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  • lipoprotein
  • Combined fat accumulation and formation of oxidized low-density lipoprotein (oxLDL) activate TLR2 receptor through the binding of oxLDL to CD36, and triggers the disproportional recruitment of pro-inflammatory macrophages causing the inflammation. (mitacs.ca)
  • The Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal with familial hypercholesterolemia, produces a mutant receptor for plasma low-density lipoprotein (LDL) that is not transported to the cell surface at a normal rate. (sciencemag.org)
  • inhibition
  • Type-B γ-aminobutyric acid receptors (GABABRs) are important for mediating slow inhibition in the central nervous system and the kinetics of their internalisation and lateral mobility will be a major determinant of their signalling efficacy. (bl.uk)
  • In conclusion, this study provides new and important insight into the mobility of cell surface GABABRs and the underlying mechanisms that ensure they provide efficacious slow synaptic inhibition. (bl.uk)
  • The efficacy of fast synaptic inhibition is critically dependent on the accumulation of GABA A receptors at inhibitory synapses, a process that remains poorly understood. (jneurosci.org)
  • GABA A receptors (GABA A Rs) are pentameric hetero-oligomers that mediate the majority of fast synaptic inhibition in the brain. (jneurosci.org)
  • EGFR
  • A clinical study in non-small cell lung cancer patients demonstrated a positive correlation between EGFR expression levels and the therapeutic efficacy of the EGFR mAb cetuximab. (jimmunol.org)
  • In this study, BHK-21 cells were stably transfected to express different EGFR levels, which were quantified by immunofluorescence and immunohistochemistry and compared with EGFR levels of clinical non-small cell lung cancer samples. (jimmunol.org)
  • These cells were used to systematically investigate the impact of target Ag expression levels on Fab- or Fc-mediated MoAs of EGFR mAb. (jimmunol.org)
  • In comparison with ADCC by mononuclear cells, polymorphonuclear cell-mediated ADCC and complement-dependent cytotoxicity required higher EGFR expression levels and higher mAb concentrations to trigger significant tumor cell killing. (jimmunol.org)
  • This correlation between EGFR expression levels and Fc-mediated MoA was confirmed in an independent panel of human tumor cell lines carrying diverse genetic alterations. (jimmunol.org)
  • Furthermore, RNA interference-induced knockdown experiments reinforced the impact of EGFR expression on tumor cell killing by EGFR mAb. (jimmunol.org)
  • cellular
  • Fluorescence cell imaging can be used for disease diagnosis and cellular signal transduction. (spiedigitallibrary.org)
  • Using a metal nanoshell as molecular imaging agent, we develop a cellular model system to detect CXCR4 chemokine receptor on T-lymphatic cell surface. (spiedigitallibrary.org)
  • Fluorescence cell imaging shows great promise in disease diagnosis or in elucidating cellular signal transduction. (spiedigitallibrary.org)
  • 11 , 12 However, cell imaging is often problematic due to interference from cellular autofluorescence and intrinsic drawbacks from the conventional organic fluorophores in cell imaging. (spiedigitallibrary.org)
  • Cellular autofluorescence is fluorescence from the substrate other than the fluorophore of interest in cell imaging. (spiedigitallibrary.org)
  • Thus, it is almost impossible to distinguish the emission of fluorophores from cellular autofluorescence by spectroscopy in cell imaging. (spiedigitallibrary.org)
  • Cellular senescence refers to a state of irreversible growth arrest and altered function of normal somatic cells after a finite number of divisions . (fightaging.org)
  • Biochemistry
  • Tung, M.F. and McNamee, M.G., Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes, Biochemistry 26: 3871 (1986). (springer.com)
  • Synthesis and photochemistry of a new class of o-nitrobenzyl derivatives and their effects on receptor function, Biochemistry 25: 1799 (1986). (springer.com)
  • mutant
  • Here we use a temperature-sensitive mutant of dynamin (G273D) to control the subcellular localization of activated NGF receptors (Trks). (jneurosci.org)
  • This effect was inhibited by a dominant-negative mutant of Rab11, suggesting that CIN85 promoted recycling of TGF beta receptors. (diva-portal.org)
  • lateral
  • Finally, the lateral surface mobility of GABABRs was studied by extending the BBS-tagging method to single-particle tracking using quantum dots. (bl.uk)
  • Using fluorescence recovery after photobleaching (FRAP), our studies show that synaptic receptors have lower FRAP rates compared with extrasynaptic GABA A Rs, strongly suggesting lower rates of lateral mobility for synaptic receptors compared with their extrasynaptic counterparts under control conditions. (jneurosci.org)
  • tropism
  • KSHV has a broad cell tropism and the attachment and receptor engagement on target cells have an important role in determining the cell type-specific mode of entry. (mdpi.com)
  • pathways
  • Professionally designed pharmacology, molecular and cell biology signaling pathways slides and diagrams for scientists and researchers. (dmoztools.net)
  • neutrophils
  • In additionwe show that AGP?bound hydroxyeicasotetraenoic acids (HETEs) induce increasesin [Ca2+]i in neutrophils through binding to the leukotriene B4 receptor BLT2. (openthesis.org)
  • fails
  • However, it fails to justify cell-specific uptake of these nanosystems to senescent cells following intravenous or subcutaneous delivery. (fightaging.org)
  • A similar mutation, detected by S1 nuclease mapping of LDL receptor messenger RNA, occurred in a patient with familial hypercholesterolemia whose receptor also fails to be transported to the cell surface. (sciencemag.org)
  • formation
  • Together, our results reveal that synaptic and extrasynaptic GABA A Rs exhibit distinct cell surface dynamics and that gephyrin plays a critical role in reducing the mobility of GABA A R clusters, thereby promoting the formation of postsynaptic inhibitory specializations. (jneurosci.org)
  • target
  • They are covalently bound with anti-CXCR4 monoclonal antibodies for immunoreactions with the target sites of the CXCR4 receptors on the CEM-SS cells. (spiedigitallibrary.org)
  • The C -terminal domain of VacA plays a crucial role in receptor recognition on target cells. (mdpi.com)
  • In the paper I'll point out here, the cell surface receptor CD9 is used to target nanoparticles carrying a therapeutic payload into senescent cells . (fightaging.org)
  • They are applied to all cells and target senescence in the sense of preferentially activating inside senescent cells. (fightaging.org)
  • So it is interesting to see a group working on the more traditional method of steering delivery via cell surface markers, in order to place the therapeutic into the target cell population only, or at least to the greatest degree possible. (fightaging.org)
  • Rapid
  • Udgaonkar, J.A. and Hess, G.P., Acetylcholine receptor: Channel-opening kinetics evaluated by rapid chemical kinetic and single-channel current measurements, Biophys. (springer.com)