• For example, raloxifene is classified as a SERM because it (like estrogen) prevents bone loss and lowers serum cholesterol but unlike estrogen, does not stimulate the uterus to grow a lining. (cancer.org)
  • These monoclonal antibodies should prove useful in the study of estrogen receptors of human reproductive tissues, in particular for the radioimmunochemical assay and immunocytochemical localization of receptors in breast cancers. (pnas.org)
  • In 1958, using a radioactive marker, he showed that only the tissues that respond to estrogen, such as those of the female reproductive tract, were able to concentrate injected estrogen from the blood. (uchicago.edu)
  • In 1967, Jensen and Jack Gorski of the University of Wisconsin showed that these putative receptors were macromolecules that could be extracted from these tissues. (uchicago.edu)
  • The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (abcam.com)
  • Androgen receptors (ARs) are found in a wide variety of tissues, including reproductive organs, central ner. (novusbio.com)
  • A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues. (wikidoc.org)
  • The prevailing theory to explain estrogen action throughout the 1950s was that estrogens exert their actions by participating in enzymatic processes of metabolism. (aacrjournals.org)
  • But what the researchers found in invasive lobular carcinomas - the specific cancer they studied - may also be true of tamoxifen resistance in other cancer types," she said "No one has looked for gamma estrogen-related receptors in tamoxifen resistance in invasive ductal carcinoma. (medicalnewstoday.com)
  • Furthermore, analysis of ERβ binding to examples of the three classes of responsive genes showed that differential binding of the receptor is not the main determinant of responsiveness, because ERβ bound to all three classes of genes. (sciencemag.org)
  • With this method, Jensen showed that when estrogen bound to this receptor, the compound then migrated to the nucleus where it bound avidly and activated specific genes, stimulating new RNA synthesis. (uchicago.edu)
  • Discover related pathways, diseases and genes to Estrogen Receptor. (novusbio.com)
  • Once activated by estrogen, the ER is able to translocate into the nucleus and bind to DNA to regulate the activity of different genes (i.e. it is a DNA-binding transcription factor). (wikipedia.org)
  • In humans, the two forms of the estrogen receptor are encoded by different genes, ESR1 and ESR2 on the sixth and fourteenth chromosome (6q25.1 and 14q23.2), respectively. (wikipedia.org)
  • In conclusion our data could provide new insights as concerns the estrogen-related mechanisms of immune system modulation. (nih.gov)
  • The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation. (freepatentsonline.com)
  • Jensen, 84, is being honored for his pioneering research on how steroid hormones, such as estrogen, exert their influence. (uchicago.edu)
  • explored the gene regulatory activity of estrogen receptor β, a similar molecule with quite distinct antiproliferative and anti-inflammatory biological effects that are less well characterized than those of ERα. (sciencemag.org)
  • If you have an ER- cancer: strategies to increase or decrease estrogen levels will have no bearing on your recurrence risk. (oncolink.org)
  • I talked to my onco last week and asked him the type of cancer cells I had in regard to estrogen reception. (cancer.org)
  • There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively). (wikipedia.org)
  • The main function of the estrogen receptor is as a DNA binding transcription factor that regulates gene expression. (phys.org)
  • Sichun Yang, Ph.D., assistant professor at Case Western Reserve University, is working to understand the signaling mechanisms of two critical domains in estrogen receptors, using computer modeling resources at OSC. (osc.edu)
  • Furthermore what agent is used (estrogen, SERM, bisphosphonates) may vary over a woman's life time. (medindia.net)
  • We investigated the estrogenic activities of isoflavone derivatives in competition binding assays with human estrogen receptor (hER) α or hER β protein, and in a gene expression assay using a yeast system. (go.jp)
  • These two receptors are not closely related - they are more like distant cousins than siblings, researchers say, adding that understanding how these gamma estrogen-related receptors work may - eventually - help in designing new, more effective drugs targeting these receptors. (medicalnewstoday.com)
  • The next step of a drug discovery project is to identify environmental substances that may have an effect in humans similar to an effect produced by a naturally occurring estrogen. (osc.edu)
  • Researchers have engineered new sensors that fluoresce in the presence of compounds that interact with estrogen receptors in human cells. (phys.org)
  • More than 1,000 attended a simultaneous symposium on the metabolic processing of estrogen. (uchicago.edu)
  • The ERβ isoforms receptor subtypes can transactivate transcription only when a heterodimer with the functional ERß1 receptor of 59 kDa is formed. (wikipedia.org)