Receptors cell adhesion molecules neuronal. Medical search. Frequent questions

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. (antibodiesinc.com)
In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. (arigobio.com)
Nociceptive hypersensitivity results from activity of the N-methyl-D-aspartate receptor (NMDAR)-mediated glutamatergic synaptic transmission in the spinal cord and brain. (ochsnerjournal.org)
The evidence shows that in chronic pain conditions, peripheral sensory neurons and axons show synaptic remodeling in the spinal dorsal horn, resulting in nociceptive hypersensitivity that is dependent on the activity of the N-methyl-D-aspartate receptor (NMDAR). (ochsnerjournal.org)
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. (neurotree.org)
Neuronal excitation is also influenced by the amounts of neurotransmitter receptors and signaling molecules retained at particular synaptic sites. (frontiersin.org)
In this review we will highlight mechanisms that control targeting of PSD-95 at the synapse, and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic structure and strength. (frontiersin.org)
In the brain, they have well-described roles in slowly emerging, but long-lasting pathophysiological processes of cell loss and synaptic dysfunction associated with acute injury, ischaemia, neurodegeneration and demyelination. (nature.com)
In particular, widespread and protracted MMP activity can contribute to neuronal loss and synaptic dysfunction. (nature.com)
Recent studies have demonstrated that in addition to the PNS, endothelial cells in the CNS produce semaphorin 3G, which directly acts on neuropilin-2/PlexinA4 in neurons to regulate synaptic structure and plasticity [ 4 ]. (biomedcentral.com)
However, since previous studies mostly focused either on developing PNS or on adult CNS synaptic plasticity, the direct effect of vascular cell-secreted proteins on neuritogenesis in the very early stage of neuronal development is not well characterized. (biomedcentral.com)

Finally, we showed that BMAL1 contributes to AP-1 transcriptional control of key features of the senescence program, including altered regulation of cell survival pathways, and confers resistance to drug-induced apoptosis. (bvsalud.org)
Four of XLID- associated genes involved in neuronal signaling pathways are L1CAM, ZDHHC9, GLRA2 , and ATP2B3 . (biomedcentral.com)
4 , 5 Increased reactivity of pain-processing cells in the spinal cord or brain evokes hyperexcitability of pain pathways combined with decreased activity of inhibitory pathways. (ochsnerjournal.org)
This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)
Introduction to neuroinflammation - These lectures will provide a general introduction to neuroinflammation, including description of inflammatory mediators (cytokines, chemokines and adhesion molecules), mechanisms of production and action in the brain (receptors, signalling pathways and downstream effects) and cell-cell interactions. (manchester.ac.uk)
Altered signaling pathways in neuronal and glial cells (Garcia et al. (tam-receptor.com)
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. (kxcdn.com)
Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. (kxcdn.com)
Combined omics analyses of donor VSMC secretomes and recipient neuron transcriptomes revealed that overlapping pathways of extracellular matrix receptor signaling and adhesion molecule integrin binding mediate VSMC-dependent neuronal development. (biomedcentral.com)

The SR84 monoclonal antibody specifically recognizes CD49a (CD49 antigen-like family member A). CD49a is a ~200 kDa type I transmembrane molecule that is encoded by ITGA1 ( Integrin subunit alpha 1). (bdbiosciences.com)
Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. (antibodiesinc.com)
L1 is a transmembrane adhesion molecule with extracellular immunoglobulin and fibronection III-like domains ( Schachner, 1991 ). (jneurosci.org)
The L1CAM gene (MIM No. 308840) encodes a neural cell adhesion molecule involved in cell adhesion dynamics and the generation of transmembrane signals at tyrosine kinase receptors. (biomedcentral.com)
Protein tyrosine phosphatase receptor delta ( PTPRD ) is an important regulator of axon growth and guidance and is highly expressed in the central nervous system where it functions as a transmembrane homophilic neuronal cell adhesion molecule [ 1 ]. (biomedcentral.com)

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. The Journal of cell biology, 223-232. (antibodiesinc.com)
Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
PX inhibits the AChE within SH-SY5Y cells within a few minutes at sub-micromolar amounts but the lack of cell viability takes place at millimolar amounts (24-48 h) recommending deleterious biochemical systems which may Oxibendazole be downstream effects of AChE inhibition or may result from changes of proteins other than AChE (Ehrich et al. (tam-receptor.com)
All these events are primarily regulated by an array of regulatory proteins that are present on the cell surface, such as ion channels, receptors and adhesion molecules which sense the different chemical signaling cues and allow the neurons to respond accordingly [ 8-10 ]. (silverchair.com)
At the Ipsen Foundation's 23rd Colloquium on Alzheimer's Disease, held 28 April 2008 in Paris, the focus shifted from the rogue proteins that characterize these diseases to the regulation of their movements around the cell. (alzforum.org)
There is also traffic in the opposite direction: molecules are transported into the cell from outside, including worn-out or excess receptor and channel proteins from the outside of the cell membrane. (alzforum.org)
The details of how proteins are moved around within a cell are being deciphered with high-powered microscopy combined with sophisticated techniques for labeling individual molecules, including fluorescent or "quantum dot" tags and antibodies tailored to adhere to a protein in a particular state of activation. (alzforum.org)
These painstaking methods are now being applied to investigating how molecules are moved around in neurons and how the proteins that characterize neurodegenerative diseases may disrupt one or more of these mechanisms. (alzforum.org)
Both the EGFR and the DAT proteins have sites to which the molecule ubiquitin-best known as labeling a protein for degradation-can attach. (alzforum.org)
In summary, the detection of neurofilament proteins and synaptophysin and the absence of glial fibrillary acidic protein provide strong evidence for a neuronal phenotype of D384 Med, D425 Med, and D458 Med. (duke.edu)
Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells. (kyoto-u.ac.jp)
Intercellular communication between vascular and nerve cells mediated by diffusible proteins has recently emerged as a critical intrinsic program for neural development. (biomedcentral.com)
In particular, it is unknown whether cerebral arteriolar smooth mural cell-secreted proteins act directly on neurons and accelerate neuron maturation at transcriptomic level, neuronal survival, and circuit development. (biomedcentral.com)

Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. (wikipedia.org)
Many of these PSA-NCAM immunoreactive cells also express doublecortin, a molecule involved in neuronal migration. (nih.gov)
These results expand the current knowledge of the neuronal populations expressing PSA-NCAM in the piriform cortex, suggesting that some of these cells could be involved in structural plastic events such as axonal outgrowth, synaptogenesis or even neuronal migration. (nih.gov)
In these patients, GnRH deficiency and anosmia are believed to be secondary to abnormalities of neuronal migration during development. (medscape.com)
This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. (arigobio.com)
Trans-well assay evaluating migration of rat bone marrow mesenchymal stem cells after MicroRNA124 and microRNA21-5p overexpression. (silverchair.com)
discuss how microRNA124 and microRNA21-5p regulate migration, proliferation and differentiation of rat bone marrow mesenchymal stem cells. (silverchair.com)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)
Cell migration is negatively modulated by ABCA1. (kyoto-u.ac.jp)
Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)

Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)
L1 has been localized to growth cones and processes of postmitotic developing neurons, where it mediates cell adhesion, neurite outgrowth, and axon bundling. (jneurosci.org)
Neuronal connections are made with exquisite accuracy between specific types of neurons. (stanford.edu)
Since the piriform cortex is also populated by PSA-NCAM immunoreactive neurons during adulthood, we sought to characterize them in detail and to test whether NMDA receptor antagonists also modulate PSA-NCAM in this cortical region. (nih.gov)
These putative migratory cells and some neurogliaform neurons in layer II do not express NeuN, a marker of differentiated neurons. (nih.gov)
The number of PSA-NCAM immunoreactive neurogliaform neurons increases significantly 7 days after the administration of an NMDA receptor antagonist. (nih.gov)
We have investigated Aplysia hemolymph as a source of endogenous factors to promote regeneration of bag cell neurons. (nature.com)
Enhanced regeneration of dissociated bag cell neurons was observed in the presence of central nervous system (CNS) sheath cells or arterial cells 12 , or material remaining after such cells were killed 13 . (nature.com)

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. (sigmaaldrich.com)
Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)

Administration of NMDA receptor antagonists upregulates the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) in the adult hippocampus. (nih.gov)
There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. (cusabio.com)

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. (wikipedia.org)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)

Each of the cell lines also reacted with antibodies against neural cell adhesion molecules, but none of them were positive for antibodies against glial fibrillary acidic protein, keratin, microtubule-associated protein tau and microtubule-associated protein 2, human lymphocyte antigen-DR, epidermal growth factor receptor, and T-cell antigen. (duke.edu)

Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD , indicating a potential tumor suppressor function for this gene. (biomedcentral.com)
Neuroblastoma is derived from primitive cells of the sympathetic nervous system, and is the most common extracranial solid tumor in children accounting for 15% of all childhood cancer deaths [ 13 ]. (biomedcentral.com)
Several evidences demonstrated that DNAM-1 is involved in NK and T cell-mediated cytotoxicity (CTL) against ligand-expressing tumor cells. (biolegend.com)
Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)

Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. (bvsalud.org)
Receptor, Fibroblast Growth Factor, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Receptor, Fibroblast Growth Factor, Type 1" by people in this website by year, and whether "Receptor, Fibroblast Growth Factor, Type 1" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Receptor, Fibroblast Growth Factor, Type 1" by people in Profiles. (uchicago.edu)
SWOG S1400D (NCT02965378), a Phase II Study of the Fibroblast Growth Factor Receptor Inhibitor AZD4547 in Previously Treated Patients With Fibroblast Growth Factor Pathway-Activated Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). (uchicago.edu)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 4 ] Of note, anosmin may enhance fibroblast growth factor signaling through the fibroblast growth factor receptor 1. (medscape.com)

Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. (cusabio.com)
The differences in the characteristics between the murine model and humans are the host receptor and the absence of knob-like structures of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) (Table 2 ) [ 11 ]. (biomedcentral.com)
The tubules are all made of the same water-repellant fatty membrane that surrounds the cell, separating their interior from the watery cytoplasm. (alzforum.org)
Many are taken in by endocytosis, sinking into pits in the membrane that pinch off to form vesicles that drop into the cell, where they are known as early endosomes. (alzforum.org)
Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. (kxcdn.com)
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (kxcdn.com)

LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. (sigmaaldrich.com)
Additionally, DNAM-1 regulates monocyte extravasation through PVR expressed by endothelial cells. (biolegend.com)
They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)
Endothelial cells in the inner layer and mural smooth muscle cells (SMCs) or mural pericytes in the outer layer constitute the major building blocks for the entire cerebral vasculature, with SMCs enveloping arteries and arterioles and pericytes covering capillaries. (biomedcentral.com)

Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. (kxcdn.com)

The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)

The mechanisms of neurovascular unit dysfunction, neuronal plasticity, glial scar, neurogenesis and angiogenesis will be addressed. (manchester.ac.uk)
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)

Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. (biomedcentral.com)
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. (neurotree.org)
This process is thought to be regulated by molecules that regulate synapse number, morphology and strength. (frontiersin.org)
As in a petrochemical plant, different steps in the production process take place in dedicated compartments, and signaling systems regulate the movement of molecules between compartments. (alzforum.org)
However, Sigma1R receptors regulate cognitive processes under disturbed neurotransmitter balance only. (epiphanyasd.com)

In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions. (embl.de)
It is involved in mediating cell-cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. (antibodiesinc.com)
A true amount of research have got examined the interactions between OPs and cell lines. (tam-receptor.com)
Several Ig-superfamily CADMs are crucial for immune cell interactions. (pharmiweb.com)
Receptor mobility and receptor-cytoplasmic interactions in lymphocytes. (academicinfluence.com)
Microelectrode cluster technology for precise interactions with neuronal circuits. (lu.se)

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)

Upon induction of LTP, but not other forms of short- or long-lasting plasticity, pro-MMPs are rapidly (within ∼ 15 min) converted to proteolytically active MMPs through an NMDA receptor-dependent mechanism. (nature.com)
These findings are relevant to understand the sprouting of new neurites, neuroregeneration and neuronal plasticity at the cellular, subcellular and molecular levels. (silverchair.com)

Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. (kxcdn.com)
However, whether the vascular smooth muscle cell (VSMC) secretome regulates the connectivity of neural circuits remains unknown. (biomedcentral.com)

Dysregulation of these molecules can lead to various diseases, including cancer metastasis, autoimmune disorders, and developmental abnormalities. (pharmiweb.com)

Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (academicinfluence.com)

A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. (wikipedia.org)
MAM is an acronym derived from meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu. (embl.de)

Both molecules support neurite outgrowth from several neuronal cell types when presented as uniform substrates. (researchgate.net)

Antibody blocking assay demonstrated that DNAM-1 may play a role in polarization of T cells, activation and effectors of Th1 cells. (biolegend.com)
Edelman's Nobel Prize-winning research concerned discovery of the structure of antibody molecules. (academicinfluence.com)

Apical endosomal glycoprotein from rat, a protein probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. (embl.de)
Two ligands for DNAM-1 have been identified, the poliovirus receptor (PVR/CD155) and its family member nectin-2 (PRR/CD112), which are located at cell junctions and broadly expressed on epithelial, endothelial and neuronal cells. (biolegend.com)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
Although these receptors are structurally similar, they determine specificity for four ligands-GDNF, Neurturin (NRTN), Artemin (ARTN) and Persephin (PSPN). (medsci.org)
Transformation of ESR into the cell stress augments reception in the domain responsible for binding the endo- and exogenous ligands of sigma 1 receptor chaperon protein (Sigma1R) [1] responsible for adaptive reactions [8]. (epiphanyasd.com)

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule. (academicinfluence.com)

Virus-mediated gene therapy has the potential to deliver exogenous genetic material into specific cell types to promote survival and counteract disease. (frontiersin.org)
Gene therapy viruses are non-replicating, but still hijack host cell machinery to express transgenes of interest in the nucleus. (frontiersin.org)
Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene. (wikipedia.org)
Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. (wikipedia.org)
We found that LGR5 expression in intestinal crypt cells is controlled by the circadian core clock gene BMAL1 and the BMAL1-regulated RNA-binding protein MEX3A. (bvsalud.org)
In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. (gsea-msigdb.org)
In this research HSG cells had been subjected to paraoxon (System 1) and choose cytotoxic assays had been executed and validated by gene appearance adjustments to assess toxicity caused by low-level publicity. (tam-receptor.com)
[ 11 ] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
Homozygous mutations in GPR54, a gene encoding a G protein-coupled receptor, which binds kisspeptin 1, have been reported as a cause of hypogonadotropic hypogonadism. (medscape.com)

For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell interaction and internalization, intracellular sorting, long-range retrograde axonal transport, endosomal liberation, and nuclear import. (frontiersin.org)
Similar to the hippocampus, NMDA receptors appear to play a critical role in these processes in the adult piriform cortex. (nih.gov)
This shift comes with the growing realization that neurodegeneration is less a problem of toxic molecules per se but rather of the way these molecules disrupt the basic biological processes of the cell-their effects on the cell as a system. (alzforum.org)
But, unlike in the production line of a manufacturing plant, the cell may be making many different molecules at the same time, so labels and locations are needed to separate out these simultaneous processes. (alzforum.org)
Cell adhesion and the molecular processes of morphogenesis. (academicinfluence.com)

Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. (bvsalud.org)
Aberrant splicing of the 5' UTR also has been noted in neuroblastoma cell lines and primary tumors, which could potentially cause destabilization of the mRNA sequence [ 10 ]. (biomedcentral.com)
In the cerebellar cortex, tenascin-C mRNA in Golgi epithelial cells was down-regulated 3 days after the lesion and returned to control values 80 days after the lesion. (researchgate.net)
Tenascin-R mRNA was expressed by distinct neural cell types in the unlesioned olivocerebellar system. (researchgate.net)
tein, and neuronal cell adhesion molecule mRNA were also increased in olfactory bulb. (cdc.gov)

This cell surface glycoprotein contains a zinc-metalloprotease domain capable of degrading a variety of polypeptides. (embl.de)
The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)
IMPORTANCE: Understanding how viruses interact with the host cell surface and reach the intracellular space is of crucial importance for applied and fundamental virology. (cnrs.fr)
DNAM-1 is predominantly expressed on cell surface of T cells, NK cells, monocytes/ macrophages, platelets and megakaryocytes and a subset of B cells. (biolegend.com)
Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (tam-receptor.com)
It inactivates the receptors that respond to the signal, or the transporter molecules that suck up the signal chemical by removing them from the cell surface. (alzforum.org)
Surface modulation in cell recognition and cell growth. (academicinfluence.com)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

These molecules are essential for embryonic development, wound healing, immune cell recognition, and many other physiological functions. (pharmiweb.com)
Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. (academicinfluence.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Scholars@Duke publication: Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. (duke.edu)

Rapidly proliferating LGR5+ crypt base columnar (CBC) cells are responsible for epithelial turnover needed to maintain intestinal homeostasis. (bvsalud.org)
Together, these findings reveal a BMAL1-centered intrinsic regulatory pathway that maintains LGR5 expression in the crypt cells and suggest a potential mechanism contributing to ISC homeostasis. (bvsalud.org)
Homeostasis is a form of regulation of neuronal excitability that maintains system function at a set point, maintaining a constant output while exposed to changing inputs. (frontiersin.org)
Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. (kxcdn.com)

displays a reduced size of the corticospinal tract and decreased axonal association with nonmyelinating Schwann cells. (jneurosci.org)

The HSG cell series was produced from isolated epithelial cells in the irradiated submandibular salivary gland of the squamous cell carcinoma. (tam-receptor.com)

It is expressed on activated T cells, monocytes, neuronal cells and smooth muscle cells. (bdbiosciences.com)

CD49a is also known as very late antigen 1α subunit (VLA-1) of the integrin family of cell adhesion molecules. (bdbiosciences.com)
CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. (bdbiosciences.com)
Here, we show that in fibroblast-like cells, the CAR ICD is needed for FKCAV entry and efficient CAV-2 transduction, but dispensable for HAdV-C5 and a HAdV-C5 capsid lacking the RGD sequence (an integrin-interacting motif) in the penton. (cnrs.fr)
Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. (kxcdn.com)

Antigen binds to IgE that is bound to tissue mast cells and blood basophils, triggering release of preformed mediators (eg, histamine, proteases, chemotactic factors) and synthesis of other mediators (eg, prostaglandins, leukotrienes, platelet-activating factor, cytokines). (msdmanuals.com)

By the end of the Lecture core, interns are introduced to lab demonstrations for the techniques and methodologies utilized in each Research Module: Behavioral, Functional, Cell Biology (or Cellular) and Genomic. (reachsummerprogram.com)
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. (cusabio.com)

ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. (sigmaaldrich.com)

The understanding of molecules and their role in neurite initiation and/or extension is not only helpful to prevent different neurodegenerative diseases but also can be important in neuronal damage repair. (silverchair.com)
Ectopic expression of TRPV2-GFP in F11 cell induces more primary and secondary neurites, confirming its role in neurite initiation, extension and branching events. (silverchair.com)
Furthermore, we found that human arterial VSMCs promote neuronal development in multiple ways, including expanding the time window for nascent neurite initiation, increasing neuronal density, and promoting synchronized firing, whereas human umbilical vein VSMCs lack this capability. (biomedcentral.com)
Neurite initiation, termed neuritogenesis, is the foremost event of neuronal morphogenesis [ 8 ]. (biomedcentral.com)

Recent studies revealed a key role for PSD- 95, a scaffolding molecule enriched at glutamatergic synapses, in modulation of clustering of several neurotransmitter receptors, adhesion molecules, ion channels, cytoskeletal elements and signaling molecules at postsynaptic sites. (frontiersin.org)

Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that function during the formation of certain neuronal circuits. (embl.de)
DNAM-1, also known as CD226, was first identified as T lineage-specific activation antigen (TLiSA) and subsequently renamed as Platelet and T-cell activation antigen 1 (PTA). (biolegend.com)
CD22 antigen is present in the most B-cell leukemias and lymphomas but not T-cell leukemias. (tam-receptor.com)
In contrast with CD10, CD19 and CD20 antigen, CD22 antigen is still present on lymphoplasmacytoid cells but is dininished on the fully mature plasma cells. (tam-receptor.com)
Anti-human lymphocyte antigen-A,B and anti-beta 2-microglobulin antibodies reacted with xenografts of D384 Med and D425 Med and were weakly positive for a small population of D384 Med cultured cells. (duke.edu)

In this report, we demonstrate for the first time that experimental up-regulation of PTPRD in neuroblastoma cell lines significantly decreases cell growth and increases apoptosis. (biomedcentral.com)
14] Kisspeptin 1 and its receptor have an important role in the regulation of GnRH and the onset of puberty. (medscape.com)
Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. (kxcdn.com)
It cannot be excluded that the anxiolytic effect of Afobazole is accompanied by up-regulation of Sigma1R chaperone functions, because this drug normalizes the stress-induced down-regulation of reception in benzodiazepine site of GABAA receptor [6]. (epiphanyasd.com)
Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)

For example, inflammatory factor CCL2, toll like receptors TLR2 and TLR4, proinflammatory cytokines IL-6, IL-11 and IL1rn which were activated after TBI and were decreased by NMN treatment. (medsci.org)
You will gain an understanding of the important role of inflammatory molecules as key mediators of central nervous system (CNS) functions and of inflammatory responses to, and pathogenesis of, acute and chronic nervous system disorders. (manchester.ac.uk)
This unit will cover the important role of inflammatory molecules as key mediators of CNS functions and will provide basic knowledge on the pathogenesis of, and inflammatory responses to acute and chronic nervous system disorders. (manchester.ac.uk)
These mediators cause vasodilation, increased capillary permeability, mucus hypersecretion, smooth muscle spasm, and tissue infiltration with eosinophils, type 2 helper T (TH2) cells, and other inflammatory cells. (msdmanuals.com)

Here, we show that conditioned medium from brain VSMC cultures enhances multiple neuronal functions, such as neuritogenesis, neuronal maturation, and survival, thereby improving circuit connectivity. (biomedcentral.com)
Here, we showed that the secretomes obtained from primary mouse cerebral vascular SMCs, a human brain SMC cell line, and a human aorta SMC cell line promote neuronal early morphogenesis, functional maturation, and survival in vitro. (biomedcentral.com)

TRPV2-mediated neuritogenesis is dependent on wildtype TRPV2 as cells expressing TRPV2 mutants reveal no neuritogenesis. (silverchair.com)
Neuritogenesis is a complex process by which new neurites originate from cell body followed by a series of stochastic events such as neurite extension and/or retraction, bending and often branching at certain points [ 2 , 7 , 8 ]. (silverchair.com)
However, the direct impacts of the secretome of vascular cells on neuritogenesis, neuronal survival, and functional circuitry establishment remain largely unknown. (biomedcentral.com)

In humans, mutations in the L1 cell adhesion molecule are associated with a neurological syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation, adducted thumbs, spasticity, and hydrocephalus. (jneurosci.org)
[ 7 ] Homozygous, heterozygous or compound heterozygous mutations of the prokineticin receptor 2 have also been associated with Kallmann syndrome. (medscape.com)
[ 8 ] Digenic inheritance has been suggested in an individual carrying heterozygous mutations of prokineticin receptor 2 and KAL1 . (medscape.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)

For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer. (uchicago.edu)

Spike-timing dynamics of neuronal groups. (academicinfluence.com)

Con respecto a los modelos animales en TEA, muchos estudios se centran en la expresión génica, la migración y maduración neuronal cortical y los déficits de la red neuronal, pero muy pocos son los estudios que relacionen directamente la comunicación oral animal y la expresión génica en áreas corticales del lenguaje. (bvsalud.org)

This is particularly enticing for neuronal conditions, as the nervous system is renowned for its intransigence to therapeutic targeting. (frontiersin.org)
CD49a has been reported to play a role in cell attachment during the development of both the central and peripheral nervous systems. (bdbiosciences.com)
To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)

When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)

Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. (kxcdn.com)
They focus on Sigma1-R receptors modulating NMDA-based neurotransmission, but there seem to many possible further effects within the Endoplasmic Reticulum that relate specifically to autism. (epiphanyasd.com)

onasemnogene abeparvovec marketed as Zolgenmsa), as well as non-neuronal conditions ( High and Roncarolo, 2019 ). (frontiersin.org)

Our proposed pathway of CAV-2 entry is in contrast to that of human AdV type 5 (HAdV-C5) in non-neuronal cells, where internalization is mediated by auxiliary receptors such as integrins. (cnrs.fr)
We therefore asked if in fibroblast-like cells the intracellular domain (ICD) of CAR plays a role in the internalization of the CAV-2 fiber knob (FKCAV), CAV-2, or HAdV-C5 when the capsid cannot engage integrins. (cnrs.fr)
Here, we compare the role of a cell adhesion molecule (CAR), in the internalization of adenoviruses that naturally infect humans and Canidae. (cnrs.fr)

When offered as a sharp boundary with a permissive substrate, however, both molecules prevent neurite elongation. (researchgate.net)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)

A large cluster of Sigma1R receptor was revealed in the hippocampus that plays a key role in adaptive behavior related to building of spatial cognitive maps, learning, and memory. (epiphanyasd.com)

C-C motif chemokine receptor 7 [So. (gsea-msigdb.org)

It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)

Part of this work was presented at the 40th Annual Meeting of the American Society for Cell Biology, San Francisco, CA, 9-13 December 2000 (Strochlic, L., A. Cartaud, V. Labas, W. Hoch, J. Rossier, and J. Cartaud. (rupress.org)

Anatomy55

Organisms17

Diseases3

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology4

Phenomena and Processes51

Disciplines and Occupations2

Information Science3

Health Care1

Synaptic11

Pathways9

Transmembrane5

Proteins17

Migration12

Neurons9

Intercellular3

NCAM2

Encodes2

Epidermal growth f1

Tumor6

Fibroblast Growth7

Membrane7

Endothelial cells6

Leukocyte1

Extracellular matrix1

Glial3

Regulate5

Interactions6

Neural cell adhe1

Plasticity2

Regulates2

Abnormalities1

Immunoglobulin2

Protein tyrosine ph2

Outgrowth1

Antibody2

Ligands5

Homophilic1

Gene10

Processes5

MRNA5

Surface9

Embryonic3

Differentiation2

Homeostasis4

Axonal1

Epithelial cells1

Monocytes1

Integrin4

Binds1

Cellular2

Lymphocytes1

Neurite initiation4

Cytoskeletal1

Antigen5

Regulation5

Inflammatory4

Maturation2

Neuritogenesis3

Mutations4

Neurotrophin1

Estrogen Receptor1

Dynamics1

Cortical1

Nervous4

Downstream1

NMDA2

20191

Internalization3

Substrate1

19831

Superfamily1

Hippocampus1

Chemokine1

Glutamatergic1

20001