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  • baclofen
  • We observed that intrathecal administration of baclofen, a selective GABA-B agonist, exacerbated the inflammatory response in the knee after zymosan administration characterized by an increase in the neutrophil recruitment and knee joint edema, whereas saclofen, a GABA-B antagonist, exerted the opposite effect. (physiciansweekly.com)
  • gamma-amin
  • The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in a murine model of zymosan-induced arthritis by using different pharmacological tools. (physiciansweekly.com)
  • GABAergic
  • Together, these results demonstrate that the pharmacological manipulation of spinal GABAergic transmission aids control of neutrophil migration to the inflamed joint by modulating the activation of the knee joint-innervating sympathetic terminal fibers through a mechanism dependent on peripheral beta-adrenergic receptors and central components, such as p38 MAPK. (physiciansweekly.com)
  • 1995
  • 1995). GABA receptors are also located post-synaptically and when activated hyperpolarize the neuron thus decreasing the effectiveness of excitatory input (Malcangio and Bowery, 1996). (chiro.org)
  • mammalian
  • Overall, this study has revealed potential differences in the agonist binding pocket between nematode UNC-49 and mammalian GABA receptors that could be exploited in the design of novel anthelmintics. (aspetjournals.org)
  • agonist
  • In addition, the residue H142, which is unique to nematode UNC-49 GABA receptors, appears to play a negative role in GABA sensitivity as its mutation to cysteine increased sensitivity to GABA and caused the UNC-49 receptor partial agonist 5-aminovaleric acid (DAVA) to behave as a full agonist. (aspetjournals.org)
  • responses
  • Further openings via GABA binding to the receptor then produce inhibitory responses. (wikipedia.org)
  • A similar enhancement was also observed for the GABA C receptor-mediated responses (256 pA vs 171 pA for diabetic and control bipolar cells, respectively). (arvojournals.org)
  • In addition, the GABA C receptor-mediated responses on diabetic cells exhibit slower kinetics with GABA inactivation time constants of 1.77 seconds vs 1.57 seconds for control. (arvojournals.org)
  • Furthermore, we show how these GABA receptors modulate the time course of innate behavioral responses after odor pulse termination, demonstrating an important role for temporal contrast enhancement in odor-guided navigation. (nih.gov)
  • Functions also as histamine receptor and mediates cellular responses to histamine. (abcam.com)
  • bipolar
  • receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. (abcam.com)
  • GABA elicited larger currents on rod-bipolar cells isolated from diabetic retina (319 ± 9 pA) than those from age-matched controls (217 ± 8 pA). (arvojournals.org)
  • inhibits
  • Guvacine hydrochloride inhibits GABA uptake (IC50 values are 14, 58, 119 and 1870 uM for hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1 respectively). (adooq.com)
  • This study will use brain imaging to map brain cell receptors for a chemical called GABA, a chemical that inhibits the activities of nerve cells. (clinicaltrials.gov)
  • prefrontal cortex
  • In addition, L. rhamnosus ( JB-1 ) reduced GABA Aα2 mRNA expression in the prefrontal cortex and amygdala, but increased GABA Aα2 in the hippocampus. (pnas.org)
  • whereas
  • Whereas sodium-independent GABA binding appears to represent attachment to the electrophysiologically relevant recognition site for this substance, the binding detected in the presence of sodium has the characteristics of a transport rather than a recognition site. (springer.com)
  • mRNA
  • Interest in RDL as a model ligandgated anion channel has been enhanced by the recent discovery of pre-mRNA A-to-I editing, which, together with alternative splicing, adds to the functional diversity of this GABA receptor subunit. (aspetjournals.org)
  • In this work, we show that chronic treatment with L. rhamnosus ( JB-1 ) induced region-dependent alterations in GABA B1b mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus , in comparison with control-fed mice. (pnas.org)
  • intracellular
  • According to the excitatory GABA theory, this phenomenon is due to increased intracellular concentration of Cl¯ ions either during development of the nervous system or in certain cell populations. (wikipedia.org)
  • assays
  • In order to fully exploit the potential of receptor binding assays and to avoid the misinterpretation of data, it is essential to have an understanding of the fundamental principles that govern this procedure. (springer.com)
  • Binding
  • By modifying the tissue preparation, e.g. by pre-incubating with detergent or extensively washing the membranes, it is possible to identify a second, kinetically distinct, sodium-independent GABA binding site. (springer.com)
  • expression
  • They also examine the therapeutic potential that remains in the cloning and expression of the GABA transporter, and in developing additional agents capable of regulating GABA receptor function. (waterstones.com)
  • While the levels of GABA rho1 subunit expression were comparable in diabetic and normal retinas, there was a significant enhancement in the ratio of rho1/rho2 subunit expression in the diabetic animals. (arvojournals.org)
  • Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. (pnas.org)
  • functional
  • Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. (abcam.com)
  • EC50
  • It was found that of the 18 loop E mutants analyzed, H142C, R147C and S157C had significant changes in GABA EC50 and were accessible to modification by a methanethiosulfonate reagent (MTSET) resulting in a change in IGABA. (aspetjournals.org)