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  • locus
  • This region represents the germline organization of the T cell receptor beta locus. (cancerindex.org)
  • The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. (cancerindex.org)
  • Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. (cancerindex.org)
  • Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (cancerindex.org)
  • The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci. (nih.gov)
  • J, joining) at the TCR-beta, TCR-gamma, and TCR-delta loci.Thus, the CD3 components are differentially involved in the sequential events that make the TCR-beta locus first accessible to, and later insulated from, the action of the V(D)J recombinase. (nih.gov)
  • Recent experiments in pre-Talpha chain-deficient mice have suggested that the pre-TCR may not be required for signaling allelic exclusion at the TCR-beta locus. (nih.gov)
  • Using CD3-epsilon- and CD3-zeta/eta-deficient mice harboring a productively rearranged TCR-beta transgene, we showed that the CD3-gammadeltaepsilon and CD3-zeta/eta modules, and by inference the pre-TCR/CD3 complex, are each essential for the establishment of allelic exclusion at the endogenous TCR-beta locus. (nih.gov)
  • interleukin
  • This activity of IFN-alpha/beta has not been described previously.It was due to direct effects of the IFNs on the T cells and was not mediated by induction of a second cytokine such as interleukin 15.Therefore, their activity was distinct from that of members of the interleukin 2 family or CD28 engagement. (nih.gov)
  • Two groups of cytokines were active, members of the interleukin 2 family and the interferons (IFNs) alpha and beta. (nih.gov)
  • It was due to direct effects of the IFNs on the T cells and was not mediated by induction of a second cytokine such as interleukin 15. (nih.gov)
  • Cytokine production and soluble interleukin 2 receptor (sIL-2R) secretion were determined by enzyme linked immunosorbent assays. (bmj.com)
  • PEPTIDE
  • These T cells recognize foreign MHC proteins and because MHC proteins can each bind a variety of endogenous peptides, the T cells recognize multiple ligands (i.e., different peptide/MHC complexes). (illinois.edu)
  • These findings are also discussed with regard to the potential for targeting autoimmune T cells and for peptide-based therapies that involve T-cell mediated tumor rejection. (illinois.edu)
  • CHAIN
  • Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. (cancerindex.org)
  • The pre-T cell receptor (TCR) associates with CD3-transducing subunits and triggers the selective expansion and maturation of T cell precursors expressing a TCR-beta chain. (nih.gov)
  • To determine whether the expression of a TCR-β chain transgene was able to inhibit endogenous Vβ to DβJβ rearrangements in the absence of CD3-ε subunit, CD3-εΔ5/Δ5 mice were crossed with transgenic mice carrying a productively rearranged Vβ8+ TCR-β chain derived from the P14 T cell clone (24, 28). (nih.gov)
  • In contrast to invariant NKT cells and MAIT cells, this population has a highly diverse TCRalpha-chain repertoire. (umassmed.edu)
  • Comparison of T-cell receptor beta chain expression profiles of CD8(+) T-cell lines and CD8(+) T cells harvested ex vivo confirmed that the composition of the T-cell lines was representative of the in vivo memory CD8(+) T-cell populations. (surrey.ac.uk)
  • Lantz O, Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. (pubmedcentralcanada.ca)
  • complex
  • Results showed that: (1) T cells that are specific for the p2Ca/L$\sp{\rm d}$ complex can be readily generated in vitro and (2) the T cells express a diverse TCR repertoire, although restrictions in the use of V$\beta$ and J$\beta$ regions were observed. (illinois.edu)
  • The predominant use of particular V$\beta$ and J$\beta$ regions are discussed in the context of a model for the interaction between the $\alpha\beta$ TCR and the p2Ca/L$\sp{\rm d}$ complex. (illinois.edu)
  • Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear. (surrey.ac.uk)
  • surface
  • Natural Killer (NK)1.1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that are normally associated with the NK cell lineage of the innate immune system. (pubmedcentralcanada.ca)
  • Lack of expression of any of the chains is sufficient to stop cell surface expression. (acris-antibodies.com)
  • This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional form on the bacterial cell surface. (jove.com)
  • strands in the C-terminal barrel domain, and mutations within these motifs slow the rate and extent of passenger domain translocation to the surface of bacterial cells. (jove.com)
  • lineage
  • We compared two postmitotic populations--one that appears committed to die and one that appears mature--and several blast cell populations that are enriched for precursors of one or another presumptive lineage. (caltech.edu)
  • Furthermore, our results show that the cells of the major cortical lineage, which have at least a 95% probability of death, nevertheless express high levels of mature mRNA encoding both the alpha- and the beta-chains of the T cell antigen receptor. (caltech.edu)
  • The position of the window (R1) used to identify the DN T lineage cells is shown in the top row for each type of mouse. (nih.gov)
  • In the bottom row, the DN T lineage cells were analyzed for the expression of CD25 and CD44. (nih.gov)
  • Starnes LM, Sorrentino A, Pelosi E et al (2009) NFI-a directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression. (springer.com)
  • Repertoire
  • If the long-term "hyperimmune" culture is indicative of the repertoire of cells that mediate transplant rejection, then such predominant TCR structures could serve as targets for specific suppression of transplant rejection. (illinois.edu)
  • DI-fusion Regulatory T cells constrain the TCR repertoire of. (ac.be)
  • Regulatory T cells constrain the TCR repertoire of antigen-stimulated conventional CD4 T cells. (ac.be)
  • soluble
  • Carr R, Huizinga TW (2000) Low soluble FcRIII receptor demonstrates reduced neutrophil reserves in preterm neonates. (springer.com)
  • determinant
  • In conclusion, we have demonstrated a profound immunodominance in the CD8(+) T-cell response to T. parva, which we propose is a major determinant of the parasite strain specificity of the response and hence immune protection. (surrey.ac.uk)
  • Lymph Nodes
  • Analysis of peripheral tissues indicates that itk(-/-) innate PLZF(+)CD4(+) T cells preferentially home to spleen and mesenteric lymph nodes owing to increased expression of gut-homing receptors, and that their expansion is regulated by commensal gut flora. (umassmed.edu)
  • ligand
  • However, the impact of MAIT TCR and MR1-ligand heterogeneity on MAIT cell biology is unclear. (edu.au)
  • induces
  • Stimulation by BMA031 induces no measurable IL-2 release, very low expression of the IL-2 receptor, and does not trigger cytotoxic effector function. (uni-regensburg.de)
  • heterodimer
  • Our laboratory continues to work on fundamental processes by which T lymphocytes recognize foreign pathogens including viruses such as smallpox, vaccinia, HIV, and influenza A. We have analyzed the basic function and structure of the T cell receptor (TCR) components: TCRalphabeta heterodimer, CD3epsilongamma and CD3epsilondelta heterodimers, and CD3zetazeta homodimer. (dana-farber.org)
  • Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. (pubmedcentralcanada.ca)
  • Melanoma
  • METHODS: Melanoma specific CTL lines were established by long term coculture with a human melanoma cell line (P-36). (bmj.com)
  • Chemokine
  • Shaik SS, Soltau TD, Chaturvedi G et al (2009) Low intensity shear stress increases endothelial elr+ cxc chemokine production via a focal adhesion kinase-p38(beta) mapk-nf-(kappa)b pathway. (springer.com)
  • innate
  • Innate PLZF+CD4+ alphabeta T cells develop and expand in the absence o" by Amanda L. Prince, Levi B. Watkin et al. (umassmed.edu)
  • We show that itk(-/-) innate PLZF(+)CD4(+) T cells are not CD1d-dependent NKT cells, MR1-dependent MAIT cells, or gammadelta T cells. (umassmed.edu)
  • These data support the conclusion that itk(-/-) innate PLZF(+)CD4(+) T cells are a novel subset of innate T cells. (umassmed.edu)
  • and Berg, Leslie J., "Innate PLZF+CD4+ alphabeta T cells develop and expand in the absence of Itk" (2014). (umassmed.edu)
  • As members of the T cell family, iNKT cells represent a subset that exhibits both innate and adaptive characteristics and directs ensuing immune responses. (springer.com)
  • Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM (2013) Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. (springer.com)
  • mitogenesis
  • however, both mitogenesis and death affect particular subpopulations of cells, suggesting the selective amplification and destruction of specific T cell clones. (caltech.edu)
  • vivo
  • T cells were activated in vivo, isolated, and cultured with the test reagents. (nih.gov)