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  • GluR1 AMPA
  • It is known from biochemical studies that GluR1 AMPA receptor subunits can be phosphorylated within their C terminal by cAMP-dependent protein kinase A (PKA), which is colocalized with the phosphatase calcineurin (i.e., phosphatase 2B). (jneurosci.org)
  • GluA2
  • Following cocaine exposure (either non-contingently or through self-administration), there is an increase in GluA2-lacking AMPA receptors. (nih.gov)
  • mitogen-activa
  • We show here that stimulation of presynaptic AMPA receptors induces activation of mitogen-activated protein kinase (MAPK) through a nonreceptor tyrosine kinase-dependent and Na + /Ca 2+ -independent mechanism. (jneurosci.org)
  • modulate
  • Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity. (abcam.com)
  • It is now well accepted that AMPA receptors are also present at the presynapse, where they are thought to modulate neurotransmitter release. (jneurosci.org)
  • inhibitor
  • Similarly, Cα-PKA increased P O,PEAK for recombinant GluR1 receptors (0.78) compared with patches excised from cells cotransfected with a cDNA encoding the PKA peptide inhibitor PKI ( P O,PEAK 0.50) or patches with calcineurin included in the pipette ( P O,PEAK 0.42). (jneurosci.org)
  • stimulation
  • After stimulation of presynaptic AMPA receptors, synapsin I is phosphorylated at MAPK-specific sites. (jneurosci.org)
  • In addition to their important physiological role, excessive AMPA receptor stimulation is also a hallmark of excitotoxicity-related diseases, like ischaemic stroke. (eurekaselect.com)
  • Finally, stimulation after removal of philanthotoxin resulted in reversal of AMPA-eEPSC block, verifying strict use dependence of philanthotoxin. (jneurosci.org)
  • neuronal activity
  • Administration of the AMPAkine drug CX546 [1-(1,4-benzodioxan-6-ylcarbonyl)piperidine] to potentiate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity during emergence from anesthesia in mice enhances neuronal activity and prevents long-term motor learning deficits induced by repeated neonatal anesthesia. (sciencemag.org)