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  • neuronal
  • One of the aims of this field of research is to understand the action of amines in different neuronal and non-neuronal circuits using a variety of techniques including live imaging, microscopy, electrophysiology and molecular biology. (frontiersin.org)
  • The rapid turnover of trace amines, as evidenced by their dramatic increases following treatment with monoamine oxidase (MAO) inhibitors or deletion of the MAO genes, suggests that the levels of trace amines at neuronal synapses may be considerably higher than predicted by steady-state measures ( 2 - 5 ). (pnas.org)
  • In addition to activating adenosine A1 receptors and inhibiting the neuronal reuptake of norepinephrine and serotonin, amitriptyline produces antinociceptive effects, which appear to be mediated through the modulation of multiple subtypes of glutamate receptors including the N-methyl D-aspartate (NMDA) receptor. (cancer.gov)
  • TAAR1
  • These data provide the first evidence that common biogenic amines modulate monoamine transporter function via both TAAR1 and monoamine autoreceptors, which may balance monoaminergic activity. (aspetjournals.org)
  • In this study, we used transfected cells to evaluate the interaction of the common biogenic amines with TAAR1 and monoamine autoreceptors and clarify whether TAAR1 function is influenced by monoamine autoreceptors at exposure to the common biogenic amines. (aspetjournals.org)
  • hormones
  • Group 1 hormones (steroids, iodothyronines, calcitriol, retinoids) bind their receptor in the cytoplasm, form a dimer, move into the nucleus and bind DRE. (brainscape.com)
  • What are the second messengers for group 2 hormones following receptor activation. (brainscape.com)
  • monoamine
  • This study examines the effect of long-term elevation of brain monoamine levels on receptor/G-protein coupling by chronic administration of a highly potent tropane analog, WF-23 (2β-propanoyl-3β-(2-naphthyl) tropane). (emory.edu)
  • Receptor activation of G-proteins was determined by [35S]GTPγS autoradiography in brain sections for D2, 5-HT1A and α2-adrenergic receptors, as well as mu opioid receptors as a non-monoamine receptor control. (emory.edu)
  • αET and αMT , also tryptamines, are SNDRAs and non-selective serotonin receptor agonists that were originally thought to be monoamine oxidase inhibitors and were formerly used as antidepressants . (wikipedia.org)
  • insulin
  • Animals with mutations in insulin-related 1 ( ins-1 ), abnormal dauer formation 2 ( daf-2 ), and aging alteration 1 ( age-1 ), which encode the homolog of human insulin, insulin/IGF-1 receptor, and PIP3 kinase, respectively, demonstrated significant deficits in benzaldehyde-starvation associative plasticity. (jneurosci.org)
  • The components of insulin signaling, including the insulin homolog INS-1, its receptor DAF-2, and the PIP3-kinase homolog AGE-1, are highly conserved between C. elegans and mammals. (jneurosci.org)
  • compounds
  • The activity of the lead compounds can be improved by rational drug design (based on pharmacophore analysis or co-crystal structures with the receptor) and medicinal chemistry. (frontiersin.org)
  • Binding of Antidepressants to Human Brain Receptors: Focus on Newer Generation Compounds. (thefullwiki.org)
  • subfamily
  • Together with the orphan receptor PNR, these receptors form a subfamily of rhodopsin GPCRs distinct from, but related to the classical biogenic amine receptors. (pnas.org)
  • The 15 distinct receptors described here, along with the orphan receptor PNR ( 32 ) and the pseudogenes GPR58, GPR57 ( 33 ), and the 5-HT 4 pseudogene ( 34 ), share a high degree of sequence homology and together form a subfamily of rhodopsin GPCRs distinct from but related to 5-HT, DA, and NE receptors. (pnas.org)
  • effects
  • Species differences in aortic responses to vasoactive amines: the effects of compound 48-80, cocaine, reserpine and 6-hydroxydopamine. (semanticscholar.org)
  • Objective 1: Determine relationships of ergot alkaloids to receptors in animal tissues and subsequent effects on animal physiology, and the implications of these relationships on clearance from animal tissues. (usda.gov)
  • Endothelium cells from saphenous cells will also be exposed to ergot alkaloids to assess their effects on receptor signaling by ß-arrestin and G proteins. (usda.gov)
  • Halberstadt AL, Geyer MA (2011) Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. (springer.com)
  • interact
  • Experiments will be conducted to determine mechanisms by which ergot alkaloids interact with receptors in animal tissues and affect their physiology. (usda.gov)