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  • epidermal
  • Abstract -The signaling cascade elicited by angiotensin II (Ang II) resembles that characteristic of a growth factor, and recent evidence indicates transactivation of epidermal growth factor receptor (EGF-R) by G protein-coupled receptors. (ahajournals.org)
  • Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. (springer.com)
  • Rotational diffusion of epidermal growth factor complexed to its surface receptor the rapid microaggregation and endocytosis of occupied receptors. (springer.com)
  • Hillman GM, Schlessinger J. The lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis. (springer.com)
  • High-affinity epidermal growth factor receptors on the surface of A-431 cells have restricted lateral diffusion. (springer.com)
  • high-affinity
  • Cardiac fibroblasts isolated from neonatal rat hearts have abundant high-affinity angiotensin II (Ang II) receptors, which are classified pharmacologically as belonging to the Ang II type 1 receptor (AT 1 ) subtype. (ahajournals.org)
  • Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. (google.es)
  • Peptides
  • In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides. (google.es)
  • gene
  • We isolated the rat fibronectin gene, including the 5′-flanking region, and found that the activator protein-1 (AP-1) binding site present in the promoter region was responsible for the Ang II responsiveness of this gene. (ahajournals.org)
  • interaction
  • In this review, we will focus on the host NPPC receptors that are involved in the molecular interaction with S. aureus to accomplish bacterial internalization. (hindawi.com)
  • As will be dis-cussed below, these include tyrosine kinase receptors, as already hinted at in chapter 4, as well as receptors mediating binding to the cell substratum or cell-cell interaction. (springer.com)
  • implications
  • Finally, we will discuss the medical implications derived from this knowledge and show a summary of the host receptors related to S. aureus internalization in NPPCs in Figure 1 . (hindawi.com)
  • signal
  • In these cases, immobilization of receptors through dimerization/aggregation and/or complexation with cytosolic, cytoskeletal or extracellular components appears to represent the primary stimulus triggering signal transduction. (springer.com)
  • Fahrenholz F, Jans DA, Peters R. Lateral mobility of the V1- and V2-receptors in plasma membranes: a role in signal transduction and receptor down-regulation. (springer.com)
  • The mobile receptor hypothesis revisited: a mechanistic role for hormone receptor lateral mobility in signal transduction. (springer.com)
  • Jans DA, Pavo I. A mechanistic role for polypeptide hormone receptor lateral mobility in signal transduction. (springer.com)
  • sequence
  • Several receptors have now been identified which recognize the Arg-Gly-Asp sequence of their respective ligands. (google.es)
  • An alternative possibility is that the Arg-Gly-Asp sequence provides essentially all of the information for the receptor binding and that it is the conformation of this sequence that gives an adhesion protein its receptor specificity. (google.es)
  • function
  • Ang II-induced fibronectin mRNA was not affected by protein kinase C inhibitors or protein kinase C depletion, whereas specific inhibition of EGF-R function by a dominant negative EGF-R mutant and tyrphostin AG1478 abolished induction of fibronectin mRNA. (ahajournals.org)
  • subsequent
  • As we saw in chapter 6, immobilization of hormone-occupied receptors plays an impor-tant role in downregulating response subsequent to hormonal stimulation in GTP-binding protein activating systems. (springer.com)