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  • antagonists
  • 4 5 Owing to its prominent role in HIV-1 pathogenesis, CCR5 has become a focus of investigation concerning its regulation and the development of antagonists that may interrupt the interaction between HIV-1-envelope and CCR5. (bloodjournal.org)
  • Co-culture with CCR5 Mouse monoclonal to EphB3 antagonists (= 10) and (= 9) inhibited the introduction of intimal thickening ( 0.05, Friedman test accompanied by Dunn's multiple comparison test). (sunolmolecular.com)
  • KINASE
  • In this study, it is shown that a classic chemotactic factor, the bacterial chemotactic peptide N-formyl-methionyl-leucylphenyl-alanine (fMLF), rapidly induced a protein-kinase-C-mediated serine phosphorylation and down-regulation of the chemokine receptor CCR5, which serves as a major human immunodeficiency virus (HIV)-1 coreceptor. (bloodjournal.org)
  • protein
  • The Hill slope was 1.14 0.06 having a receptor denseness of 22 9 fmol mg?1 protein. (sunolmolecular.com)
  • The present study was undertaken to determine whether these two structurally and functionally distinct G-protein-coupled receptors are in close proximity and form an oligomeric complex in the cell membrane so that the activation of one triggers the activity of the other. (uniprot.org)
  • It is a seven-transmembrane G-protein-coupled receptor on the surface of leukocytes. (biology-online.org)
  • therapeutic
  • We applied the GEnSeMBLE methodology to predict this ensemble, and we designed and carried out 11 experiments to validate the ability of this ensemble to predict binding of an HIV therapeutic to CCR5. (pnas.org)
  • experiments
  • Immunoprecipitation experiments showed that CCR5, but not CD4 nor Na(+)/H(+) exchanger, coprecipitates with all three subtypes (mu, delta, and kappa) of opioid receptors. (uniprot.org)