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  • PMID
  • The LDL-receptor class A domain contains 6 disulphide-bound cysteines [ PMID: 7548065 ] and a highly conserved cluster of negatively charged amino acids, of which many are clustered on one face of the module [ PMID: 7603991 ]. (ebi.ac.uk)
  • In LDL-receptors the class A domains form the binding site for LDL [ PMID: 6091915 ] and calcium. (ebi.ac.uk)
  • PCSK9
  • Praluent inhibits the binding of PCSK9 (proprotein convertase subtilisin/kexin type 9) to the LDL receptor and thereby increases the number of available LDL receptors on the surface of liver cells, which lowers LDL-C levels in the blood. (thefreedictionary.com)
  • The team notes that trials specifically investigating how PCSK9 inhibitors affect cardiovascular outcomes have yet to be completed, so data for these drugs to date were assessed separately and compared with data for therapies that increase LDL receptor expression. (thefreedictionary.com)
  • LRP5
  • We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus. (biologists.org)
  • intracellular
  • The interaction of Wnt proteins with their receptors on the cell surface is the first step in transducing the extracellular signal into intracellular responses. (biologists.org)
  • Molecular
  • Twelve patients (3 male and 9 female, age 10 to 35 years) with molecular diagnosis of HFH in whom LDL apheresis was regularly performed once every 2 weeks were enrolled in this study. (ahajournals.org)
  • Reduction
  • Conclusions- The present study reveals that HDL cholesterol reduction after high-dose atorvastatin is an early and transient event in HFH patients which magnitude depends on the presence of a residual LDL-R activity. (ahajournals.org)
  • pattern
  • Pattern recognition receptors (PRRs), including members of the Toll-like receptor (TLR) family, play an important role in innate immunity, binding microorganism-derived molecules, and initiating proinflammatory cell signaling ( 1 , 3 , 4 ). (pnas.org)
  • domain
  • It consists of a FIMAC domain (Factor I/MAC proteins C6/C7), a scavenger receptor-like domain, 2 copies of LDLRA and a C-terminal serine protease domain. (ebi.ac.uk)