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  • alternative complem
  • The SPR technique is particularly suitable for analysis of the alternative complement pathway (AP) because the inherent nature of the latter is to amplify deposition of C3b on various surfaces. (diva-portal.org)
  • inhibition
  • The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. (mybiosource.com)
  • Antigens
  • This year, a Nobel Prize went to the researchers who first began to describe how T cells recognize foreign antigens, and in a fitting complement, T cells also gave up their last great structural secret. (sciencemag.org)
  • pathway
  • Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection. (nih.gov)
  • Inhibitor
  • Clusterin: designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP-40 and testosterone-repressed prostate message 2 (TRPM2). (enjoypath.com)
  • molecules
  • In 1996, two independent groups managed to coax recalcitrant T cell receptor molecules to form crystals, allowing the first x-ray analysis of their 3D structure. (sciencemag.org)
  • And the teams captured the receptors in action-bound to their target molecules-offering new insight into how T cells learn to recognize their prey. (sciencemag.org)
  • immune
  • It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS. (wakehealth.edu)
  • pharmacological
  • 2. Using fast-perfusion patch clamp and single channel analysis, test combinations of construct modifications and pharmacological probes to stabilize distinct receptor conformations. (grantome.com)
  • Function
  • shRNA-resistant Akt wild-type constructs efficiently complemented the mitogenic signaling activity of E2 whereas constructs with inactivated kinase function did not. (beds.ac.uk)
  • interaction
  • The new x-ray data clinch many previous predictions about this complex interaction and shed new light on exactly how the receptor aligns with the MHC molecule. (sciencemag.org)
  • recognition
  • These eel-like fish use leucine-rich repeat-based receptors for Ag recognition instead of the Ig-based receptors used in jawed vertebrates. (jimmunol.org)
  • Instead of the Ig-based TCR, BCR, and Abs of jawed vertebrates, these jawless vertebrates use leucine-rich repeat sequences to assemble variable lymphocyte receptors (VLRs) for Ag recognition ( 1 , 2 ). (jimmunol.org)
  • cells
  • In growth factor-starved cells, the residual PI3K/Akt activity is sufficient to complement the mitogenic action of E2. (beds.ac.uk)