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  • gene
  • Using porcine transcriptome data, both the novel inhibitory gene and the LILR were highly expressed in peripheral blood, while the single KIR gene, KIR2DL1 , was either very poorly expressed or not at all. (springer.com)
  • The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). (genecards.org)
  • GO annotations related to this gene include transmembrane signaling receptor activity . (genecards.org)
  • Here, we analyzed for the first time KIR gene polymorphisms for 167 OA individuals, including those from four smallest OA subgroups (Che Wong, Orang Kanaq, Lanoh and Kensiu) using polymerase chain reaction-sequence specific primer (PCR-SSP) analyses. (nih.gov)
  • Unlike T cells, NK cell receptors are germline encoded, and therefore do not require somatic gene rearrangements. (wikipedia.org)
  • Single substitutions, insertions, or deletions in the genetic material that encodes KIR receptors changes the site of termination for the gene, causing the cytoplasmic tail to be long or short, depending on the site of the stop codon. (wikipedia.org)
  • The CB1 receptor is encoded by the gene CNR1, located on human chromosome 6. (wikipedia.org)
  • polymorphic
  • These include the killer-cell Ig-like receptors (KIR) and the leukocyte Ig-like receptors (LILR) which can be polymorphic and vary greatly in number between species. (springer.com)
  • In contrast, mice ( Mus musculus ) have a highly expanded and polymorphic repertoire of KLRA genes, but possess only two KIR -like genes outside the LRC and which are thought to have alternative functions (Bryceson et al. (springer.com)
  • The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). (genecards.org)
  • peripheral blood NK cells
  • To evaluate how Notch influences terminal differentiation, cord blood derived NK cells or sorted KIR- peripheral blood NK cells were cultured with IL-15 for 7 days in the presence or absence of gamma-secretase inhibitor, known to inhibit Notch signaling. (jimmunol.org)
  • In addition, they express CD16 and KIRs upon IL-2 activation, and therefore display a phenotype similar to peripheral blood NK cells. (jimmunol.org)
  • We present in this study a comprehensive analysis of human NK cells in secondary lymphoid organs, emphasizing their differences from peripheral blood NK cells in inhibitory and activating receptors as well as cytolytic activity. (jimmunol.org)
  • Distribution of KIR
  • Distribution of KIR haplotype A and B frequencies among global populations.All KIR haplotypes frequencies used are listed in S5 Table. (nih.gov)
  • murine
  • Subsequent work has characterized a diffuse TREM/TREM-like cluster of receptors that occupies approximately 150 Kbp of murine chromosome 17. (cancer.gov)
  • Genetic
  • In contrast, the two Senoi subgroups, Che Wong and Semai are displaced toward Southeast Asian and African populations in the PCA scatter plot, respectively.Orang Kanaq tradition that strictly prohibits intermarriage with outsiders seems to have posed a serious threat to their survival.This present survey is a demonstration of the value of KIR polymorphisms in elucidating genetic relationships among human populations. (nih.gov)
  • This present survey is a demonstration of the value of KIR polymorphisms in elucidating genetic relationships among human populations. (nih.gov)
  • tumor
  • Because natural killer cells target virally infected host cells and tumor cells, inhibitory KIR receptors are important in facilitating self-tolerance. (wikipedia.org)
  • Blood 2009 http://bloodjournal.hematologylibrary.org/content/114/13/2667.full.pdf Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells Efficacy Study of Anti-KIR Monoclonal Antibody as Maintenance Treatment in Acute Myeloid Leukemia (EFFIKIR) (EFFIKIR) Innate Pharma Leukemia Candidate Lirilumab Fails Phase II Trial. (wikipedia.org)
  • A2AR - The Adenosine A2A receptor is regarded as an important checkpoint in cancer therapy because adenosine in the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively high concentrations of adenosine. (wikipedia.org)
  • antigen receptor
  • Chimeric Antigen Receptor (CAR) engineered T-lymphocytes are currently the buzz in Immuno-Oncology, having shown that infusion of those engineered cells can achieve remissions in some patients with acute and chronic leukemia. (wikipedia.org)