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  • pathological
  • Overall our findings suggest that Foxa3 can be a potential target for the prevention of glucocorticoid-induced pathological side effects in adipose tissues. (pnas.org)
  • Phosphorylation
  • Phosphorylation (PO 4 ) is one way these receptors communicate with one another to support homeostatic reactions in learning and memory. (pnas.org)
  • transcription
  • Their target receptor, the GC receptor (GR), is a multi-tasking transcription factor, changing its role and function depending on cellular and organismal needs. (jci.org)
  • Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. (drugbank.ca)
  • Glucocorticoids (GCs) exert their biological and therapeutical actions through the GC receptor (GR), a ligand-dependent transcription factor. (csic.es)
  • The contribution of the N-and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific. (nii.ac.jp)
  • vitro
  • There was no correlation of receptor levels with in vitro [ 3 H]thymidine labeling indices, terminal deoxynucleotide transferase levels, FAB classification, or sex. (aacrjournals.org)
  • This study showed that, despite long-term treatment with oral glucocorticoids, there was no evidence of abnormalities in glucocorticoid receptor-binding characteristics in severe asthma, and moreover, it was demonstrated that glucocorticoid receptors were functional in vitro . (ersjournals.com)
  • The in vitro glucocorticoid response was investigated by evaluation of the release of regulated on activation, T-cells expressed and secreted (RANTES) by PBM in the presence or absence of dexamethasone from these same patients. (ersjournals.com)
  • variant
  • Piotrowska H & Jagodzinski PP Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. (abcam.com)
  • activity
  • Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-β, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-α. (rupress.org)