Receptors ige. Medical search. Frequent questions

Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. (wikidata.org)
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. (wikidata.org)
Purified rat serosal mast cells were sensitized with mouse immunoglobulin E (IgE) anti-2,4-dinitrophenyl antibody, partially depleted of phosphate, labeled with [ 32 P]orthophosphate, and stimulated with dinitrophenylated bovine serum albumin or control protein. (wustl.edu)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
He stayed at Sheffield and undertook research into the molecular basis of Immunoglobulin E (IgE) receptor interactions with a focus on therapeutic intervention in allergy graduating with a PhD in 1997. (nottingham.ac.uk)
The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. (thermofisher.com)
Risk factors for asthma include a family history of allergic disease, the presence of allergen-specific immunoglobulin E (IgE), viral respiratory illnesses , exposure to aeroallergens , cigarette smoke, obesity , and lower socioeconomic status. (medscape.com)
People with X-linked hyper IgM syndrome have low levels of three other classes of antibodies: immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin E (IgE). (medlineplus.gov)
Malveaux also uncovered basic information about the control of cell receptors for immunoglobulin E (IgE)-the molecule involved in allergic responses. (encyclopedia.com)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
Immunoglobulin E (IgE) are antibodies that are produced by the immune system. (news-medical.net)
That's a good point, and I think when we talk a little bit later about potential treatments of severe asthma and looking at drugs like omalizumab, dendritic cells express high-affinity IgE [immunoglobulin E] receptors in IgE, and it's been shown that when they have a big expression of that, they decrease their interferon gamma production in response to viral infections like rhinovirus. (consultantlive.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)
Candidate models for hazard identification investigate respira- ment of HMW asthma is associated with elevated tory allergic potential in rodents on the basis of serum IgE or immunoglobulin E (IgE) levels, the predominance of Th2 cytokine fingerprinting in skin and skin-draining lymph nodes following dermal application of the chemical (Dearman, Skinner, and Humphreys 2003). (cdc.gov)

Ige Antibody Laboratories manufactures the anti-ige receptor antibody test is low reagents distributed by Genprice. (crossfirebeilstein.com)
The Anti-Ige Receptor Antibody Test Is Low reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (crossfirebeilstein.com)
Description: A sandwich ELISA for quantitative measurement of Rat anti-IgE receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (crossfirebeilstein.com)
The B3B4 antibody is useful for blocking IgE activity in vivo . (biolegend.com)
Description: The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability. (thermofisher.com)
Goat Anti-Mouse IgE-AP antibody for use in ELISA, immunocytochemistry, and western blot assays. (southernbiotech.com)

PMID 19245427 ] Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. (snpedia.com)
PMID 20141544 ] FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (snpedia.com)
Mice demonstrated allergic asthma evidenced by marked increases in airway inflammation, lung eosinophilia, goblet cell metaplasia, epithelial cell thickening, airway hyper-reactivity, Th2 cytokine expression, and serum IgE levels as well as TDI-specific IgG antibodies. (cdc.gov)

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. (thermofisher.com)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)

Molecular cloning of the zeta chain of the T cell antigen receptor. (wikidata.org)
However, phosphorylation of the 33,000 M(r) β component of the IgE receptor was not altered significantly by antigen stimulation. (wustl.edu)
This suggests that the selective increase in phosphorylation of the IgE receptor α component may be part of the physiologic mediator secretion process triggered by antigen. (wustl.edu)
Hempstead, BL, Parker, CW & Kulczycki, A 1983, ' Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells ', Proceedings of the National Academy of Sciences of the United States of America , vol. 80, no. 10 I, pp. 3050-3053. (wustl.edu)
In summary, by hyperimmunization with anti‐IgE mAb we could obtain anti‐Id whose antigen‐binding site is recognized by the mast cell receptor specific to the Fc portion of IgE. (huji.ac.il)
Crosslinking of IgE-bound Fc[epsilon]RI by antigen initiates intracellular signaling, eventually resulting in the release of histamines and other cellular mediators of the allergic response. (igert.org)
CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. (thermofisher.com)
This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. (bvsalud.org)

The presence of anti-IgE receptor (FcεR1α) antibodies in patient serum or plasma has been associated with chronic spontaneous urticaria (CSU), which is a common skin disorder affecting 0.5% to 1.8% of the general population. (epitopediagnostics.com)
However, only after 10 immunizations over a period of about 6 months could we detect antibodies that competed efficiently with the binding of IgE to rat basophilic leukemia (RBL) cells. (huji.ac.il)
F(ab′) 2 and Fab′ fragments were as effective inhibitors of IgE binding as the intact anti‐anti‐Id antibodies. (huji.ac.il)
We raised anti‐anti‐IgE antibodies in an attempt to obtain anti‐Id capable of interacting with the Fcϵ receptor (FcϵR). (huji.ac.il)
Guinea pigs were immunized with purified murine monoclonal antibodies (mAb) that had been found to react with epitopes closely related to the site on the IgE molecule which is recognized by the FcϵR. (huji.ac.il)
When CD40 ligand and its receptor protein are connected, they trigger a series of chemical signals that instruct the B cell to start making IgG, IgA, or IgE antibodies. (medlineplus.gov)
If CD40 ligand does not attach to its receptor on B cells, these cells cannot produce IgG, IgA, or IgE antibodies. (medlineplus.gov)
Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
IgE is the least abundant isotype of all antibodies, but it is capable of triggering the most powerful immune reactions. (antibodies-online.com)
Certain variations of this gene cause the production of IgE antibodies and an elevated level of these antibodies is associated with an allergic response. (news-medical.net)
Additional studies involving passive transfer and the use of transgenic FcErIg knockout mice, which lack IgE and IgG Fc receptors, established the importance of reagenic antibodies. (cdc.gov)
1995). Diisocyanates and acid anhydrides cyanates has a low association with atopy, low prevalence are among the most common low molecular weight (LMW) with specific IgE antibodies and a mixed Th1-Th2 response classes of chemicals responsible for occupational asthma. (cdc.gov)

My early work focused on the mechanisms of IgE receptor regulation and I have led several translational studies in allergic subjects to better understand the role of allergen specific IgE. (hopkinsmedicine.org)
Correlation of vitamin D receptor genotypes, Specific IgE levels and other variables with asthma control in children. (cdc.gov)
Cat Allergy: A Widespread Problem This study was designed to quantify the level of cat allergen in mattress dust and to determine whether a relationship exists with the level of specific IgE to cat. (medscape.com)

ii) the number of IL-13Ralpha1+ bronchial submucosal mast cells in subjects with asthma and normal controls and (iii) the effect of IL-13 priming on HLMC expression of high-affinity IgE receptor (FcepsilonRI), stem cell factor receptor (CD117), histamine release, proliferation, and survival. (nih.gov)
IL-13 priming for 30 min did not increase HLMC histamine release, in the presence or absence of SCF or in response to IgE/anti-IgE activation. (nih.gov)
P=0.003), increased histamine release following IgE/anti-IgE activation by 56% (P=0.03) and increased proliferation by 50% (P=0.003) without affecting cell survival or CD117 expression. (nih.gov)
When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. (thermofisher.com)
MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects. (bvsalud.org)

The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. (wikipedia.org)
Interleukin 13 (IL-13) is an effector cytokine partially sharing the signaling pathways with IL-4 due to the utilization of a common receptor system (IL-4 receptor type II). (wikipedia.org)
Asthma studies have found a relationship between developing the disease and the following genes: cytokine genes, cytokine receptor genes, HLA genes and CD14 gene. (news-medical.net)
His main interests are on the mechanisms of transmembrane signal instigation with a particular focus on G protein-coupled receptors and cytokine receptors. (stanford.edu)

CD23 promoter in B cells, arginase1 enhancer in macrophages ) The binding affinity of IL-4 for IL-4Rα is much higher than IL-13 for the IL-13Rα1, hence IL-4 would out-compete IL-13 for receptor availability within IL4R2 at parity of concentration. (wikipedia.org)
CD23 is a 45 kD protein also known as low affinity IgE Fc receptor, FcεRII, BLAST-2, Ly-42, or B6. (biolegend.com)
CD23 responds to high levels of IgE by downregulating IgE secretion. (biolegend.com)

This ELISA (enzyme-linked immunosorbent assay) kit is intended for the quantitative determination of human anti-human IgE Receptor (FcεR1α) autoantibody levels in human serum or plasma samples. (epitopediagnostics.com)
C38-2 is useful as a standard in a mouse IgE sandwich ELISA. (bdbiosciences.com)

The test may be useful for detecting patients with chronic spontaneous urticaria who have developed autoantibodies (mainly IgG) to the IgE receptor. (epitopediagnostics.com)
Professor Marcus Maurer asks Dr Sherezade Moñino-Romero about her research into soluble IgE receptor and its potential as a marker of treatment response in chronic urticaria. (ga2len-ucare.com)
He has served as the principal investigator and co-investigator for basic and translational studies examining the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis, and chronic urticaria. (hopkinsmedicine.org)
My recent studies focus on the mechanisms underlying chronic urticaria, where we found altered IgE-receptor signaling related to the phenotype of mast cells and basophils. (hopkinsmedicine.org)

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (snpedia.com)

By getting rid of the IgE bound to dendritic cells, that may restore and protect you somewhat from viral infections as an exacerbation factor, and that's what drugs that would reduce IgE high-affinity receptor would do. (consultantlive.com)
Lantero , S et al "Stimulation of eosinophil IgE low-affinity receptor leads to increased adhesion molecule expression and cell migration. (ersjournals.com)
rs2251746 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE ( FCER1A ) on chromosome 1q23. (snpedia.com)

The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions. (thermofisher.com)
It has also been reported in blocking of IgE to Fc epsilon Receptor and degranulation of mast cells. (thermofisher.com)
Fc[epsilon]RI , the high affinity IgE receptor, is the primary receptor on mast cells. (igert.org)
The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (expasy.org)

Healthcare Costs Associated With Asthma Treatments This study compared the cost of treating patients with inhaled corticosteroids or leukotriene receptor antagonists. (medscape.com)

This different distribution of secondary chains accounts for the difference in distribution of completed receptors, with being IL-4RI prevalently expressed in lymphocyte, and IL-4RII prevalently in non-hematopoietic cells. (wikipedia.org)
Consequently, only IL-4, through IL-4R1, is able to modulate the function of lymphocytes inducing Th2 polarisation and B cells IgG1/IgE class switching, while IL-13 is mainly acting on myeloid cells and non-hematopoietic cells, having strong effects on mucus production, smooth muscle contraction, epithelium permeabilisation (e.g. allergic asthma). (wikipedia.org)
The IL-13 receptor, IL-13Ralpha1, is expressed on most leukocytes, except T-cells. (nih.gov)
My research has focused on the IgE receptor activation of human basophils and mast cells. (hopkinsmedicine.org)
Yano, S , Tachibana, H & Yamada, K 2005, ' Flavones suppress the expression of the high-affinity IgE receptor FCεRI in human basophilic KU812 cells ', Journal of Agricultural and Food Chemistry , vol. 53, no. 5, pp. 1812-1817. (elsevierpure.com)
Antigenic stimulation of intact rat mast cells produced a rapid and marked increase in the phosphorylation of the surface-exposed α component of the IgE receptor. (wustl.edu)
Some of the anti‐Id caused RBL degranulation and all of them, like IgE, inhibited the binding of specific anti‐Fc ϵ R mAb to RBL cells. (huji.ac.il)
Although innate immune cells do not respond to specific antigenic epitopes on pathogens, they do produce restricted responses to par- ticular classes of pathogens through pattern-recognition receptors (PRR), such as Toll-like receptors (TLR) (18). (cdc.gov)
They block Fc receptors on macrophages, suppress inducer T and B cells, augment suppressor T cells, and block the complement cascade. (medscape.com)
is expressed on mast and basophil cells and is up-regulated by the presence of IgE. (thermofisher.com)
The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. (thermofisher.com)
CD40 ligand attaches like a key in a lock to its receptor protein, which is located on the surface of immune system cells called B cells. (medlineplus.gov)
Patrick Cutler is currently working on applying this SPT algorithm to localizing and tracking QD-IgE on live cells, working in the laboratory of his main advisor, Prof. Diane Lidke from the Dept. of Pathology, UNM School of Medicine. (igert.org)
SPT of QD-IgE on live cells combined with the quantification of receptor mobility using the maximum likelihood estimator for diffusion will provide significant insights into membrane protein dynamics. (igert.org)
IgE plays an important role in allergy, and leads to excessive activation of mast cells and basophils by binding to their Fc receptors, resulting in an extreme inflammatory response. (antibodies-online.com)
IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. (harvard.edu)
Omalizumab, a humanized mAb that binds to the CH3 domain near the binding site for the high-affinity type-I IgE Fc receptors of human IgE, can neutralize free IgE and inhibit the IgE allergic pathway without sensitizing mast cells and basophils. (medscimonit.com)
Solomon plans to look at a protein on the circulating T cells' surfaces, called the T cell receptor (TCR), that he suspects differs in those with SOID and may explain their symptoms. (primaryimmune.org)
Accordingly, we demonstrate that this particular subset secretes higher amounts of IgM after stimulation with pneumococcal polysaccharides or a toll-like receptor 9 (TLR9) agonist than IgM+CD300a- cells. (bvsalud.org)
Toll-like receptor signaling-deficient cells (TLR4, TLR9, or MyD88 knockout) were used as "silent cells," while regular MSCs were used as control. (bvsalud.org)

Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways. (stanford.edu)
Structural and functional studies of receptor/ligand interactions relevant to human health and disease in immunity, infection, and neurobiology. (stanford.edu)

The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors. (stanford.edu)

The role of IgE in asthma and allergy. (nottingham.ac.uk)
So, high-affinity IgE receptors-sometimes that can be an aggravating factor for people with allergic asthma. (consultantlive.com)
Raulf-Heimsoth , M et al "T-cell receptor repertoire expression in workers with occupational asthma due to platinum salt. (ersjournals.com)
Asthma is present in 10% to 15% of the adult population, induced BHR and airway inflammation, and thus far, the and it is estimated that up to 15% of all cases in industrialized physiological role of IgE in the airways has not been fully settings are associated with workplace exposure (Bauer et al. (cdc.gov)
Asthma in between disease status and IgE is stronger but on a group not man is defined as variable or intermittent airway obstruction on an individual basis (man: Liss et al. (cdc.gov)

MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. (frontiersin.org)

Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women? (springer.com)
PMID 23725541 ] Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics. (snpedia.com)

We examined the effect of flavones on the expression of the high-affinity IgE receptor FcεRI, which plays a central role in the IgE-mediated allergic response. (elsevierpure.com)

Except its established function for allergy, there is still speculation about the physiological contributions of IgE. (antibodies-online.com)

The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)

High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases. (snpedia.com)

After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (thermofisher.com)

A "private" receptor system, binding specifically IL-13 with high affinity, seems to use different signalling pathways and is increasingly being studied for its potential as a novel prognostic factor, biomarker or therapeutic target in different types of cancer. (wikipedia.org)
A discovery made in 2008 indicated that the FCER1A gene is responsible for encoding an alpha chain of high-affinity IgE receptors. (news-medical.net)
An examination of over 11,000 Germans led to the conclusion that rs2251746 (and one other FCER1A SNP, the tightly linked rs2427837 ) were strongly associated with high levels of serum IgE. (snpedia.com)
PMID 29243845 ] FcεR1α gene polymorphism shows association with high IgE and anti-FcεR1α in Chronic Rhinosinusitis with Nasal Polyposis. (snpedia.com)

These differences were not reported for Ara h 2, even though Peanuts from different varieties and from different parts of the world contain similar proteins and the IgE binding properties are similar. (loinc.org)

citation needed] There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. (wikipedia.org)

Allergies and the atopic reaction associated with them are mediated by IgE. (news-medical.net)
Now more than ever research is focusing on the genetic basis of atopic configuration due to the increasing incidence of IgE atopy and the fact that most common treatment options are only focused on relieving symptoms. (news-medical.net)

toll-like receptor pathway. (cdc.gov)

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)

IL-13 uses the IL-4 receptor type II (IL-4RII), a complex formed by an IL-4Rα chain and an IL-13Rα1 chain. (wikipedia.org)
The IL-4/IL-4Rα complex, however, can also bind to a different secondary chain, the IL-2Rγc, forming the IL-4 receptor type I (IL-4RI). (wikipedia.org)

Anatomy21

Organisms43

Diseases52

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes25

Technology, Industry, Agriculture5

Information Science3

Health Care1

Immunoglobulin14

Antibody6

Serum IgE levels3

Subunit6

Antigen8

Antibodies12

Specific IgE3

Histamine6

Cytokine4

CD233

ELISA2

Urticaria4

Total IgE1

Affinity receptor3

Epsilon4

Antagonists1

Cells20

Ligand2

Molecules1

Asthma5

Degranulation1

Polymorphisms2

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Physiological1

Common receptor1

Mediators1

CD201

High4

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Atopic2

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