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  • ligand
  • The locations of the ligand‐binding domains and the G protein‐coupling sites are indicated, as is the region of the mGlu 1α receptor containing the Homer‐binding domain and the calmodulin‐binding domains in other subtypes. (els.net)
  • Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate. (wikipedia.org)
  • neuronal
  • Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. (wikipedia.org)
  • Glutamate is also used by the brain to synthesize GABA (γ-Aminobutyric acid), the main inhibitory neurotransmitter of the mammalian central nervous system, which plays a role in regulating neuronal excitability throughout the nervous system and is also directly responsible for the regulation of muscle tone in humans. (wikipedia.org)
  • GRM5
  • Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. (wikipedia.org)
  • The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties: Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes mGluR2 (this receptor) and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. (wikipedia.org)
  • binds
  • which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD). (wikipedia.org)
  • transmembrane
  • The description of glutamate receptor structure, including its transmembrane elements, reveals a complex assembly of multiple semiautonomous extracellular domains linked to a pore-forming element with striking resemblance to an inverted potassium channel. (nih.gov)