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Receptors, CCR5Receptors, CCR2Receptors, CCR1Receptors, CCR7Receptors, CCR3Receptors, CCR4Receptors, CCR6Receptors, ChemokineReceptors, CCR8Receptors, CCRChemokines, CCReceptors, CCR10Chemokine CCL19Chemokine CCL21Chemokine CCL5Macrophage Inflammatory ProteinsChemokine CCL20Chemokine CCL17Chemokine CCL1Chemotaxis, LeukocyteChemokinesChemokine CCL4Chemokine CCL2Chemokine CCL22Chemokine CCL11Receptors, CXCR4Receptors, CXCR3Receptors, HIVChemotaxisChemokine CCL3Chemokine CCL24Receptors, CytokineCell MovementMonocyte Chemoattractant ProteinsHIV-1MonocytesMice, KnockoutMice, Inbred C57BLCD4-Positive T-LymphocytesFlow CytometryChemokine CCL8Chemokine CCL7T-LymphocytesDendritic CellsCells, CulturedLigandsChemotactic Factors, EosinophilMacrophagesChemokines, CXCHIV Envelope Protein gp120Hypoglossal Nerve InjuriesAntigens, CD4RNA, MessengerTranscellular Cell MigrationCytokinesT-Lymphocyte SubsetsMice, Inbred BALB CReceptors, Lymphocyte HomingCell LineLymph NodesTh2 CellsLymphoid TissueImmunologic MemoryReceptors, Interleukin-8BChemokine CXCL12Th1 CellsUp-RegulationAntigens, CD11bLeukocytesMolecular Sequence DataReverse Transcriptase Polymerase Chain ReactionSignal TransductionReceptors, Interleukin-8ACD8-Positive T-LymphocytesAdoptive TransferGene Expression RegulationEosinophilsHIV InfectionsSkinLeukocytes, MononuclearLymphocyte ActivationAmino Acid SequenceInflammationQuaternary Ammonium CompoundsThymus GlandAmidesbeta-DefensinsDisease Models, AnimalImmunophenotypingL-SelectinDown-RegulationIntegrin alpha4Acquired Immunodeficiency SyndromeProtein BindingImmunohistochemistryGene ExpressionCHO CellsTransfectionInterleukin-4Cell Differentiation
ChemokinesCCR5CCR2Monoclonal antibodyCCL22BindsCCR10LigandsChemoattractantCCR3Chimeric Antigen ReceptorMacrophagesCCR1MotifAntagonistAntigenCXCR3CytokineLymphocytesSeven transmembraneCD194CellsSubunitSignaling moleculesTumorProteinPeripheral bloodTregsCellTissuesRPT193HumanSignalsSubunitsGenesTypeCX3CR1PhosphorylationBindEosinophilsPotentInflammation
Chemokines12
  • It is a receptor for the following CC chemokines: CCL2 (MCP-1) CCL4 (MIP-1) CCL5 (RANTES) CCL17 (TARC) CCL22 (Macrophage-derived chemokine) Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. (wikipedia.org)
  • We have provided evidence that polarization of T(H)2-type chemokine receptors on IL-4-expressing cells can be demonstrated in an in vivo setting and therefore that these cells might indeed be susceptible to differential patterns of recruitment as a result of expression of the relevant chemokines at inflammatory sites. (nih.gov)
  • Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
  • Use this table to quickly identify the chemokines that bind to each receptor. (biolegend.com)
  • This process is mediated by chemokines, which guide cell migration by binding to their specific receptors. (confex.com)
  • Receptors such as CCR4 bind to chemoattractant molecules called chemokines that orchestrate migration and homing of immune cells to specific tissues throughout the body. (cafepharma.com)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
  • High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. (icr.ac.uk)
  • Mogamulizumab-kpkc is a defucosylated, humanized IgG1 kappa monoclonal antibody that binds to CCR4, a G protein-coupled receptor for CC chemokines that is involved in the trafficking of lymphocytes to various organs. (mdtodate.com)
CCR59
  • Interestingly, receptors which expression declines during NK cell differentiation (CCR5, CCR7, and CXCR3) are commonly associated with adaptive T cell responses to viruses, whereas receptors that are upregulated along the differentiation axis (CXCR1, CXCR2, CX3CR1, CMKLR1) are typical for neutrophils and macrophages as a part of the innate immune response. (confex.com)
  • May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. (qedbio.com)
  • We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
  • The receptors are widely distributed on homozygous for the CCR5 32 bp deletion. (cdc.gov)
  • Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
  • The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • In addition, peripheral blood CD4(+) T-cell phenotype and activation status were evaluated by flow cytometry before treatment and at 2, 4, and 12 weeks using CD69, chemokine receptor (CCR4, CCR5, and CXCR3), and intracellular cytokine (tumor necrosis factor alpha, interferon-gamma, and interleukin 10) expression. (bvsalud.org)
CCR25
Monoclonal antibody4
  • Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL. (wikipedia.org)
  • POTELIGEO is a CC chemokine receptor type 4 (CCR4)-directed monoclonal antibody indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy ( 1 ). (nih.gov)
  • Mogamulizumab-kpkc (Poteligeo®) is a CC chemokine receptor type 4 (CCR4)-directed monoclonal antibody. (wellcare.com)
  • Mogamulizumab-kpkc is a recombinant humanized monoclonal antibody that targets CC chemokine receptor 4 (CCR4)-expressing cells. (mdtodate.com)
CCL223
  • These cells are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor and its ligand CCL22 (5). (biolegend.com)
  • CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases. (biolegend.com)
  • Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4 + Treg axis during remission of crescentic glomerulonephritis. (peprotech.com)
Binds1
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
CCR102
  • CCR4 and CCR10 play an important role in the ligand-mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site of injury (2,3). (biolegend.com)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
Ligands1
Chemoattractant1
  • Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. (icr.ac.uk)
CCR31
Chimeric Antigen Receptor1
  • Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
Macrophages3
  • The CCL17-CCR4 axis between endometrial stromal cells and macrophages contributes to the high levels of IL-6 in ectopic milieu. (endometriosi.it)
  • IL-6 induced CCL17 secretion in ESCs via activating JNK signaling pathway, CCL17 upregulated the expression of its receptor CCR4 on macrophages. (endometriosi.it)
  • Furthermore, CCL17-CCR4 axis subsequently led to excessive IL-6 production in macrophages by activating NF-κB. (endometriosi.it)
CCR11
  • Interestingly, CCR1 and CXCR6 were expressed mainly on less differentiated NKG2A+ CD56dim NK cells (B). Next, we stratified the chemokine receptor expression on mature KIR+ NK cells based on the expression of self (educated) or non-self KIR (uneducated). (confex.com)
Motif2
  • RAPT has discovered and advanced two unique drug candidates, RPT193 and FLX475, each targeting C-C motif chemokine receptor 4 (CCR4), for the treatment of inflammation and cancer, respectively. (rapt.com)
  • Chemokine (C-C motif) receptor 4 (CCR4) is expressed on the surface of effector Tregs involved in controlling alloimmune and autoimmune responses. (elsevierpure.com)
Antagonist1
Antigen3
  • Naïve T cells, bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes and express cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity to migrate into the skin to exert their normal effector functions (1). (biolegend.com)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
CXCR31
Cytokine1
  • We used single-cell analysis to investigate the relationship between chemokine receptor expression and cytokine production on peripheral blood and bronchoalveolar lavage fluid T cells in patients with asthma, a putative T(H)2 disease, as well as in healthy control subjects. (nih.gov)
Lymphocytes2
Seven transmembrane2
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
  • The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
CD1941
  • CCR4 has also recently been designated CD194 (cluster of differentiation 194). (wikipedia.org)
Cells19
  • CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). (wikipedia.org)
  • The concept of the polarization of chemokine receptor expression by T(H)1 and T(H)2 cells provides an attractive mechanism for their differential recruitment to tissue, which could be subject to disease-specific therapeutic intervention. (nih.gov)
  • We have found in both asthmatic and control subjects that IL-4-expressing blood and bronchoalveolar lavage fluid T cells are significantly more likely to express the T(H)2 type 2 chemokine receptors CCR 3 and CCR 4, with 10-fold and 2-fold differences in expression, respectively, compared with IFN-gamma-expressing cells. (nih.gov)
  • We confirmed the expression of CCR4 on both CD4+ T cells and ILC2, comparatively. (cdc.gov)
  • CCR4 is expressed in cutaneous regulatory T cells (Tregs). (biolegend.com)
  • The human NK cell repertoire is functionally diversified through a tightly regulated differentiation process characterized by an early transition from CD56bright to CD56dim NK cells, followed by coordinated changes in expression of inhibitory receptors, including NKG2A and killer cell immunoglobulin-like receptors (KIR). (confex.com)
  • We found that the chemokine-induced migration capability of NK cells correlated closely with the expression level of corresponding chemokine receptor, leading to subset specific responses to various chemokine gradients (D). (confex.com)
  • These cells expressed central nervous system-homing receptors, exhibited a dysregulated CD25-IL-2 axis, and their proliferative capacity positively correlated with MS severity. (nature.com)
  • Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules and chemokine receptors. (biomedcentral.com)
  • We reasoned that a bias (either enrichment or depletion) of CSF T cell expression of known organ-specific trafficking determinants might suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine receptor. (biomedcentral.com)
  • CSF contained similar proportions of CD4+ memory T cells expressing CLA, CCR4, integrin α4β7 and CCR9 as paired blood samples. (biomedcentral.com)
  • The differentiation of naïve T cells into an activated memory phenotype is characterized by an extensive change in the expression of trafficking determinants, resulting in the acquisition of homing receptors that enable the cells to migrate from the circulation into peripheral tissues. (biomedcentral.com)
  • The Phase 2a trial is initially focused on patients with Type 2-high asthma as RPT193 has been shown to selectively inhibit the migration of Th2 cells into inflamed tissues by blocking CCR4. (rapt.com)
  • All four adenosine receptors are expressed on the surface of mouse invariant NKT (iNKT) cells. (guidetomalariapharmacology.org)
  • One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
  • Recently we have developed a novel diphtheria-toxin based anti-human CCR4 immunotoxin for depleting CCR4 + cells in vivo. (elsevierpure.com)
  • The depletion lasted for about one week with no significant reduction observed within CCR4 − cell populations including CD8α + T cells, CCR4 − CD4 + T cells and B cells. (elsevierpure.com)
  • If there encodes a generation between active cardiomyocytes or cells also this investment can make maintain the most catalytic membrane for receptors with family. (erik-mill.de)
  • CCR4 is expressed on the surface of some T-cell malignancies and is expressed on regulatory T-cells (Treg) and a subset of Th2 T-cells. (mdtodate.com)
Subunit3
  • Orthologous to human CNOT6 (CCR4-NOT transcription complex subunit 6). (nih.gov)
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
Signaling molecules1
  • The receptor N-terminus is external and contributes to ligand binding while the carboxy terminus (COOH) allows for interaction with signaling molecules and downstream signaling. (biolegend.com)
Tumor1
  • Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. (cdc.gov)
Protein7
  • C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the G protein-coupled receptor family. (wikipedia.org)
  • CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression. (wikipedia.org)
  • Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85% identical to human CCR4. (biolegend.com)
  • The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
  • However, the complement C5a receptor 2 may act as a decoy receptor for C5a, as it has no reported G protein signalling capacity. (guidetomalariapharmacology.org)
  • May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. (cusabio.com)
Peripheral blood3
  • The present results show that peripheral blood NK cell chemokine receptor profile changes in a coordinated fashion during NK cell differentiation and is further influenced by the expression of self-specific KIR. (confex.com)
  • We observed depletion of up to 70-85% of the CCR4 + Foxp3 + porcine Tregs in the peripheral blood and 85-91% in the lymph nodes following the anti-human CCR4 immunotoxin treatment in Massachusetts General Hospital (MGH) miniature swine. (elsevierpure.com)
  • In summary, anti-human CCR4 immunotoxin effectively depleted CCR4 + Foxp3 + porcine Tregs in both peripheral blood and lymph nodes. (elsevierpure.com)
Tregs1
  • Anti-human CCR4 immunotoxin effectively depleted CCR4 + Foxp3 + porcine Tregs in vivo. (elsevierpure.com)
Cell8
  • FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017 Human CCR4 genome location and CCR4 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. (nih.gov)
  • In order to delineate the homing patterns of distinct NK cell subsets, we used high-dimensional flow cytometry combined with functional assays to map the NK cell chemokine receptor expression and migratory behavior. (confex.com)
  • We combined the high-throughput of mass cytometry, facilitating the analysis of 57 twin pairs, with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) of eight selected twin pairs to obtain a comprehensive overview of epitopes, transcriptome and T cell receptor (TCR) clonotypes. (nature.com)
  • The company's proprietary drug discovery and development engine has identified the cell surface receptor CCR4 as a drug target that potentially has broad applicability in oncology and inflammatory diseases. (cafepharma.com)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Processing at the N-terminus can regulate receptor and target cell selectivity. (affbiotech.cn)
  • MDC interacts with cell surface chemokine receptors CCR4. (neobiolab.com)
Tissues1
  • Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)
RPT1931
  • RAPT believes that by inhibiting CCR4, RPT193 has the potential to bring therapeutic benefit to patients across a broad spectrum of inflammatory diseases, including atopic dermatitis, asthma, chronic spontaneous urticaria, alopecia areata, prurigo nodularis, chronic rhinosinusitis with nasal polyps, allergic rhinitis and eosinophilic esophagitis. (rapt.com)
Human2
Signals1
Subunits1
  • Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
Genes1
  • Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
Type5
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
  • [7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
  • Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
  • [8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
CX3CR11
Phosphorylation1
  • Flow cytometry was applied to detect the expression of CCR4, IL-6, and the phosphorylation levels of NF-κB. (endometriosi.it)
Bind1
  • Rather all observations of receptors and factors are the reliable tyrosines but at best the kinase can initiate the loop and synthesis of the ricin, be the gene or significance on Text-to-Speech to bind physiological site. (erik-mill.de)
Eosinophils1
Potent1
  • Ohta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. (bindingdb.org)
Inflammation1