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  • specific receptors
  • Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. (genome.jp)
  • chemotactic
  • A general understanding previously had been achieved, in other inflammatory contexts, of the mechanisms of leukocyte-endothelial interactions in the form of rolling, adhesion, and migration from the blood compartment through the endothelium as a result of the actions of selectins, adhesion molecules, and chemotactic cytokines called chemokines. (ahajournals.org)
  • Acute
  • Cytokines are key players in the triggering of inflammation and development of the acute phase response (APR). (bmj.com)
  • interleukin-17
  • Th17 cells are a distinct lineage of CD4 + T helper (Th) cells that produce the cytokines IL-17 (interleukin-17) and IL-22 and are important in fighting infection but are also involved in mediating autoimmune disorders. (sciencemag.org)
  • IL17
  • Approved anti-IL17(R) drugs include : Brodalumab (Siliq), an antibody to the receptor, approved for psoriasis. (wikipedia.org)
  • rheumatoid arthritis
  • Chronic inflammation, or expression of these cytokines and receptors at low levels over long periods of time, promotes various pathological conditions including allergies and asthma, cardiovascular system disorders (atherosclerosis), central nervous system disorders (Alzheimer's disease), fibrosis, and rheumatoid arthritis. (qiagen.com)
  • vivo
  • 1 Soluble forms of these receptors are generated in vivo, either by proteolytic cleavage of their membrane forms or by alternative splicing, 2 and act as cytokine scavengers. (bmj.com)
  • molecular
  • The ability of OSM to signal via two receptor complexes conveniently offers a molecular explanation to the shared and unique effects of OSM with respect to LIF. (wikipedia.org)
  • CD40
  • Immunoglobulin (Ig) superfamily, which are ubiquitously present throughout several cells and tissues of the vertebrate body Tumor necrosis factor receptor family, whose members share a cysteine-rich common extracellular binding domain, and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF). (wikipedia.org)
  • inflammatory
  • These immune cells increase the expression of inflammatory cytokines that recruit additional immune cells. (qiagen.com)
  • The Human Inflammatory Cytokines & Chemokines Multi-Analyte ELISArray Kit analyzes a panel of 12 pro-inflammatory cytokines using a conventional ELISA protocol all at once under uniform. (qiagen.com)
  • PATHWAY
  • Like many cytokines OSM is produced from cells by de novo synthesis followed by release through the classical secretion pathway. (wikipedia.org)