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  • hippocampus
  • We have investigated the expression and activity of MMP-7 and TIMP-1 in the hippocampus following kainic acid-induced injury, the relationship of this enzyme-inhibitor system to proNGF processing, and the consequences for p75 NTR -mediated apoptosis in vitro and in vivo . (jneurosci.org)
  • decreased seizure
  • After sparteine pretreatment (13mg/kg, administered 30min before the convulsive drug), the animals administered pentylenetetrazole and pilocarpine exhibited reduced mortality rates compared with the corresponding control groups, while the animals administered kainic acid exhibited a delayed onset of convulsive behavior and decreased seizure duration compared with the corresponding control group. (deepdyve.com)
  • subtypes
  • But because serotonin can increase or decrease cortical pyramidal neuron activity depending on its concentration and which receptor subtypes are activated, more research is needed to more fully elucidate how aggressive behaviors are controlled. (jneurosci.org)
  • seizures
  • Publications] Yoshida K: 'Central type benzodiazepine receptor binding image in kainic-acid induced seizures. (nii.ac.jp)
  • Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain? (springer.com)
  • In this study, we demonstrate that, following kainic acid-induced seizures, the proNGF processing enzyme matrix metalloproteinase 7 (MMP-7) and its inhibitor TIMP-1 (tissue inhibitor of matrix metalloproteinase 1) are regulated in a manner that prevents proneurotrophin cleavage and leads to increased proNGF in the extracellular milieu. (jneurosci.org)
  • Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. (mdpi.com)
  • Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid poisoning and unusual behaviors in animal subjects, notably conspecific aggression. (mdpi.com)
  • It is also evident that domoic acid can trigger a separate process of epileptogeneis, which, over a latent "silent" period of weeks to months, causes a disease state of progressive recurrent seizures and behavioral abnormalities [ 8 , 9 , 10 , 11 ]. (mdpi.com)
  • 1998
  • The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic epileptic syndrome in California sea lions through investigation of a series of domoic acid poisoning cases between 1998 and 2006. (mdpi.com)
  • ligand
  • Therefore, A collaboration mechanism between the ET_A and the ET_B receptorS may function in the recognition of ET-1, a typical 'bivalent' ligand. (nii.ac.jp)
  • However, the precursor of NGF, proNGF, is a potent apoptotic ligand for the p75 neurotrophin receptor (p75 NTR )-sortilin complex. (jneurosci.org)
  • We show that transition to the active state involves a 'corkscrew' motion of the receptor assembly, driven by closure of the ligand-binding domain. (nih.gov)
  • 1980
  • Ben-Ari, Y., Tremblay, E., and Ottersen, 0.P., 1980, Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy, Neuroscience 5: 515. (springer.com)
  • rats
  • The mode of seizure propagation was studied using generalized seizure models induced by a microinjection of kainic acid (KA) into unilateral mesencephalic reticular formation (MRF) or pontine reticular formation (PRF) of unrestrained cats or rats. (nii.ac.jp)
  • proteins
  • 2) ET_A receptor proteins were observed in the area posterior, the caudal solitary tract nucleus and dorsal nucleus of the vagus in rat brainstem, whereas ET_A mRNA was localized to only area posterior. (nii.ac.jp)
  • On the other hand, the distribution of ET_B receptor proteins was similar to that of ET_B mRNA, and the ET_B receptors were expressed in the glia cells. (nii.ac.jp)
  • amino acids
  • Moreover, brain structures which are considered anatomical substrata for learning and memory may be particularly vulnerable to the neurotoxic actions of these excitatory amino acids, especially in the elderly who are also the segment of the population most susceptible to impairments of mnemonic function. (springer.com)
  • This paper is a review of data concerning the role of excitatory amino acids in the processes of learning and memory and in the pathogenesis and treatment of disorders thereof. (springer.com)
  • Banay-Schwartz M, Lajtha A, Palkovits M (1989) Changes with ageing in the levels of amino acids in rat CNS structural elements. (springer.com)
  • I. Glutamate and related amino acids. (springer.com)
  • regulate
  • microglia expresse various P2X and P2Y receptors, nucleotide receptors, which regulate not only chemotaxis but also phagocytosis [ 8 , 12 ]. (hindawi.com)
  • Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. (nih.gov)
  • postsynaptic
  • these calcium changes in turn produce low or high levels of ATP release and hydrolysis, differential activation of A 1 and A 2A adenosine receptors, and postsynaptic depression or potentiation, respectively. (jneurosci.org)
  • Mouse neuromuscular junction showing perisynaptic Schwann cells (red), the presynaptic terminal (green), and postsynaptic nACh receptors (blue). (jneurosci.org)
  • Excitotoxicity
  • Publications] Fujita T,: 'Electroclinical and pathological studies after parenteral administration of domoic acid i freely moving non-anesthetized cats:An animal model of excitotoxicity' Journal of Epilepsy. (nii.ac.jp)
  • Maturation
  • This concept report focuses on those essential characteristics of domoic acid poisoning that lead to epileptic disease drawing on case studies in humans and sea lions and a rat model to elucidate the structural basis specific to domoic acid epileptic maturation. (mdpi.com)
  • Nucleotide
  • Toll-like receptor (TLR)-and in the cytoplasm [e.g. nucleotide-binding oligomerization domain (Nod)-like receptors] of cells of the innate immune system, primarily macrophages and dendritic cells. (biologists.org)
  • Strains
  • Kainic acid receptor sites in the cerebellum of nervous, purkinje cell degeneration, reeler, staggerer and weaver mouse mutant strains. (jax.org)
  • Our results obtained so far suggested a possibility of the 3rd receptor for SSPE strains different from CD150 (SLAM) and CD46. (nii.ac.jp)
  • Autoradiography
  • We investigated the distribution of endothelin (ET) receptors and their functions by using our imazing Analyzer system, including quantitative receptor autoradiography, in situ hybridization and Immunohistochemistry. (nii.ac.jp)
  • functional
  • The results of this study indicate that coexpression of NR1, NR3A, and NR3B subunits in HEK 293 cells results in glycineactivated receptors with novel functional and pharmacological properties. (aspetjournals.org)
  • inhibition
  • It is well documented that opioids are able to profoundly depress and even eliminate the HVR mainly via activating central μ-opioid receptors in both animals and humans, 11-14 but the central site(s) responsible for this inhibition remains unknown. (asahq.org)
  • Ethanol inhibition was enhanced in receptors expressing the NR1(L819A) mutant, whereas those containing NR1(F639A) or NR1(M813A) showed no change relative to the wild-type NR1. (aspetjournals.org)
  • cerebellar
  • To provoke the release of [ 3 H]aspartic acid from cerebellar slices, 10 µM KA (Potashner and Gerard, 1983) or at least 500 µM KA (Ferkany and Coyle, 1983) are necessary. (springer.com)
  • membranes
  • Effects of thiol-reagents on [ 3 H]α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to rat telencephalic membranes. (springer.com)
  • purkinje
  • Kainic acid receptor sites in the cerebellum of nervous, purkinje cell" by C A. Griesser, M Cuenod et al. (jax.org)
  • 1) co-localization of both receptors in the circumventricular organs, and anterior and posterior lobes of the pituitary gland, etc., 2) only ET_A receptor in the Rathke pouch of pituitary gland, etc., 3) only ET_B receptor in the external plexiform layer of olfactory bulb and the Purkinje cell layer. (nii.ac.jp)
  • convulsive
  • The animals of the control groups, which received intraperitoneal pentylenetetrazole (90mg/kg), kainic acid (9mg/kg) or pilocarpine (370mg/kg), exhibited convulsive behavior and epileptiform activity. (deepdyve.com)