus on the properties of P-selectin (CD62, formerly GMP-140 or PADGEM), a receptor that supports binding of leukocytes to activated platelets and endothelium. (springer.com)
  • peripheral
  • Immunohistochemical analysis of c-kit receptor expression on freshly prepared human peripheral blood buffy coats. (nih.gov)
  • human
  • We generated Th1 and Th2 lines by stimulating human cord blood lymphocytes with mitogen in the presence of IL-12 and neutralizing anti-IL-4 mAb or IL-4 and neutralizing anti-IL-12 mAb, respectively. (nih.gov)
  • In the present study, we investigated the presence of HEVs within various human primary solid tumors and their association with lymphocyte infiltration, immune orientation, and clinical outcome in breast cancer. (aacrjournals.org)
  • activation
  • CCR1 (regulated on activation, normal T cell expressed and secreted [RANTES], MIP-1α, MCP-3 receptor) was equally expressed in Th1s and Th2s. (nih.gov)
  • CCR4
  • Surface expression of CCR4 was evaluated by FACS analysis of CD3 + , CD4 + , and CD8 + T lymphocytes. (nih.gov)
  • expression
  • In agreement with the differential chemokine receptor expression, Th1s and Th2s selectively migrate in response to the corresponding chemokines. (nih.gov)
  • high
  • The receptor for MCP-1 through 4 (CCR2) was expressed at high levels in both Th1s and Th2s, with somewhat higher levels for Th1s and considerable variation among different cell preparations. (nih.gov)
  • involve
  • Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. (google.ca)