• As a member of the endoplasmic reticulum protein family, POGLUT2 functions to prevent the secretion of all endoplasmic reticulum resident proteins via receptor-ligand interaction with a protein in the Golgi apparatus by a Lys-Asp-Glu-Leu or KDEL motif located at its C-terminus ( 7 , 8 ). (frontiersin.org)
  • There are specific receptor proteins like integrin on the external surface of focal attachments. (omicsonline.org)
  • And the internal surface has actin filaments such as talin, paxillin, vinculin, tensin and proteins that provide interactions between membrane receptor proteins [ 1 - 3 ]. (omicsonline.org)
  • Many proteins in adhesion plaque such as integrin, cytoskeleton proteins, proteases, protein kinases, phosphatases take part in signal transferring by co-localizing with vinculin and talin [ 3 ]. (omicsonline.org)
  • Western blot analysis of phosphotyrosinated proteins demonstrated that BK reduced tyrosine phosphorylation of several proteins among which we identified the 125-focal adhesion kinase. (nih.gov)
  • Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)
  • Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both endothelial and tumor cells, are one of the key proteins contributing to cancer development, and are involved in drug resistance. (researchgate.net)
  • These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
  • To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
  • In general, cell adhesion favours cell survival signalling, and integrins are the main receptors responsible for mediating the attachment of different types of cells to matrix proteins. (lu.se)
  • Increased adhesion of the cancer cells depended on activation of cyclooxygenase-2, an enzyme that is involved in progression of colon cancers, whereas adhesion of the intestinal epithelial cells was augmented by LTD4-induced translocation of protein kinase C to areas where integrins bind to matrix proteins (focal adhesions). (lu.se)
  • Determining the function of CMV-encoded chemokine receptors in the context of viral pathogenesis and acceleration of vascular disease. (ohsu.edu)
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
  • There are therefore three possible signaling states for dependence receptors: on (ligand-bound, migration and proliferation), off (ligand-unbound, apoptosis inducing) and absent (lack of signal). (wikipedia.org)
  • In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
  • In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
  • The relationship between cell proliferation, protein tyrosine phosphorylation, phosphotyrosine kinase activity and bradykinin receptor activation in rat mesangial cells was investigated. (nih.gov)
  • We demonstrated that bradykinin (BK), through the B2 receptor, induced a dose-dependent inhibition of mesangial cell proliferation stimulated by fetal calf serum. (nih.gov)
  • Taken together, these data suggest for the first time that, in proliferating rat mesangial cells, B2 receptor stimulation is able to induce, via a pertussis insensitive pathway, the inhibition of tyrosine kinase activity and mesangial cell proliferation. (nih.gov)
  • Collectively, this type of receptor is known as a dependence receptor because the unbound pathway is usually apoptotic, meaning that cell survival depends on ligand presence. (wikipedia.org)
  • Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. (gla.ac.uk)
  • Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. (gla.ac.uk)
  • We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway, Focal Adhesion, Insulin Signaling, which may be useful for your reference. (creativebiomart.net)
  • After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
  • Our laboratory studies signal transduction pathways coupled to G protein-coupled receptors. (bu.edu)
  • Overproduction of sLR11 decreased the sensitivity of Ang II-induced activation pathways to inhibition by an Ang II type 1 receptor blocker in mice. (jci.org)
  • These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
  • A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS, including the EPHB1 RECEPTOR. (bvsalud.org)
  • Turning depended on the activation of integrins-the LN1 receptors. (rupress.org)
  • Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
  • We have unequivocally established that direct signalling occurs between the LTD4 receptor and the collagen integrins in two different cell lines respectively derived from human colon carcinoma and intestinal epithelial cells. (lu.se)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
  • The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
  • In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
  • Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
  • DCC and neogenin, two of the netrin-1 receptors, have recently been shown to have sites for tyrosine phosphorylation (at Y1420 on DCC) and are likely interacting with Src family kinases in regulating responses to netrin-1. (wikipedia.org)
  • Gene expression may be affected in benign familial pemphigus, as may phosphorylation of adhesion molecules. (medscape.com)
  • Slack, B.E. and Blusztajn, J.K. (2008) Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. (bu.edu)
  • ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)
  • Focal adhesions are integrin-mediated cell matrix junctions connecting the ECM to the actin cytoskeleton. (rupress.org)
  • This thesis is focused primarily on the effect that LTD4 has on reorganisation of the actin cytoskeleton and on cell-cell and cell-matrix adhesion properties. (lu.se)
  • DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1. (wikipedia.org)
  • Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)
  • Focal adhesion targeting (FAT) domains target the non-receptor tyrosine kinases FAK and Pyk2 to cellular focal adhesion areas, where the signaling molecule paxillin is also located. (rcsb.org)
  • Mutations on DLC-1 perturb the interaction with cten and disrupt the focal adhesion localization of DLC-1. (rupress.org)
  • Considerable amounts of the shed soluble form of the LDL receptor relative LR11 (sLR11) produced by intimal SMCs enhance SMC migration in vitro via upregulation of urokinase-type plasminogen activator receptor (uPAR) expression. (jci.org)
  • Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. (medlineplus.gov)
  • We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)
  • In recent work, we have examined aspects of the regulation of mitogen-activated protein kinases (MAPK), mammalian target of rapamycin (mTOR), and integrin-dependent signaling by muscarinic receptor subtypes. (bu.edu)
  • Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. (gla.ac.uk)
  • Focal attachments have 10-15 nm distance between the cell membrane and the material surface and they are tight connections. (omicsonline.org)
  • In isolated murine SMCs, sLR11 caused membrane ruffle formation via activation of focal adhesion kinase/ERK/Rac1 accompanied by complex formation between uPAR and integrin αvβ3, a process accelerated by Ang II. (jci.org)
  • Netrin receptor DCC is a single transmembrane receptor. (wikipedia.org)
  • Several years later DCC was shown to encode a transmembrane receptor protein that mediated the effects of netrin-1 on axon outgrowth. (wikipedia.org)
  • These junctions consist of calcium-binding transmembrane glycoproteins, which contribute to cellular adhesion. (medscape.com)
  • More recently DCC has been characterized as a dependence receptor, and many hypotheses have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced. (wikipedia.org)
  • Historically, cellular receptors have been thought to be activated when bound to their ligand, and are relatively inactive when no ligand is present. (wikipedia.org)
  • These receptors are active both with ligand bound and unbound, but the signals transmitted are different when the receptors are ligand bound. (wikipedia.org)
  • providing a ligand for the α6β1 integrin receptor expressed by OLs. (jneurosci.org)
  • Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
  • Small peptides containing the RGD sequence can modulate a variety of cell adhesion invents associated with thrombosis, inflammation, and tumor metastasis. (embl.de)
  • The tensin family member cten (C-terminal tensin like) is an Src homology 2 (SH2) and phosphotyrosine binding domain-containing focal adhesion molecule that may function as a tumor suppressor. (rupress.org)
  • When these DLC-1 mutants were fused to a focal adhesion targeting sequence, their tumor suppression activities were significantly restored. (rupress.org)
  • These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. (rupress.org)
  • These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
  • Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
  • The subsequent activation of focal adhesion kinases might activate or recruit myosin II. (rupress.org)
  • Work from my laboratory and others has established roles for G protein-coupled (including muscarinic) receptors, growth factor receptors, protein kinases and calcium influx as activators of APP ectodomain shedding. (bu.edu)
  • Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. (wikipedia.org)
  • [ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)
  • The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. (lu.se)
  • Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
  • This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
  • When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)
  • On polyornithine, both myosin II and focal complexes are randomly distributed. (rupress.org)
  • On LN1, however, myosin IIB concentrated in the transitional domain of the growth cone-intermingled with or just behind the new front of focal complexes. (rupress.org)
  • Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of primary glomerular diseases in adults. (medscape.com)
  • University Graz, Graz (B. Kölli, W. Buzina) inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors). (cdc.gov)
  • We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. (embl.de)
  • An overall defect in keratinocyte adhesion appears to be secondary to a primary defect in a calcium pump protein, ATP2C1. (medscape.com)
  • Other ADAM substrates being studied in this laboratory include the discoidin domain receptor (DDR)1, which undergoes ectodomain shedding in response to collagen binding, and ADAM10 itself, which is constitutively cleaved by ADAM9 and ADAM15 to generate a soluble ectodomain, and a C-terminal fragment that is a substrate for gamma-secretase. (bu.edu)
  • Slack, B.E., Siniaia, M.S., and Blusztajn, J.K. (2006) Collagen type I selectively activates ectodomain shedding of the discoidin domain receptor I: Involvement of Src tyrosine kinase. (bu.edu)
  • Chemokines and their corresponding receptors have been well-characterized in RA progression, but less so in OA pathogenesis. (researchsquare.com)
  • Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
  • However, it is becoming increasingly clear that these factors and their receptors are also widely found to express across many different cancers with further research. (medsci.org)
  • This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. (nih.gov)
  • 2- Adhesion phase takes longer and makes a stronger attachment. (omicsonline.org)