• CONCLUSIONS: Association of shorter CAG repeats with PCOS is consistent with in vitro functional studies demonstrating higher activity of androgen receptors expressed from alleles with fewer CAG repeats, suggesting inherited alteration in androgen sensitivity may contribute to PCOS. (biomedsearch.com)
  • Although exposure of WT and αERKO Leydig cells to estrogen in vitro did not affect androgen biosynthesis, incubation with ICI 182,780 reduced T production by WT, but not αERKO, Leydig cells occasioned by incubation with ICI 182,780 suggests that of the ER subtypes, ERα has a regulatory role in Leydig cell steroidogenic function. (popcouncil.org)
  • Seviteronel (INO-464) is an oral, selective cytochrome P450c17a (CYP17) 17,20-lyase (lyase) and androgen receptor inhibitor with in vitro and in vivo anti-tumor activity. (springer.com)
  • In vitro studies have confirmed that AR activity varies with different CAG and GGN length and these variations may not only have influence on the effect of the natural ligand of the receptor but even modify the endocrine disrupting effect of environmental pollutants. (endocrine-abstracts.org)
  • A University of Rochester study helps to explain why men get liver cancer more often than women and opens the door for a new treatment pathway, by showing a direct link between the androgen receptor, which is more active in men, and the hepatitis B virus as it relates to the deadly cancer. (redorbit.com)
  • By uncovering this new and important pathway of androgen receptor destruction, we may one day be able to develop more effective treatments for a substantial proportion of prostate cancer patients who have developed resistance to standard antiandrogen therapy," said senior author Haojie Huang, PhD, a Mayo Clinic biochemist in Rochester, Minnesota. (empr.com)
  • A putative mechanism allowing prostate cancer (PCa) cells to grow under low levels of androgens, is the expression of constitutively active, C -terminally truncated AR lacking the AR-ligand binding domain (LBD). (mdpi.com)
  • The results suggest that abnormalities in male sex development induced by p,p'-DDE and related environmental chemicals may be mediated at the level of the androgen receptor. (nih.gov)
  • To investigate the molecular mechanisms of how BPA may affect ten different nuclear receptors, stable cell lines containing individual nuclear receptor ligand binding domain (LBD)-linked to the β-Gal reporter were examined by a quantitative high throughput screening (qHTS) format in the Tox21 Screening Program of the NIH. (pubmedcentralcanada.ca)
  • Since there are Food and Drug Administration-approved drugs that block the androgen receptor in men, the hope is that, if one could come up with a strategy that would demonstrate the effectiveness of these drugs in some women, that they could become clinically available for use in the clinic pretty quickly. (curetoday.com)
  • Androgens cause slow epiphysis, or maturation of the bones, but more of the potent epiphysis effect comes from the estrogen produced by aromatization of androgens. (wikipedia.org)
  • Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor ( AR ) binders and a clear insight into the structure-activity relationship of such coactivator mimics concerning helix length. (rsc.org)
  • Small added that although it can only be conjecture at this point, the increasing use of highly potent androgen receptor-targeted therapy may contribute to the increasing frequency of this entity. (cancernetwork.com)