Loading...
  • Inflammation
  • Inflammation is driven by excessive transmigration (diapedesis) of leukocytes from the blood to the tissue across the endothelial cell monolayer that lines blood vessels. (nih.gov)
  • To determine the role of the murine interleukin-8 receptor homologue (mIL-8Rh, neutrophil chemokine CXC receptor 2) in leukocyte migration using intravital microscopy in a standardized model of eye inflammation, endotoxin-induced uveitis (EIU). (arvojournals.org)
  • Although IL-8 has previously been implicated in cell adhesion, video imaging in vivo demonstrated that deletion of the IL-8 receptor homologue had minimal effect on rolling or arrest in this model of inflammation. (arvojournals.org)
  • molecular mechanisms
  • Whereas several proteins are known to promote ICAM-1 function, the molecular mechanisms that limit ICAM-1-mediated adhesion to prevent excessive leukocyte transmigration remain unknown. (nih.gov)
  • The Keystone meeting on 'Molecular Mechanisms of Leukocyte Trafficking' will be a comprehensive gathering of the world's foremost scientists working in a cutting-edge basic science area with important ramifications for human disease. (keystonesymposia.org)
  • This meeting is a reprise of a highly successful joint meeting on "Molecular Mechanisms of Leukocyte Trafficking" and "Endothelium," held in March 1998. (keystonesymposia.org)
  • recognition
  • These contacts took place in the absence of T cell receptor recognition and were stabilized independently of signaling or the cytoskeleton. (sciencemag.org)
  • surface
  • We also observed the loss of surface type III receptors for the Fc region of IgG (FcγRIII) (CD16). (jimmunol.org)
  • This detection is achieved by surface-bound T cell receptors (TCRs), binding to peptide-loaded major histocompatibility complexes (pMHCs). (sciencemag.org)