• BackgroundWe have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation. (edu.au)
  • Background MEDI-546 is an investigational human IgG1κ monoclonal antibody directed against subunit 1 of the type I interferon receptor (IFNAR1). (bmj.com)
  • This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. (wikipedia.org)
  • The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. (wikipedia.org)
  • The α2 subunit includes a domain homologous to von Willebrand factor domain binding to collagen. (wikipedia.org)
  • Collagens XIII, XVII, and XXV, and related proteins such as class A macrophage scavenger receptors, ectodysplasin A or the MARCO1 receptor, are also part of this group. (wikipedia.org)
  • Apart from having the characteristic structure of transmembranous collagens, all three proteins present a high level of amino acid residue conservation in collagenous and non-collagenous domains. (wikipedia.org)
  • A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. (wikipedia.org)
  • In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR), CD40, or CD19. (wikipedia.org)
  • It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. (wikipedia.org)
  • The receptor recognises terminal mannose, N-acetylglucosamine and fucose residues on glycans attached to proteins found on the surface of some microorganisms, playing a role in both the innate and adaptive immune systems. (wikipedia.org)
  • Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin fibroblasts. (docme.ru)
  • To determine the role of tumor necrosis factor receptor p55 (TNFRp55)-mediated signaling in the pathogenesis of scleroderma. (docme.ru)
  • It has been shown that in prostate collagen XXIII expression is associated with tumor progression. (wikipedia.org)
  • In this study we determined if low concentrations of TNF-alpha may inhibit the collagen phagocytic pathway in fibroblasts and thereby contribute to fibrosis. (semanticscholar.org)
  • When we inhibit this receptor in the mesenchymal stem cells, it tricks the cancer cells. (reliawire.com)
  • The structurally distinct inhibitors of PI 3-kinase, wortmannin, and LY294002, completely inhibit formation of phosphatidylinositol 3,4,5-trisphosphate by collagen. (ox.ac.uk)
  • Antiplatelet drugs like clopidogrel and prasugrel irreversibly inhibit the ADP receptor P2Y12, leading to a decreased ADP-induced platelet aggregation. (wikipedia.org)
  • Drugs that inhibit the GPIIb/IIIa receptor, e.g. eptifibatide, can also reduce or eliminate the ADP-induced platelet response. (wikipedia.org)
  • A T cell-associated protein index and a novel type III collagen turnover marker may serve as early response or predictive markers for type I IFN-targeted therapy in SSc subjects in future clinical trials. (bmj.com)
  • The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. (wikipedia.org)
  • Thrombin binding to its receptor activates protein kinase C and increases the level of inositol triphosphate. (wikipedia.org)
  • Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. (wikipedia.org)
  • Furthermore, cellular localization of collagen XXIII was determined by immunofluorescence staining, using an antibody that recognizes the carboxyl terminus of the protein. (wikipedia.org)
  • An alternative name for this type of protein is MACITs (membrane-associated collagens with interrupted triple helices). (wikipedia.org)
  • SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. (wikipedia.org)
  • Collagen alpha-1(XI) chain is a protein that in humans is encoded by the COL11A1 gene. (wikipedia.org)
  • Molecular characterization of CD93 revealed that this protein is identical with C1qRp, a human protein identified as a putative C1q receptor. (wikipedia.org)
  • The protein itself belongs to the class B scavenger receptor family which includes receptors for selective cholesteryl ester uptake, scavenger receptor class B type I (SR-BI) and lysosomal integral membrane protein II (LIMP-II). (wikipedia.org)
  • CD36 interacts with a number of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, platelet-agglutinating protein p37, oxidized low density lipoprotein and long-chain fatty acids. (wikipedia.org)
  • The protein encoded by this gene is phosphorylated by ZAP70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. (wikipedia.org)
  • Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes. (uzh.ch)
  • Loss of DDR1-expression in the kidney delayed renal fibrosis and inflammation in hereditary type IV collagen disease. (uzh.ch)
  • Biochemical and genetic studies indicate that the type IIB low-affinity receptor for immunoglobulin (Ig)G (FcγRIIB) inhibits cellular activation triggered through antibody or immune complexes and may be an important component in preventing the emergence of autoimmunity. (rupress.org)
  • Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptake. (receptome.org)
  • Conclusion: To the best of our knowledge, this study provides the first evidence that brazilin acts a novel collagen receptor agonist. (archive.org)
  • Background It has previously been shown that dual activation of the Liver X Receptors (LXRα and LXRβ) by the agonist, GW3965, enhances pathology in a murine model of collagen-induced arthritis. (bmj.com)
  • AR-R17779 is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors. (wikipedia.org)
  • 16 Whether collagen genes are also differentially affected by TGF-β 1 or the other two isoforms in VSMCs of SHR and WKY is not known. (ahajournals.org)
  • The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages and immature dendritic cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. (wikipedia.org)
  • The mannose receptor is the only member of the family in which this domain is functional. (wikipedia.org)
  • The fibronectin type II repeat domain is conserved amongst all members of the mannose receptor family. (wikipedia.org)
  • Through this domain, the mannose receptor internalises collagen in macrophages and liver sinusoidal cells, independent of the lectin activity of the receptor. (wikipedia.org)
  • Despite the similarities in mannose-binding between the mannose receptor and MBL, these differences suggest that mannose-binding by the mannose receptor evolved separately to that of other C-type lectins. (wikipedia.org)
  • It has been suggested that the mannose receptor can exist in at least two different structural conformations. (wikipedia.org)
  • This review summarizes the most important structural and functional properties of these adhesion receptors and briefly discusses their potential as targets for antithrombotic therapy. (ahajournals.org)
  • Mesenchymal cell types such as fibroblasts, osteoblasts, some endothelial cells, and some macrophages express uPARAP/Endo180, with a strong expression in areas with dominant collagen turnover, such as developing bone. (springer.com)
  • Objectives The sympathetic nervous system (SNS) as well as the interleukin (IL)-7/IL-7 receptor (IL-7R) system play a role in the pathogenesis of arthritis. (bmj.com)