Receptors lack signaling. Medical search. Frequent questions

Estrogen receptor β (ERβ) is expressed in cortical neurons, and ERβ knock-out mice display impaired performance in cortically mediated processes, suggesting that signaling via this receptor has profound effects on cortical neuron function. (jneurosci.org)
Although all three TGFbeta isoforms and their receptors are present in ocular tissues, lack of TGFbeta2, but not TGFbeta1 or TGFbeta3, perturbs embryonic morphogenesis of the eyes in mice. (nih.gov)
A recent study conducted in mice shows that blocking the receptor for the proinflammatory protein IL-1 using the FDA-approved rheumatoid arthritis drug Anakinra may attenuate the deficits in the functioning of hematopoietic stem cells due to aging. (medicalnewstoday.com)
Here, we produced mice that lacked CB-1 in hepatocytes or stellate cells to determine if CB-1 signaling contributes to the development of NAFLD or liver fibrosis. (jci.org)
To assess requirements for MHCI in the CNS, mice lacking expression of specific MHCI genes were examined. (visionsciences.org)
We generated mutant mice lacking PirB function and discovered that OD plasticity is also enhanced (Syken et al. (visionsciences.org)
Ongoing studies use mice lacking components of the BMP signaling pathway to investigate the role of BMP signaling in iron homeostasis and the innate immune system. (massgeneral.org)
They found that mice whose B cells lacked the receptor for INF-γ had significantly diminished numbers of flu-specific BRMs after influenza virus infection. (eurekalert.org)
The researchers found that mice whose B cells lacked STAT1 also failed to accumulate flu-specific BRMs after influenza infection. (eurekalert.org)
Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell failure, suggesting that insulin signaling is required to maintain an adequate beta cell mass. (nih.gov)
The proposed fellow intends to tackle this problem using a multidisciplinary approach including conditional mouse mutant mice lacking either specific FLRT or Unc5 proteins, cell based functional assays using neurons derived from mutant mice, and molecular and biochemical assays to identify signalling pathways activated by FLRTs. (europa.eu)
In this study, we utilized mice lacking a critical regulator of necroptosis, receptor interacting protein 3 (RIP3) kinase, to characterize the role of RIP3 in normal tissue toxicity after irradiation. (bioone.org)
Katherine D. Castle , Andrea R. Daniel , Everett J. Moding , Lixia Luo , Chang-Lung Lee , and David G. Kirsch "Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome," Radiation Research 189(6), 627-633, (10 April 2018). (bioone.org)

Fig. 1: Photochemistry of light-oxygen-voltage receptors and sequences of proteins under study. (nature.com)
Signal transduction between MyD88 and TRAF6 is known to involve the serine-threonine kinase IL-1 receptor-associated kinase 1 (IRAK-1) and two homologous proteins, IRAK-2 (ref. 12) and IRAK-M. However, the physiological functions of the IRAK molecules remain unclear, and gene-targeting studies have shown that IRAK-1 is only partially required for IL-1R and TLR signalling. (elsevierpure.com)
Mutants of GPR18, designed to constitutively activate receptors, did not tonically inhibit calcium currents, indicating a lack of GPR18 activation or coupling to endogenous G proteins. (unboundmedicine.com)
P2Y12 receptor (P2YR) is a G-coupled7-membrane-spanning proteins. (researchsquare.com)
The EDNRB gene provides instructions for making a protein called endothelin receptor type B. When this protein interacts with other proteins called endothelins, it transmits information from outside the cell to inside the cell, signaling for many important cellular processes. (medlineplus.gov)
Thus, FLRT proteins have the potential to engage in bi-directional signaling ('forward' via Unc5 receptors and 'reverse' via their own intracellular domain), an original and innovative concept which Dr. Klein previously pioneered in the ephrin/Eph field. (europa.eu)
We are studying this signalling system both from the outside (cytokine:receptor interactions) and the inside (JAK and proteins that regulate JAK function) of the cell. (edu.au)
Researchers previously have demonstrated that CD151 can activate extracellular signal-related proteins as well as the intercellular signaling cascade Akt/PKB, which promotes nontumor mammary cell replication. (asbmb.org)
After 1 or 7 days, changes in synaptic proteins, biogenic neurotransmitters and their receptors were evaluated because synaptic disruption and imbalances in dopamine (DA) and serotonin (5-HT) are known to be associated with depression, lack of coordination and short-term memory. (cdc.gov)
Acute exposure to CE altered several axonal and synaptic proteins in discrete brain areas, indicative of aberrant neurotransmitter signaling. (cdc.gov)

Activation of ERβ by WAY-200070 also resulted in the phosphorylation of p21-activated kinase (PAK) and extracellular signal-regulated kinase 1/2 (ERK1/2) in cultured cortical neurons, suggesting a mechanism for the regulation of the actin cytoskeleton. (jneurosci.org)
Signaling via ERβ also resulted in activation of a PAK/ERK1/2 (extracellular signal-regulated kinase 1/2) signaling pathway. (jneurosci.org)
Neurotrophins bind two classes of receptors, the receptor tyrosine kinase family of Trk (A, B, and C) receptors and the p75 neurotrophin receptor (NTR). (jneurosci.org)
Upon trypsin activation, all constructs stimulated MAP kinase signaling, but only the wt-rPAR 2 and rPAR 2 -Ala 39-42 triggered calcium signaling. (aspetjournals.org)
Furthermore, the TL-derived synthetic peptide SLAAAA-NH 2 failed to cause PAR 2 -mediated calcium signaling but did activate MAP kinase, whereas SLIGRL-NH 2 triggered both calcium and MAP kinase signaling by all receptors. (aspetjournals.org)
The peptides AAIGRL-NH 2 and LSIGRL-NH 2 triggered neither calcium nor MAP kinase signals. (aspetjournals.org)
Upon TGF binding to the respective TGF receptor, Smads2/3 are phosphorylated by the receptor kinase at the C-terminus, form a complex with Smad4 and translocate to the nucleus for activation of TGFbeta gene targets. (nih.gov)
Moreover, mitogen-activated protein kinase, c-Jun N-terminal kinase, and p38 modulate Smad signals directly via Smad linker phosphorylation or indirectly via pathway crosstalk. (nih.gov)
The adenylate cyclase/cyclic AMP/protein kinase A (PKA) module is a central component of such biochemical signaling. (harvard.edu)
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. (edu.au)
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. (lu.se)

The β chain is involved in signal transduction and formation of high affinity receptor complex together with α chain. (wikipedia.org)
We prepared mouse embryonic fibroblast (MEF) cells to examine effects of LP B3 deletion on S1P-induced signal transduction pathways. (elsevierpure.com)
The Bloch Laboratory at Massachusetts General Hospital investigates the role of the bone morphogenetic protein signal transduction pathway in a broad spectrum of human diseases, including iron overload syndromes, anemia, inflammation, Sjogren's syndrome, non-alcohol related fatty liver disease, calciphylaxis and atherosclerosis. (massgeneral.org)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

Intracellular signalling mechanisms mediated by TIRs are similar, with MyD88 (refs 5-8) and TRAF6 (refs 9, 10) having critical roles. (elsevierpure.com)
In mammals, the family of Wnt ligands consists of 19 members, which trigger multiple intracellular signaling cascades and orchestrate complex, context-dependent responses. (nature.com)
To identify novel effectors downstream of these receptors, their intracellular domains were used as bait to screen yeast two-hybrid cDNA libraries. (figshare.com)

we are studying the Thrombopoietin receptor, which is important in regulating blood development, and we are trying to develop new strategies for targeting the dysregulated Thrombopoietin signalling that can drive myeloproliferative disease. (edu.au)
However, because the thrombopoietin receptor is the only growth factor receptor in hematopoietic stem cells, thrombocytosis can occur before erythrocytosis. (msdmanuals.com)

However, the effects of ERβ-mediated signaling on dendritic spines of cortical neurons and the underlying molecular mechanisms are unknown. (jneurosci.org)
Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues in its cytoplasmic domain, where are many regions participating in different cell signalling mechanisms for proliferation, differentiation and survival. (wikipedia.org)
As T1-induced internalization was only marginally greater, the dramatic increase in recycling and cAMP signaling may be due to additional mechanisms. (frontiersin.org)
Thus, the ability of a biochemical signal to spread beyond the spine depends on the molecular properties of the messengers involved, mechanisms of retention and inactivation, and passive constraints imposed by the geometry of the spine and dendrite ( Yasuda and Murakoshi, 2011 ). (frontiersin.org)
However, basic research on the evaluation of FJOA and its specific molecular mechanisms has been lacking for many years. (researchsquare.com)
Although the signalling pathways induced by VEGF have been well-studied, the precise molecular mechanisms remain to be determined, particularly with respect to the relative contribution of the individual receptors. (figshare.com)

Smads2/3 are key signaling molecules downstream of cell surface receptors for TGFbeta or activin. (nih.gov)
Indeed, theoretical and experimental analyses indicate that the diffusive resistance of the spine neck is sufficient to effectively compartmentalize some signaling molecules in a spine for the duration of their activated lifetime. (frontiersin.org)
The special morphology of dendritic spines suggests that they biochemically compartmentalize diffusible signaling cascades by restricting the transfer of molecules between the spine head and dendrite. (frontiersin.org)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
we have a strong focus on understanding molecules that regulate JAK/STAT signaling such as the Suppressors of Cytokine Signalling (SOCS). (edu.au)

However, the effect of rapid signaling through estrogen receptor β (ERβ) in cortical neurons is not known. (jneurosci.org)

Blocking NMDA receptors abolished inward rectification of AMPAR-EPSCs of dorsal horn neurons in nerve-injured rats. (aspetjournals.org)
However, the effect of rapid signaling via ERβ on dendritic spines and the signaling pathways initiated by this receptor in cortical neurons are unknown. (jneurosci.org)
These data suggest that signaling through ERβ results in rapid modification of dendritic spines of cortical neurons, supporting the role of brain-synthesized estrogen as a postsynaptic morphogen. (jneurosci.org)
mRNA for PirB, an innate immune receptor, was found highly expressed in neurons in many regions of mouse CNS. (visionsciences.org)
The prevalence of HSCR is 1:5000, and it is characterized by a complete lack of enteric neurons (aganglionosis) in the distal colon. (helsinki.fi)

The glutamate AMPA receptors (AMPARs) are critically involved in the excitatory synaptic transmission, and blocking AMPARs at the spinal level reverses neuropathic pain. (aspetjournals.org)
The structure of dendritic spines suggests a specialized function in compartmentalizing synaptic signals near active synapses. (frontiersin.org)
Here we describe the application of 2-photon microscopy combined with stimulated emission depletion (STED-2P) to the biophysical study of the relationship between synaptic signals and spine morphology, demonstrating the utility of combining STED-2P with modern optical and electrophysiological techniques. (frontiersin.org)
In addition to biochemical signaling cascades, the excitatory synapses of dendritic spines support electrical signaling via post-synaptic potentials. (frontiersin.org)
Thus, MHCI ligands signaling via PirB receptor may function to "brake" activity- dependent synaptic plasticity. (visionsciences.org)

Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains called Toll/IL-IR/plant R gene homology (TIR) domains. (elsevierpure.com)

To address this inconsistency, this study investigated GPR18 coupling in a native neuronal system with endogenous signaling pathways and effectors. (unboundmedicine.com)
We searched for receptors that could interact with neuronal MHCI and carry out these activity-dependent processes. (visionsciences.org)

Mature polypeptide contains 378 amino acids - 298 amino acids in extracellular domain, 26 in transmembrane domain, 54 in short cytoplasmic tail, plus 22 amino acid long signal peptide, which is cleaved off during translation. (wikipedia.org)
Extracellular domain contains cytokine receptor domain for binding its cognate ligand with conserved cysteine residues, WSXWS motif and 11 potential N-glycosylation sites for oligosaccharides, which are important for ligand binding and signalling. (wikipedia.org)
Extracellular domain contains haematopoietin domains, also known as cytokine receptor modules, which can be found in other cytokine receptors (growth hormone receptor, erythropoietin receptor). (wikipedia.org)

glutamate receptor, ionotropic, NMDA1. (wikigenes.org)

Sphingosine 1-phosphate (S1P) exerts diverse physiological actions by activating its cognate G protein-coupled receptors. (elsevierpure.com)
Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. (frontiersin.org)
The VEE is a heterogeneous compartment containing the Adaptor Protein Phosphotyrosine Interacting with Pleckstrin homology Domain and Leucine Zipper 1 (APPL1) with distinct functions in regulating endosomal Gαs/cAMP signaling and rapid recycling. (frontiersin.org)
Membrane trafficking of G protein-coupled receptors (GPCRs) tightly orchestrates the signaling from this superfamily of signaling receptors. (frontiersin.org)
Most neuromodulators exert their function via G-protein-coupled receptors (GPCRs). (harvard.edu)
Recent studies propose that N-arachidonyl glycine (NAGly), a carboxylic analogue of anandamide, is an endogenous ligand of the Gα(i/o) protein-coupled receptor 18 (GPR18). (unboundmedicine.com)
Other downstream effectors of Gα(i/o)-coupled receptors, G protein-coupled inwardly rectifying potassium channels and adenylate cyclase, were not modulated by GPR18 signaling. (unboundmedicine.com)
Activation of P2Y12 receptor first phosphorylates BAD through the PI3K Akt pathway, and the liquid acidified BAD binds to 14-3-3 protein to separate BAD from BAD Bcl-XL complex, thus releasing free Bcl-XL. (researchsquare.com)
The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
The RET gene provides instructions for producing a protein that is involved in signaling within cells. (medlineplus.gov)
Mutations in the RET gene that cause Hirschsprung disease result in a nonfunctional version of the RET protein that cannot transmit signals within cells. (medlineplus.gov)
Without RET protein signaling, enteric nerves do not develop properly. (medlineplus.gov)
The EDN3 gene provides instructions for a protein called endothelin 3, one of the endothelins that interacts with endothelin receptor type B. Together, endothelin 3 and endothelin receptor type B play an important role in the normal formation of enteric nerves. (medlineplus.gov)
Changes in either the EDNRB gene or the EDN3 gene disrupt the normal functioning of the endothelin receptor type B or the endothelin 3 protein, preventing them from transmitting signals important for the development of enteric nerves. (medlineplus.gov)
It tests negative for the three main targets of hormonal and protein receptor therapies: estrogen receptors, progesterone receptors and an upregulation of HER2 protein. (asbmb.org)
CD151 is a scaffolding protein that interacts with integrin receptors. (asbmb.org)

However, predicting the signaling outcome of different Wnt ligands has remained difficult. (nature.com)

Both chimeric receptors were able to activate these effectors. (figshare.com)

The endocannabinoid system regulates appetite and energy expenditure and inhibitors of cannabinoid receptor 1 (CB-1) induce weight loss with improvement in components of the metabolic syndrome. (jci.org)
In addition, we are examining the effects of blocking BMP receptors, using small molecule inhibitors, on the anemia of inflammation and the development of atherosclerosis. (massgeneral.org)

It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. (biolegend.com)
When a cytokine binds to its cognate receptor on the outside of the cell, it initiates a signalling cascade on the inside of the cell through a family tyrosine kinases known as the JAKs (Janus Kinases). (edu.au)
In addition, the observed dependence of some of these effects on a specific tyrosine residue within VEGFR-2 suggested that the chimeric receptors couple to downstream effectors in a manner analogous to that of the full-length receptors. (figshare.com)

AMPARs lacking GluA2 subunit are permeable to Ca 2+ and their currents show unique inward rectification. (aspetjournals.org)

These observations suggest that neurotrophins regulate filopodial dynamics by depressing the activation of RhoA that occurs through p75 NTR signaling. (jneurosci.org)
1999 ) provided evidence that p75 NTR can regulate axon extension by signaling through the RhoA pathway, such that the unbound state of p75 NTR activates RhoA, whereas neurotrophin binding to p75 NTR terminates this mode of RhoA activation. (jneurosci.org)
Interactions then mediate conformational changes and subsequent receptor activation. (wikipedia.org)
Activation of Wnt signalling because of lack of ability to degrade -catenin is situated in >85% of colorectal malignancies. (healthdisparitiesks.org)
Retrovirus-mediated rescue of the LP B3 receptor in LP B3 -null MEF cells restored S1P-dependent PLC activation and adenylyl cyclase inhibition. (elsevierpure.com)
One major challenge for understanding neuromodulator action is the lack of dynamic readouts of the biochemical signals produced by GPCR activation. (harvard.edu)
Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation. (rndsystems.com)
CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. (biolegend.com)
This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. (cancerindex.org)
The authors found that while DMH-CBD also inhibits TNF production and activation of NF-kB, this reduction was not related to the Toll-like Receptor 2 pathway, unlike CBD. (news-medical.net)
Instead, DMH-CBD reduced the Nf-kB activity via the activation of A 2A receptors. (news-medical.net)
In the presence of a A 2A receptor antagonist, the effects of DMH-CBD on NF-kB activation could be completely reversed. (news-medical.net)
The mechanism of CBD is related to its effects on cell viability, while the effects of DMH-CBD are via the activation of A 2A receptors. (news-medical.net)

The signaling pathways activated by neurotrophins can regulate cytoskeletal dynamics, which in turn determine growth cone behaviors (Gallo and Letourneau, 1998 , 2000 ). (jneurosci.org)

Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)
Sex steroid receptors (SSRs), which are involved in BC etiology and progression, promote BCSC proliferation, dedifferentiation and migration. (wjgnet.com)
Development of the ENS is a complex process, and many signalling pathways are required for a properly functioning ENS, especially GDNF/Gfrα1/RET signalling controlling survival, proliferation, migration, and differentiation of ENCCs. (helsinki.fi)

Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)
This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. (cancerindex.org)
A gene expression array showed significantly increased expression of CCR3, a receptor of eotaxin-3, in PC-3. (cancerindex.org)

This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). (cancerindex.org)

β chain is crucial for enhancement of binding affinity to the ligand and transduces signal of the activated receptor complex. (wikipedia.org)
Formation of high affinity receptor complex includes specific interactions between both subunits and ligand. (wikipedia.org)
We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat proteinase-activated receptor 2 (rPAR 2 ) and the corresponding soluble TL-derived agonist peptides to trigger agonist-biased signaling. (aspetjournals.org)
After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. (joplink.net)
Analysis of phosphorylation-dependent interactions downstream of VEGFR-1 in mammalian cells, which is generally hindered by the lack of ligand-induced receptor phosphorylation, was enabled by the development of chimeric receptors. (figshare.com)
The chimeric receptors were significantly activated in response to ligand, thereby enabling studies of this signalling with the putative effectors PKB/Akt, PLC and ERK1.2. (figshare.com)

While CB-1 blockage in brain is responsible for weight loss, many of the metabolic benefits associated with CB-1 blockade have been attributed to inhibition of CB-1 signaling in the periphery. (jci.org)

For example, previous studies show that cannabinoids can work as anti-inflammatory drugs, they can suppress the signaling of T cell receptors, induce apoptosis, lower the levels of pro-inflammatory cytokines, and act on macrophages. (news-medical.net)

Increased prevalence of spinal GluA2-lacking AMPARs in neuropathic pain is mediated by NMDA receptors and subsequent stimulation of calpain and calcineurin signaling. (aspetjournals.org)

One key mechanism dictating the signal activity of GPCRs is membrane trafficking. (frontiersin.org)
The receptor then returns to the cell membrane surface. (joplink.net)
RET is a receptor on the cell membrane that mediates the effects in GDNF/Gfrα1/RET signaling pathway. (helsinki.fi)

It has long been hypothesized that the morphology of dendritic spines might play a role in regulating the spread of electrical signals. (frontiersin.org)

Two main VEGF receptors are expressed in endothelial cells: VEGFR-1 and VEGFR-2. (figshare.com)

The lack of trypsin-triggered β-arrestin interactions correlated with impaired trypsin-activated TL-mutant receptor internalization. (aspetjournals.org)

Our study suggests that nerve injury increases GluA2 internalization and the prevalence of GluA2-lacking AMPARs in the spinal dorsal horn to maintain chronic neuropathic pain. (aspetjournals.org)
The data indicate that the proteolytically revealed TL sequence(s) and the mode of its presentation to the receptor (tethered versus soluble) can confer biased signaling by PAR 2 , its arrestin recruitment, and its internalization. (aspetjournals.org)
After binding its hormone FSH, FSHR undergoes internalization to very early endosomes (VEEs) for its acute signaling and sorting to a rapid recycling pathway. (frontiersin.org)
Given the critical nature of receptor internalization and endosomal signaling for FSHR activity, we assessed whether these compounds exhibit differential abilities to alter receptor endosomal trafficking and signaling within the VEE. (frontiersin.org)
All compounds exhibited a similar requirement for receptor internalization to increase cAMP and proportion of FSHR endosomes with active Gαs, suggesting regulation of cAMP signaling induced by T1 may be altered. (frontiersin.org)

Simple Western™ analysis of lysates (0.75 mg/mL) from Mouse Brain cells using AMPA Receptor 4 (GluA 4) (D41A11) XP ® Rabbit mAb #8070. (cellsignal.com)
Confocal immunofluorescent analysis of rat retina using AMPA Receptor (GluA 4) (D41A11) XP ® Rabbit mAb (green). (cellsignal.com)
Western blot analysis of extracts from mouse brain, NIH/3T3 cells, rat brain, and C6 cells using AMPA Receptor 4 (GluA 4) (D41A11) XP ® Rabbit mAb. (cellsignal.com)

The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. (wikipedia.org)
The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development. (wikipedia.org)
Proper expression and trafficking of receptor were confirmed by the "rim-like" fluorescence of fluorescently tagged receptor and the positive staining of external hemagglutinin-tagged GPR18-expressing cells. (unboundmedicine.com)
The researchers asked whether the requirement for IFN-γ signaling in lung-BRM development was intrinsic to B cells, meaning the interferon was producing effects inside the B cells. (eurekalert.org)
Inside B cells, the transcription factor STAT1 is known to be required for optimal INF-γ signaling. (eurekalert.org)
In mechanistic details, the researchers found that intrinsic IFN-γ-STAT1 signaling in B cells in the germinal center of lung-draining lymph nodes promoted expression of the T-bet transcription factor, and T-bet was necessary for differentiation into pre-memory B cells that express the surface marker CXCR3. (eurekalert.org)
Foxo1 and Pdx1 exhibit mutually exclusive patterns of nuclear localization in beta cells, and constitutive nuclear expression of a mutant Foxo1 is associated with lack of Pdx1 expression. (nih.gov)
There are two main types of Hirschsprung disease, known as short-segment disease and long-segment disease, which are defined by the region of the intestine lacking nerve cells. (medlineplus.gov)
Multicolor flow cytometric analysis of Leptin Receptor (CD295) on human mononuclear cells. (bdbiosciences.com)
The Center for Nuclear Receptors and Cell Signaling at the University of Houston has developed a new way to detect very rare and highly heterogeneous circulating tumor cells with high specificity and sensitivity. (uh.edu)
Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling, invented the UniPro which finds rare circulating tumor cells. (uh.edu)
The research team headed by Li and Li generated cells lacking CD151 to interrogate its function. (asbmb.org)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk. (lu.se)
Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4 + /CD57 - cells normally do so. (lu.se)

This module is regulated by several behaviorally important neuromodulator receptors. (harvard.edu)

While canonical, β-catenin-dependent Wnt signaling is well studied and has been linked to many forms of cancer, much less is known about the role of non-canonical, β-catenin-independent Wnt signaling. (nature.com)
Non-canonical, β-catenin-independent Wnt signaling is proposed to have a multifunctional role in tumorigenesis, being either tumor supportive or suppressive depending on tumorstage and tumortype 9 . (nature.com)

The JAK/STAT pathway is important in many biological processes, including growth and development, hematopoiesis, immunity and inflammation, and aberrant JAK/STAT signalling can lead to diseases such as chronic inflammatory disease and cancer. (edu.au)

In turn, receptor signaling is known to drive or regulate GPCR trafficking. (frontiersin.org)

APPL1 plays a central role for GPCRs targeted to the VEE, and indeed, loss of APPL1 inhibited FSH-induced recycling and increased endosomal cAMP signaling. (frontiersin.org)

CTCs, like the tumors they are originally detached from, lack unique and well-defined universal biomarkers highlighting the challenges of detection specificity," reports Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling. (uh.edu)
Zhang's research team includes Xinping Fu and Lihua Tao, both from the Department of Biology and Biochemistry and Center for Nuclear Receptor and Cell Signaling at UH. (uh.edu)

Signaling without glutamine appears intrinsic to light-oxygen-voltage receptors, which pertains to biotechnological applications and suggests evolutionary descendance from redox-active flavoproteins. (nature.com)

Another splicing variant lacks both transmembrane and cytoplasmic domains. (wikipedia.org)

Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)

Wnt signaling pathways control a wide range of processes during embryonic development and tissue homeostasis. (nature.com)

Our results suggest that RIP3-mediated signaling is not a critical driver of acute radiation syndrome. (bioone.org)

Likely via a radical-pair mechanism 12 , T 1 reacts within microseconds to the signaling state, characterized by a covalent thioadduct between a highly conserved cysteine residue in the LOV photosensor and the C4a atom of the flavin isoalloxazine ring system. (nature.com)

Axin1 and GSK3β are recruited to the receptor complex upon Wnt stimulation and this leads to a breakdown of the destruction complex and β-catenin stabilization. (nature.com)

These results implicate ERβ signaling in controlling dendritic spine morphology, in part via a PAK/ERK1/2-dependent pathway, and provide mechanistic insight into the rapid cellular effects of estrogen on brain function. (jneurosci.org)
These results indicate a nonessential role for LP B3 in normal development of mouse but show nonredundant cellular signaling mediated by a single type of S1P receptor. (elsevierpure.com)

While T1-induced FSHR recycling was APPL1-dependent, its elevated cAMP signaling was only partially increased following APPL1 knockdown. (frontiersin.org)
However, a lack of suitable postnatal HSCR mouse models has partially hindered the progress of pinpointing the exact order of these events. (helsinki.fi)

However, in contrast to clear confirmation of the compartmentalization of certain biochemical signals, whether spine morphology regulates synaptically evoked electrical activity has been controversial ( Tsay and Yuste, 2004 ). (frontiersin.org)

suggesting that ERβ signaling may play a role in these cortically mediated behaviors. (jneurosci.org)
We investigated the role of the p75 neurotrophin receptor (p75 NTR ) in mediating neurotrophin-induced increases in filopodial length. (jneurosci.org)
In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. (wikipedia.org)
Combined, these studies do not support a direct role for hepatocyte or stellate cell CB-1 signaling in the development of NAFLD or liver fibrosis. (jci.org)

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes3

Mice13

Proteins10

Kinase11

Transduction4

Intracellular3

Thrombopoietin Receptor2

Mechanisms6

Molecules5

Estrogen receptor1

Neurons5

Synaptic5

Pathogen-associat1

Neuronal2

Extracellular3

Glutamate1

Protein17

Ligands1

Activate1

Inhibitors2

Tyrosine3

Subunit1

Activation13

Pathways activated1

Proliferation3

Gene4

Binds1

Ligand6

Inhibition1

Induce1

NMDA1

Membrane3

Dendritic spines1

Endothelial Cells1

Interactions1

Internalization5

AMPA3

Cells16

Neuromodulator1

Canonical2

Aberrant1

Regulate1

GPCRs1

Biochemistry2

Intrinsic1

Cytoplasmic domains1

Cytokines1

Processes1

Acute1

Mechanism1

Stimulation1

Cellular2

Partially2

Biochemical signals1

Role4