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  • peripheral
  • Beta-endorphin and metenkephalin stimulate human peripheral blood mononuclear cell chemotaxis. (springer.com)
  • β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. (wikipedia.org)
  • The opioid receptors are distributed throughout the central nervous system and within the peripheral tissue of neural and non-neural origin. (wikipedia.org)
  • β-Endorphin in global pathways diffuse to different parts of the body through cerebral spinal fluid in the spinal cord, allowing for β-endorphin release to affect the peripheral nervous system. (wikipedia.org)
  • The two main methods by which β-endorphin is utilized in the body are peripheral hormonal action and neuroregulation. (wikipedia.org)
  • depression
  • 5-HT1A receptor agonists like buspirone and flesinoxan show efficacy in relieving anxiety and depression, and buspirone and tandospirone are currently approved for these indications in various parts of the world. (wikipedia.org)
  • Function
  • Tetraploidization events often result in the loss of one or more of the duplicated genes, but in this case, nearly all species retain all four opioid receptors, indicating important and specific function. (wikipedia.org)
  • β-Endorphin function is said to be divided into two main categories: local function and global function. (wikipedia.org)
  • sites
  • By the mid-1960s, it had become apparent from pharmacologic studies that opiate drugs were likely to exert their actions at specific receptor sites, and that there were likely to be multiple such sites. (wikipedia.org)
  • specific
  • In many cases, specific receptors for these various chemotactic factors have been defined on both PMNs and monocytes (6-10). (springer.com)
  • Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. (springer.com)
  • Effects
  • Melanocortins and the brain: From effects via receptors to drug targets. (springer.com)
  • Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. (springer.com)