• Statistical comparison of all inhibitory and activating killer cell immunoglobulin receptors (KIRs) between controls, survivors, and persons who died of Ebola virus disease in Guinea, 2015-2017. (cdc.gov)
  • HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis progression. (tmu.edu.tw)
  • Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. (amsterdamumc.org)
  • The functional IL-36 receptor is a heterodimer containing interleukin-1 receptor-like 2 ( IL1RL2 ) as the ligand binding moeity and the IL-1 receptor accessory protein ( IL1RAP ). (guidetoimmunopharmacology.org)
  • Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells. (silverchair.com)
  • Cells infected with herpes simplex virus type 1 (HSV-1) express a cell surface receptor able to bind to the Fc region of immunoglobulin G (IgG). (lu.se)
  • 2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
  • pIgR has a strong specificity to polymeric immunoglobulins and is not responsive to monomeric immunoglobulin. (wikipedia.org)
  • The process of transporting polymeric immunoglobulins from the basolateral to apical side, known as transcytosis, is composed of several distinct steps. (wikipedia.org)
  • The polymeric immunoglobulin receptor (pIg-R) is responsible for the receptor-mediated transcytosis of polymeric immunoglobulins (IgA and IgM) across various epithelia. (silverchair.com)
  • It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. (wikipedia.org)
  • Keith Mostov and colleagues found that secretory component was a proteolytic fragment of a transmembrane precursor, the pIgR, which led them to propose the currently accepted model Polymeric immunoglobulin receptor is responsible for transcytosis of soluble dimeric IgA, pentameric IgM, and immune complexes from the basolateral to the apical mucosal epithelial cell surface. (wikipedia.org)
  • Transcytosis is initiated by either the binding of dimeric IgA to the receptor or the phosphorylation of Ser-664 residue of the receptor. (wikipedia.org)
  • The neonatal Fc receptor (FcRn) mediates the transcytosis of maternal immunoglobulin G (IgG) across fetal and/or neonatal tissues for the acquisition of passive immunity. (rcsb.org)
  • You can now search immunoglobulin (Ig) nucleotide sequences against the Constant region (C) gene database (Figure 1) to determine the Ig isotypes including subtypes (IgM, IgG, IgA1, etc. (nih.gov)
  • dblp: IMGT/LIGM-DB, the IMGT ® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences. (dagstuhl.de)
  • Available residual clinical serum specimens were collected from prior SARS-CoV-2 infection, serum antibody levels (anti-spike fully vaccinated hospitalized control patients at all sites and tested immunoglobulin G [IgG] and anti-receptor binding domain at CDC. (cdc.gov)
  • History Immunoglobulin (IG or antibody) as well as the T-cell receptor TH-302 (TR) are pivotal protein in the disease fighting capability of higher microorganisms. (researchatlanta.org)
  • For instance trastuzumab (trade name Herceptin) a humanized antibody that targets the human epidermal growth factor receptor. (researchatlanta.org)
  • Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. (wikipedia.org)
  • The extracellular portion of the protein contains 6 domains: 5 evolutionary conserved immunoglobulin-like domains, and 1 non-homologous domain, which is involved in proteolytic cleavage of pIg-pIgR complex from the apical side of the IECs. (wikipedia.org)
  • Interaction of IL-1 and TNF-α with their receptors ultimately lead to transcriptional activation of PIGR gene due to nuclear translocation of NF-kB. (wikipedia.org)
  • Polymeric immunoglobulin receptor (pIgR) is essential for the proper functioning of the mucosal immune system. (sandiego.edu)
  • Moreover in recent years these antigen receptor proteins have attracted attention in the field of cancer immunotherapy to elevate the patient's immune response against tumor cells with few side-effects [10 11 In cellular immunotherapy T cells recognizing tumor-associated antigens can be administrated back to patients after ex vivo culture and processing for immune response enhancement. (researchatlanta.org)
  • NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
  • novel DAP-12-coupled 'activating' CD33rSiglecs have been identified such as siglec-14 and siglec-16 which are paired with the inhibitory receptors siglec-5 and siglec-11 respectively. (hiv-proteases.com)
  • 2. Bulut Y, Faure E, Thomas L, Equils O, Arditi M. (2001) Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. (guidetopharmacology.org)
  • These data indicate that the HSV Fc receptor requires both the C gamma 2 and C gamma 3 domains for interaction with the IgG molecule analogous to the known interaction of protein A of Staphylococcus aureus, the Fc binding proteins of Group A, C and G streptococci, and certain human rheumatoid factors. (lu.se)
  • The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)
  • These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
  • Adaptive Immune Receptor Repertoire (AIRR) format is more consistent with AIRR specs including changing undefined type (NON, N/A) to empty string, not appending "reversed" to sequence identifier when the query is in reversed orientation, and using standard locus names such as IGH, TRB instead of traditional VH, VB etc. (nih.gov)
  • Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
  • Together, our data indicate that SLAMF receptors are important modulators of the BCR signaling axis and may improve immune control in CLL by interference with NK cells. (nature.com)
  • Signaling Lymphocytic Activation Molecule Family (SLAMF) receptors are a group of nine type I transmembrane receptors that are mainly expressed on a variety of immune cells. (nature.com)
  • In the work presented here, we provide compelling data that SLAMF1 and SLAMF7 receptors may not only enhance immune control of CLL but also negatively regulate BCR signaling and thereby impact sensitivity towards BTK inhibition in the substantial fraction of patients with SLAMF1 or SLAMF7 expressing M-CLL. (nature.com)
  • Toll-like receptors (TLR) and nucleotide oligomerization domain (NOD)-like innate immune pathways respond to these exposures. (cdc.gov)
  • Large animal confinement farm ing exposures produce a wide spectrum of upper and lower respiratory tract diseases due to the complex diversity of organic dust, particulates, microbial cell wall components, and gases and resultant activation of various innate immune receptor signaling pathways. (cdc.gov)
  • Configuration of immunoglobulin and T cell receptor beta and gamma genes in acute myeloid leukaemia: pitfalls in the analysis of 40 cases. (bmj.com)
  • Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. (lu.se)
  • We have now established a new data pre-processing procedure to eliminate artifacts caused by a 5'-RACE library generation process, reanalyzed a previously studied data set defining human immunoglobulin heavy chain genes, and identified novel upstream regions, as well as previously identified upstream regions that may have been identified in error. (lu.se)
  • The gene has been cloned independently as ILT6 [ immunoglobulin-like transcript 6 ], LIR4 [ leukocyte immunoglobulin-like receptor 4 ], HM43 . (copewithcytokines.org)
  • This gene encodes a receptor tyrosine kinase. (nih.gov)
  • Anti-TLR-IgA are chimeric monoclonal antibodies specific for Toll-like receptor. (invivogen.com)
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • TPOAb and TgAb are polyclonal antibodies of the immunoglobulin G (IgG) class. (medscape.com)
  • The stimulating TRAb are oligoclonal antibodies of the immunoglobulin G1 (IgG1) subclass. (medscape.com)
  • The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (expasy.org)
  • We've released a new version (1.16.0) of IgBLAST , the popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences. (nih.gov)
  • However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. (lu.se)
  • Inference from large, rearranged immunoglobulin transcriptome data sets offers an opportunity to define the upstream regions (5'-untranslated regions and leader sequences). (lu.se)
  • The composition of the receptor is complex, including 6 immunoglobulin-like domains, a transmembrane region, and an intracellular domain. (wikipedia.org)
  • The quite long intracellular domain of the receptor, along with the transmembrane region, is responsible for the transduction of highly conserved signals. (wikipedia.org)
  • Cleavage occurs at the junction of the transmembrane region of the receptor and domain 5. (wikipedia.org)
  • Predicted to enable transmembrane signaling receptor activity. (nih.gov)
  • Background Discussion between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. (ap26113.com)
  • However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
  • The cytokines IL-36α , IL-36β and IL-36γ are agonists of the IL-36 receptor. (guidetoimmunopharmacology.org)
  • The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells. (nih.gov)
  • It is metabolized so one iodine atom is removed to produce T3 - about 10 times as active as T4 in binding to a receptor that exerts the action as receptor to the thyroid hormone. (cdc.gov)
  • mice probably through improved B-cell receptor signalling. (hiv-proteases.com)
  • Over-expression of siglec-G inhibited B-cell-receptor-mediated Ca2+ signalling and the siglec-G-deficient B1a cells exhibited exaggerated calcium signalling and improved IgM production.41 A similar phenotype has been observed in Ibodutant (MEN 15596) SHP-1-deficient mice which show expansion of the B1-cell populace and higher B-cell receptor-induced calcium signalling in B cells. (hiv-proteases.com)
  • Since SLAMF receptors play a role in NK cell biology, we reasoned that these receptors may impact NK cell-mediated CLL immunity. (nature.com)
  • Since the SLAMF low signature was strongly associated with an unmutated CLL immunoglobulin heavy chain (IGHV) status in large datasets, we investigated the impact of SLAMF1 and SLAMF7 on the B cell receptor (BCR) signaling axis. (nature.com)
  • Overexpression of SLAMF1 or SLAMF7 in IGHV mutated CLL cell models resulted in reduced proliferation and impaired responses to BCR ligation, whereas the knockout of both receptors showed opposing effects and increased sensitivity toward inhibition of components of the BCR pathway. (nature.com)
  • B cell receptor (BCR) signaling plays a critical role in driving proliferation and survival of the malignant clone in chronic lymphocytic leukemia (CLL), supported by the clinical activity of inhibitors targeted toward BCR-associated kinases [ 1 ]. (nature.com)
  • A previous study demonstrated that SLAMF1, SLAMF2, and SLAMF7 receptors are rather downregulated on CLL cells as compared to their normal B cell counterpart [ 12 ], suggesting that high expression of these molecules may have detrimental (e.g., antiproliferative) effects in the CLL context. (nature.com)
  • Synthetic peptide corresponding to Human VEGF Receptor 2 (phospho Y951). (abcam.com)
  • These observations suggest that there is another receptor for the myelin-associated proteins. (jneurosci.org)
  • T3 binds to the nuclear receptor (TR) and combines with another receptor (RXR) then combines with a receptor element on DNA. (cdc.gov)
  • Based on a wealth of validating preclinical studies, we contend that the favorable metabolic effects of mineralocorticoid receptor antagonists, such as spironolactone, support their inclusion in novel immunosuppressive strategies to inhibit new onset type II diabetic symptoms in post-transplantation patient populations. (medscimonit.com)
  • and positive regulation of immunoglobulin production in mucosal tissue. (nih.gov)
  • Contains 3 Immunoglobulin-like C2-type domains. (lu.se)
  • 3. Garlanda C, Di Liberto D, Vecchi A, La Manna MP, Buracchi C, Caccamo N, Salerno A, Dieli F, Mantovani A. (2007) Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. (guidetopharmacology.org)
  • In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • There is lower prevalence of immunoglobulin (Ig) E-mediated asthma and atopy in farm ers and their children, but organic dust worsens existing asthma. (cdc.gov)
  • 2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. (guidetopharmacology.org)
  • This study aimed to elucidate the relationship between local and systemic inflammation in smoking-induced COPD by assessing levels of soluble (s) tumor necrosis factor (TNF) receptors, TNF-alpha, and interleukin-8 (IL-8) in induced sputum and in plasma. (nih.gov)
  • When comparing sTNF receptors in sputum and plasma, no direct correlations were found despite elevation of circulating sTNF-R75 levels in patients with COPD. (nih.gov)
  • We identified a subset of Chronic Lymphocytic Leukemia (CLL) patients with high Signaling Lymphocytic Activation Molecule Family (SLAMF) receptor-related signaling that showed an indolent clinical course. (nature.com)
  • Ils ont été répartis en deux groupes : 12 patients souffrant d'une thrombocytopénie à médiation immunitaire (groupe 1) et 12 patients atteints d'une thrombocytopénie à médiation non immunitaire (groupe 2). (who.int)
  • They have been selected for there ability to efficiently neutralize Toll-like receptor activation. (invivogen.com)
  • Activation by these agonists is opposed by the IL-36 receptor antagonist (IL-36RA) cytokine. (guidetoimmunopharmacology.org)
  • In B cells, this class of receptors has been shown to be expressed in distinct patterns associated with development and activation [ 11 ]. (nature.com)