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  • Type
  • Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. (lsbio.com)
  • distinct
  • While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. (lsbio.com)
  • Inhibitors
  • Inhibitors of endothelin. (springer.com)
  • The suggestion of analyzing responses to treatment between those subjects receiving angiotensin-converting enzyme inhibitors (ACE-Is) alone with those receiving a combination of an ACE-I and angiotensin receptor blocker (ARB) is well received. (ahajournals.org)
  • downregulation
  • 11 This agrees with the prior demonstration of normal or only slightly depressed responses to ET-1 and the absence of important downregulation of endothelin receptors in blood vessels or smooth muscle cells of SHR. (ahajournals.org)
  • To test whether downregulation of endothelial ET B R expression/activity plays a role in HTN-Preg, BP was measured in normal pregnancy (Norm-Preg) rats and rat model of HTN-Preg produced by reduction of uteroplacental perfusion pressure (RUPP), and mesenteric microvessels were isolated for measuring diameter, [Ca 2+ ] i , and endothelin receptor type-A and ET B R levels. (ahajournals.org)
  • agonist
  • However, a selective ETB receptor agonist, Sarafotoxin 6c (S6c) caused a time-dependent ERK1/2 activation with a maximal effect by less than 20% of the ET-1-induced activation of ERK1/2. (lu.se)
  • kidney
  • Endothelins stimulate the contraction in almost all other smooth muscles (e.g., uterus, bronchus, vas deferens, stomach) and stimulate secretion in several tissues e.g., kidney, liver and adrenals [ PMID: 16340664 , PMID: 8480469 , PMID: 8466176 ]. (ebi.ac.uk)
  • Endothelin peptides and the kidney. (ebi.ac.uk)
  • Endothelins in the kidney: physiology and pathophysiology. (springer.com)
  • Methods: We determined the effect of HS and resuscitation by hypertonic saline (saline) or centhaquin on ETA and ETB receptor levels in the brain, heart, kidney, liver, lung and abdominal aorta. (ovid.com)
  • Endothelin regulates angiotensin-converting enzyme in the mouse kidney. (springer.com)
  • A subtype of endothelin receptor found predominantly in the KIDNEY. (curehunter.com)
  • mRNA
  • Endothelin-1 and its mRNA in the wall layers of human arteries ex vivo. (springer.com)
  • Endothelin-1 mRNA abundance in aorta and mesenteric arteries was measured by Northern blot analysis. (biomedsearch.com)
  • ETA receptor messenger RNA (mRNA) levels were high in follicular cells as well as in CL during luteal regression. (ovid.com)
  • At this latter stage, high ETA receptor expression concurred with low prostaglandin F2α receptor mRNA. (ovid.com)
  • cAMP elevating agents, forskolin and LH, suppressed ETA receptor mRNA expression in luteinized theca cells (LTC). (ovid.com)
  • In luteinized granulosa cells (LGC), 10 and 100 ng/ml of insulin-like growth factor I and insulin (only at a concentration of 2000 ng/ml) markedly decreased ETA receptor mRNA levels. (ovid.com)
  • insulin (in LGC) and forskolin (in LTC) enhanced progesterone production while inhibiting ETA receptor mRNA levels. (ovid.com)
  • inhibits
  • Garvin J, Sanders K. Endothelin inhibits fluid and bicarbonate transport in part by reducing Na+/K+ ATPase activity in the rat proximal straight tubule. (springer.com)
  • PMID
  • As a result, endothelins are implicated in a number of vascular diseases, including the heart, general circulation and brain [ PMID: 11984741 , PMID: 16529555 , PMID: 1331845 ]. (ebi.ac.uk)
  • Endothelin receptors have also been found in the brain, e.g. cerebral cortex, cerebellum and glial cells [ PMID: 1847708 , PMID: 2156267 ]. (ebi.ac.uk)
  • This receptor-mediated clearance mechanism is particularly important in the lung, which clears about 80% of circulating endothelin-1 [ PMID: 11067800 , PMID: 11264479 ]. (ebi.ac.uk)
  • Both receptors are localised to non-vascular structures such as epithelial cells as well as occurring in the central nervous system (CNS) on glial cells and neurones, where they are thought to mediate neurotransmission and vascular functions [ PMID: 9239759 ]. (ebi.ac.uk)
  • peptides
  • It has the same affinity at the ET B receptor as ET-1 but, at physiological concentrations, has little or no affinity for the ET A . The only endogenous peptides with a high degree of sequence similarity to the ETs are the sarafotoxins (S6a, S6b, S6c, S6d). (guidetopharmacology.org)
  • type
  • Intraventricular endothelin-1 uncouples the blood flow: metabolism relationship in periventricular structures of the rat brain: involvement of L-type calcium channels. (ebi.ac.uk)
  • The ET-1+endothelin receptor type-A antagonist BQ-123 and the ET B R agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg. (ahajournals.org)