• IL-27R deficiency during chronic Mtb infection does not impact antigen-specific CD4 + T cell number but maintains programmed death-1 (PD-1), CD69, and CD127 expression while reducing T-bet and killer cell lectin-like receptor G1 (KLRG1) expression. (rupress.org)
  • Sustained toll-like receptor 9 activation promotes systemic and cardiac inflammation, and aggravates diastolic heart failure in SERCA2a KO Mice. (uio.no)
  • Our results suggest that this distinctive combination of adhesion receptors helps form a unique lymphocyte-endothelial cascade that is important in lymphocyte subset recruitment to BALT and in bronchopulmonary immune responses. (rupress.org)
  • Antibodies to signaling molecules and receptors in Alzheimer's disease are associated with psychomotor slowing, depression, and poor visuospatial function. (uio.no)
  • Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 (англ. (wikipedia.org)
  • Mice lacking CXCR5 gene display defective primary follicles and germinal centers formation in the spleen and Peyer patches, and lack inguinal lymph nodes. (miltenyibiotec.com)
  • CXCR receptors isolated initially from BURKITT LYMPHOMA cells. (semanticscholar.org)
  • In the liver, after intrasplenic injection, these CXCR5 transfectants initially grew faster than controls, but the growth rate of control tumors accelerated later to become similar to the transfectants, likely due to the up-regulation of CXCR5. (ru.nl)
  • In contrast, s.c. and lung tumors of CXCR5- and intrakine-transfected cells grew at similar rates as controls. (ru.nl)
  • So far, there is very limited knowledge about the role of Eph kinases, the largest family of receptor tyrosine kinases, in the immune system. (jci.org)
  • Steroidal hormones influence morphology, physiology, and ultimately behavior from the cellular level to the organismal level through a variety of effectors, or classes of sex steroids, their specific receptor types, and several intracellular signaling pathways. (frontiersin.org)
  • To evaluate the role that CXCL13 and CXCR5 might play in AIDS-NHL, serum of individuals (n = 46) who ultimately developed AIDS-NHL was obtained from the Multicenter AIDS Cohort Study (MACS) at UCLA. (biomedcentral.com)
  • Inhibition of CXCR5 function, by trapping CXCR5 in the endoplasmic reticulum using a CXCL13-KDEL "intrakine," had no effect on initial growth of liver foci but later caused a prolonged growth arrest. (ru.nl)
  • A population of FOXP3+ regula-tory T cells that expresses CXCR5 and controls GC responses was recently described. (frontiersin.org)