Receptors also binding to cd80 and cd86. Medical search. Frequent questions

b) In a novel approach for construction of a synthetic immune niche, many of the cell-bound and ECM-associated ligands are transferred to a synthetic 2D (left) or 3D scaffold (right), to which T cells can bind. (weizmann.ac.il)
However, in the treatment of diseases such as chronic pruritus, asthma, and allergic rhinitis, the use of selective H4R ligands and/or modulation of H1 and H4 receptor synergism may be more effective for such pathophysiological conditions. (hindawi.com)
The KS model postulates that, when small receptors engage their ligands within areas of close (∼15 nm) contact in the T cell/APC interface, this facilitates phosphorylation by segregating the engaged receptor/ligand complex from receptor protein tyrosine phosphatases with large ectodomains, such as CD45. (aai.org)
Programmed cell death 1 (PD‐1) and its ligands PD‐L1 and PD‐L2 are receptors that act in co‐stimulatory and coinhibitory immune responses. (fdxbhc.com)
CTLA-4 depletes CD80 and CD86 ligands of neighboring APCs through trans-endocytosis to impair the CD28-CD80/CD86 stimulation so as to down regulate the T-cell immune response (Qureshi et al. (scienceexhibitions.org)
The B7 family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. (bio-connect.nl)
Activation of T and B lymphocytes is initiated by engagement of cell-surface, antigen-specific T cell or B cell receptors, but additional signals delivered simultaneously by B7 ligands determine the ultimate immune response. (bio-connect.nl)
These "costimulatory" or "coinhibitory" signals are delivered by B7 ligands through the CD28 family of receptors on lymphocytes, resulting also in the modulation of interleukin production. (bio-connect.nl)
Many TLR ligands bind to specific receptors to market MyD88 homodimerization and MyD88 recruits IRAK4, IRAK1, IRAK2, TRAF6 to stimulate inflammatory replies by activating MAPKs8 and NF-B,16. (sipurpashut.net)
Using blocking antibodies, we demonstrate that the inhibition of T cell proliferation occurs through cell-to-cell interactions implicating PD-1 receptor expressed on T cells and its ligands, PD-L1 and PD-L2, on fibroblasts. (crcm-marseille.fr)
However, TIGIT exerts its functions not only by direct cell-intrinsic inhibitory signaling, but like CTLA4 which blocks binding of its co-stimulatory counterpart CD28 to their shared ligands CD80 and CD86, also in an indirect way. (greatlakeshighereducationnow.com)

It provides a dominant negative signaling to T cells on binding to the costimulatory molecules CD80 (B7.1) and CD86 (B7.2) expressed on the surface of antigen-presenting cells ( 1 ). (snmjournals.org)
Cell surface CTLA4 has 100-1,000 times higher affinity for the costimulatory molecules expressed by antigen-presenting cells, thereby efficiently competing with the positive costimulatory receptor CD28 ( 1 ). (snmjournals.org)
CTLA-4 is related to the T cell co-stimulatory receptor CD28, and acts to suppress T cell function by competing with CD28 for binding to CD80 and CD86 on antigen presenting cells and recruiting inhibitory molecules into the TCR signaling synapse. (sanguinebio.com)
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. (abeomics.com)
Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells (APC). (biolegend.com)
CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. (hostforstudent.com)

The engagement of CTLA4 by costimulatory molecules results in decreased T-cell receptor signaling, interleukin 2 transcription ( 3 ), and cell cycle arrest at the G1 stage, with the final result of inducing T-cell anergy ( 4 , 5 ). (snmjournals.org)
a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)
In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
Confocal microscopy revealed that elongated CD80 molecules were less well segregated from CD45 at the T cell/APC interface. (aai.org)
Both express co‐stimulatory molecules such as CD80 and CD86, which belong to the B7 family. (fdxbhc.com)
We marked of B7-1(CD80) and B7-2(CD86) costimulatory molecules. (annexpublishers.co)
This is the first communication of CD80 and CD86 costimulatory molecules in NETs. (annexpublishers.co)
B7 molecules (B7-1/CD80 and B7-2/CD86) are integral membrane glycoproteins that are expressed on the surface of APCs. (annexpublishers.co)
There are four classes of IgG molecules in both humans and mice, and each bind to different Fcg receptors with varying affinity. (sanguinebio.com)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)

T cell activation leads to increased expression of CTLA-4 an inhibitory receptor which binds to CD80 and CD86 on APCs. (scienceexhibitions.org)
Some APCs also bind native (or unprocessed) antigens to their surface, such as follicular dendritic cells , but unprocessed antigens do not interact with T cells and are not involved in their activation. (wikidoc.org)
4) TIGIT binds to CD155 on APCs to induce IL-10 production and decrease IL-12 production which indirectly inhibits T cells. (greatlakeshighereducationnow.com)

Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)
sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. (biolegend.com)

This presentation step is necessary because TCRs cannot bind antigens directly. (nanoteintech.com)
The antigens that bind to MHC proteins are always short peptides , 8-10 amino acids long for MHC Class I, and up to 25 or so for MHC Class II. (wikidoc.org)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)

This peptide-MHC complex signals through the T cell receptor and its associated proteins. (nih.gov)
Signal 2 is provided by costimulatory proteins, especially the B7 proteins (CD80 and CD86), which are recognized by the co-receptor protein CD28 on the surface of the T cell. (nih.gov)
It is associated with a complex of invariant transmembrane proteins called CD3 , which transduces the binding of the peptide- MHC complex into intracellular signals ( Figure 24-63 ). (nih.gov)
For most activation events, the antigen-presenting cell (APC) uses a functional group of membrane proteins called a major histocompatibility complex (MHC) to present the antigen to T cell receptors (TCRs) on the surface of the T cell. (nanoteintech.com)
For example, helper T cells have a co-stimulatory receptor called CD28 that binds proteins CD80 and CD86. (nanoteintech.com)
[ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)

In summary, the effectiveness of CD28 costimulation is inversely proportional to the dimensions of the CD28-CD80 complex. (aai.org)
Small CD28-CD80 complex dimensions are required for optimal costimulation by segregation from large inhibitory tyrosine phosphatases. (aai.org)

The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid exchange of binding partners with properties of liquid-liquid phase transitions, thereby acting as an intermediary between freely diffusing glycoproteins and stable complexes in the membrane. (gr.jp)
Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. (hindawi.com)
The double and simultaneous molecular interaction between antigen-presentig cells (APC) and T lymphocytes is essential for the optimal activation of the immunological response and requires the participation of two membrane receptor groups. (reumatologiaclinica.org)
In this way, the drug inhibits T cell activation, selectively blocking the specific interaction of CD80/CD86 receptors to CD28 and, therefore, inhibiting T cell proliferation and B cell immunological response. (reumatologiaclinica.org)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
Interaction of B7-family members with costimulatory receptors augments immune responses and interaction with coinhibitory receptors attenuates immune responses. (bio-connect.nl)

Transcriptome analysis of mouse spleen cells cultured with miso and its raw material revealed that the expression of genes, including interleukin (IL)-10, IL-22 and CD86, was upregulated. (bvsalud.org)

Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)

The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a coinhibitory activation-induced surface receptor on T cells that functions as a major negative regulator of anti-self-immune responses. (snmjournals.org)
Overall, exploiting the impact of histamine on innate and adaptive immune responses may be helpful for understanding receptor signaling and trends during inflammation or regulation. (hindawi.com)
The CTLA-4/Compact disc28-CD80/CD86 pathway is a critical co-stimulatory pathway for adaptive immune responses. (scienceexhibitions.org)
The objective of this study was to explore the role of the aryl hydrocarbon receptor (AhR) in ambient particulate matter (PM)-mediated activation of dendritic cells (DCs) and Th17-immune responses in vitro. (cdc.gov)

Abatacept is a fusion protein that selectively modulates one of these two ways, by binding to CD80 and CD86 receptors on APC. (reumatologiaclinica.org)
Using (i) different purified enzymatic activities, (ii) MMP-specific inhibitors, and (iii) recombinant human MMP-9 and MMP-13, we demonstrated that in contrast to CD80/CD86, PD-L1 was selectively cleaved by MMP-13, while PD-L2 was sensitive to broader MMP activities. (crcm-marseille.fr)
Unlike folate-drug conjugates, m909 selectively binds to FRβ, does not recognize FRα, and has at least one effector function. (biomedcentral.com)

Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)
Most naïve T cells do not express surface CTLA4 because of its binding to AP50, a subunit of the clathrin adaptor AP-2 protein ( 2 ). (snmjournals.org)
Histamine and its receptors represent a complex system of immunoregulation with distinct effects mediated by four GPCRs (G protein-coupled receptors HRs 1-4) and their differential expression, which changes according to the stage of cell differentiation and microenvironmental influences. (hindawi.com)
The pleiotropic effects of histamine are mediated by 4 histamine receptors (HRs), H1R, H2R, H3R, and H4R, which are G protein-coupled receptors. (hindawi.com)
Signal 1 is provided by a foreign peptide bound to an MHC protein on the surface of the presenting cell. (nih.gov)
A second article in the same issue of The Journal of Experimental Medicine by Bulliard et al also explored the role of FcgR engagement on the effects of Ipilimumab as well as an agonistic antibody (DTA-1) targeting the T cell activating receptor GITR (TNFR glucocorticoid-induced TNFR-related protein), which is also expressed on both activated T cells and T REG s. (sanguinebio.com)
Dual PD-1 ligand neutralization is required to abrogate (i) binding of the PD-1-Fc fusion protein, (ii) early apoptosis of T cells, and (iii) inhibition of T cell proliferation. (crcm-marseille.fr)
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells. (hostforstudent.com)
When CTLA-4 is bound to another protein called B7, it helps keep T cells from killing other cells, including cancer cells. (hostforstudent.com)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)

In addition to TCR binding to cognate peptide-MHC (pMHC), the engagement of a second "costimulatory" receptor is usually required for the full activation and differentiation of naive T cells. (aai.org)
Specificity : The mouse monoclonal antibody JJ319 reacts with an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells. (abeomics.com)

CD86 exhibits constitutive expression on resting monocytes, macrophages and dendritic cells. (annexpublishers.co)

CD4+ T cells require three complementary signals to become fully activated-the T‐cell receptor (TCR) signal, co‐stimulation/inhibition signals, and cytokine priming. (fdxbhc.com)
In the same cells without stimulation CD80 expression is absent or low [ 14 ]. (annexpublishers.co)
TIGIT can compete for ligand binding with CD226 thereby reducing T-cell co-stimulation CD226 (51). (greatlakeshighereducationnow.com)

Binding specificity and affinity to the target cells was analyzed using flow cytometry. (scienceexhibitions.org)

The CD8 + coreceptor is expressed by cytotoxic T cells that help bind the class I MHC and can migrate through the walls of blood vessels and non-lymphoid tissues once activated. (nanoteintech.com)
Both helper and cytotoxic T cells require several secondary signals or coreceptor binding events to become fully activated and execute a certain function. (nanoteintech.com)
Presently, dual-immune checkpoint inhibition with anti-programmed death receptor-1/programmed cell death receptor- ligand-1 (anti-PD-1/PD-L1) plus anti-cytotoxic T lymphocyte associated antigen-4 (anti-CTLA-4) monoclonal antibodies (MoAbs) is being evaluated for a wide range of tumor histologies. (biomedcentral.com)

Fc g receptors are a multi-family class of immunoglobulin ( IgG )-binding receptors that initiate either activating or inhibitory signals when engaged. (sanguinebio.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

The numbers of circulating CD4+CXCR5+, CD4+CXCR5+ICOS+, CD4+CXCR5+PD-1+, CD4+CXCR5+IL-21+ TFH, CD19+CD86+, and CD19 +CD86+CD38+ B cells as well as the level of serum IL-21 in the AMR, AR, and CR groups at post-transplantation were significantly higher than those at pre-transplantation. (bvsalud.org)
Moreover, the numbers of circulating CD4+CXCR5+IL-21+ TFH cells, CD19+CD86+CD38+ B cells as well as the level of serum IL-21 were positive related to the level of serum Cr while showing negative correlated with the values of eGFR in the AMR groups at post-transplantation for 4 and 12 weeks. (bvsalud.org)

Once a T cell is activated through its T-cell receptor, downstream T-cell receptor signaling through Src kinases results in tyrosine phosphorylation of CTLA4 and the uncoupling of CTLA4 from AP50, allowing its surface expression, which peaks at 48 h after activation. (snmjournals.org)
Inflammatory conditions (e.g., allergy, asthma, and autoimmune diseases) have long been thought to be mainly mediated by the activation of histamine receptor 1 (H1R). (hindawi.com)
A general overview of the immune cascades triggered by histamine receptor activation is provided. (hindawi.com)
Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. (aai.org)
One known exception to the T-cell MHC binding-activation rule is natural killer T cells (NKT), which act as a bridge between the innate and adaptive immune systems. (nanoteintech.com)
PM2.5 significantly induced AhR DNA binding activity to dioxin responsive elements (DRE) and expression of the AhR repressor (AhRR), cytochrome P450 (CYP) 1A1, and CYP1B1, indicating activation of the AhR. (cdc.gov)
Activating receptors contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAM) and activate the FcgR-expressing cell to mediate functions including antibody-dependant cell mediated cytotoxicity (ADCC) and phagocytosis of the antibody-labeled target cell. (sanguinebio.com)
Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation. (rndsystems.com)
The Mechanisms of TIGIT Co-Inhibition While all Rabbit polyclonal to VDAC1 co-inhibitory receptors have the ability to suppress T cell activation, they differ in potency, kinetics of expression and with respect to the cellular signaling pathways they alter. (greatlakeshighereducationnow.com)

The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)
Their cleavage by exogenous MMP-9 and MMP-13 with loss of PD-1 binding domain resulted in the reversion of apoptotic signals on mitogen-activated CD3 T cells. (crcm-marseille.fr)
1) TIGIT binds to CD155 and delivers intracellular inhibitory signals which directly reduces TCR-expression and TCR signaling. (greatlakeshighereducationnow.com)

Fab m909 bound with relatively high affinity (equilibrium dissociation constant 57 nM) to FRβ. (biomedcentral.com)

In LPS assay at 120 min CD80 and CD86 colocalized with neutrophil elastase (NE) in NETs. (annexpublishers.co)

The addition of an anti-MHC-II antibody to the CD86+MHC-II+ DC group significantly increased induction. (bvsalud.org)

a4) Activated T-cells form intercellular contacts with each other and cluster through ICAM-1-LFA-1 binding. (weizmann.ac.il)
To test this hypothesis, we examined the effect of elongating the extracellular region of the CD28 ligand, CD80, on its ability to costimulate IL-2 production by primary T cells. (aai.org)
T cells expressing CD28 harboring a key tyrosine-170 mutation were less sensitive to CD80 elongation. (aai.org)
Here they undergo thymus-dependent T cell differentiation to express T cell receptors (TCR) on their surface, eventually creating mature, but naive, immune T cells. (nanoteintech.com)
The CD4 + coreceptor is expressed by helper T cells and helps bind to class II MHC. (nanoteintech.com)
We found that immature bone marrow dendritic cells (CD86+MHC-II- DCs), rather than mature DCs (CD86+MHC-II+), induced high levels of iDNT cells. (bvsalud.org)
Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization. (cdc.gov)
Ipilimumab functions to increase the ratio of effector T cells to T REGS in the tumor microenvironment and has been shown to require binding to both types of T cells for maximal anti-tumor effectiveness. (sanguinebio.com)
Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
Helper T cells recognize these, with the help of their expression of CD4 co-receptor ( CD4+ ). (wikidoc.org)
Like all T cells, they express the T cell receptor / CD3 complex. (wikidoc.org)
Once at the lymph nodes, the APC begins to present antigen peptides that are bound to Class II MHC, allowing CD4 + T cells that express specific TcR's against the peptide/MHC complex to activate. (wikidoc.org)
In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
Folate receptor beta (FRβ) is only detectable in placenta and limited to some hematopoietic cells of myeloid lineage in healthy people. (biomedcentral.com)
The IgG1 m909 showed much higher (femtomolar) avidity as measured by ELISA, and it bound to FRβ positive cells in a dose-dependent manner, but not to parental FRβ negative cells. (biomedcentral.com)
m909 did not compete with folate for the binding to FRβ on cells. (biomedcentral.com)
In addition to RFC and PCFT, a limited number of cells express folate receptors (FRs) that can mediate unidirectional transportation of folates into cells. (biomedcentral.com)
Binding of TIGIT on NK cells to its ligand CD155 suppresses NK-cell mediated cytotoxicity and IFN- production through signaling cascades generated by ITIM and ITT-like motifs in its cytoplasmic tail (22C24). (greatlakeshighereducationnow.com)
It binds to an ICOS ligand expressed by B-cells, macrophages, and DCs. (hostforstudent.com)

The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains, and (ii) promotes turnover of cell-cell contacts such as immune synapses and focal adhesion complexes. (gr.jp)

The T cell receptor does not act on its own to transmit signal 1 into the cell. (nih.gov)
The T cell receptor and its associated CD3 complex. (nih.gov)
The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1). (nih.gov)
If the T cell's TCR binds to an antigen-presenting MHC on another cell, the T cell may activate. (nanoteintech.com)
Certain T cell types only recognize and bind to a particular MHC class. (nanoteintech.com)
Conclusions: CRC with MMR-D showed a higher CD80 expression, and CD8+ and Th1 T-cell infiltration. (oncotarget.com)
The presence of CD80 and CD86 in NETs could influence the cell environment through the B7-1/B7-2:CD28/CTLA-4 pathway. (annexpublishers.co)
The T cell receptor (TcR) consists of both constant and variable regions, the latter of which determines what antigen the T cell can respond to. (wikidoc.org)

The expression of MMR genes (MSH2, MLH1, MSH6 and PSM2) and co-stimulatory molecule CD80 was assessed by tissue microarray immunohistochemistry. (oncotarget.com)
The effect of specific siRNA (siMSH2, siMLH1, siMSH6 and siPSM2) transfection in HT29 on CD80 expression was quantified by flow cytometry. (oncotarget.com)
Results: Patients with MMR-D showed a higher T-bet/CD4 ratio ( p = 0.02), a higher rate of CD80 expression and CD8 lymphocyte infiltration compared to those with no MMR-D. Moreover, in the MMR-D group, the Treg marker FoxP-3 was not expressed ( p = 0.05). (oncotarget.com)

Furthermore, many adapters and receptors in the TLR/MyD88 signaling pathway of innate immunity include a TIR domains, which contains many conserved residues highly. (sipurpashut.net)

Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

FcgRIIB is the single inhibitory Fc g receptor in mice and humans and contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) which instead downregulates cellular responses. (sanguinebio.com)

Thus differential affinities of IgG subclasses to functionally different Fcg receptors are thought to mediate the variation in clinical effectiveness of different antibodies targeting the same antigen. (sanguinebio.com)

The active and inactive conformations of these receptors coexist in equilibrium. (hindawi.com)

Binding of Fab and IgG1 m909 to FRβ was measured by ELISA, surface plasmon resonance, immune fluorescence staining, and flow cytometry. (biomedcentral.com)

Because m909 does not compete with folate for receptor binding, it can be used with folate-drug conjugates in a combination therapy. (biomedcentral.com)

Anatomy39

Organisms12

Diseases6

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes37

Disciplines and Occupations1

Information Science3

Health Care1

Ligands11

Antigen-prese6

Molecules10

APCs3

B7.12

Antigens3

Proteins6

CD28-CD802

Interaction7

Interleukin1

Dendritic cell1

Immune responses4

Selectively3

Protein10

Costimulatory receptor2

Constitutive expression1

Stimulation3

Analyzed using flow cyt1

Cytotoxic3

Immunoglobulin2

CD192

Activation9

Signals3

Affinity1

Assay1

Antibody1

Cells19

Regulates1

Cell8

Expression3

Pathway1

Membrane1

Immunoreceptor1

Mediate1

Equilibrium1

Flow1

Compete1