• Fang ( 2003 ) published the EDKB androgen receptor (AR) binding dataset that was produced expressly as a training set designed for developing predictive models. (fda.gov)
  • Selective androgen receptor modulators (SARMs) are essentially prostate sparing androgens, which provide therapeutic potential in osteoporosis, male hormone replacement, and muscle wasting. (rcsb.org)
  • Herein we report crystal structures of the androgen receptor (AR) ligand-binding domain (LBD) complexed to a series of potent synthetic nonsteroidal SARMs with a substituted pendant arene referred to as the B-ring. (rcsb.org)
  • The mechanism by which the androgen receptor (AR) distinguishes between agonist and antagonist ligands is poorly understood. (rcsb.org)
  • Recently, our laboratory discovered selective androgen receptor modulators, which structurally resemble the nonsteroidal AR antagonists bicalutamide and hydroxyflutamide but act as agonists for the androgen receptor in a tissue-selective manner. (rcsb.org)
  • The crucial role of androgen receptor (AR) in prostate cancer development is well documented, and its inhibition is a mainstay of prostate cancer treatment. (caltech.edu)
  • Here, we analyze the perturbations to the AR cistrome caused by a minor groove binding molecule that is designed to target a sequence found in a subset of androgen response elements (ARE). (caltech.edu)
  • Etonogestrel has approximately the same ability to bind to the androgen receptor in fish as levonorgestrel. (janusinfo.se)
  • A substance's ability to activate the androgen receptor in fish is believed to contribute to increased risk of environmental impact. (janusinfo.se)
  • The extracellular domain consists of the ligand binding domain (LBD), responsible for primary agonist binding, followed by the cysteine rich domain (CRD), which mainly serves as a linker between the LBD and the transmembrane region ( Fig. 1a ). (nature.com)
  • They carry a special receptor called the T-cell receptor on their surface that recognizes antigens - small protein fragments of bacteria, viruses and infected or cancerous body cells - which are presented by specialized immune complexes. (news-medical.net)
  • However, how this signaling pathway is activated has remained a mystery until now - despite the fact that the T-cell receptor is one of the most extensively studied receptor protein complexes. (news-medical.net)
  • T1rs are class C G-protein coupled receptors (GPCRs), and the extracellular ligand binding domains (LBDs) of T1r1/T1r3 and T1r2/T1r3 heterodimers are responsible for binding of chemical substances eliciting umami or sweet taste. (nature.com)
  • The receptor activation mechanism of the class A GPCR members, consisting solely of the transmembrane region, has been considered to occur via agonist binding, which changes the conformational dynamics of the protein by lowering the transition energy between the different states, and results in the transition towards the active-state conformation 9 . (nature.com)
  • Thus, while cardiac muscarinic receptors are coded for by a single mRNA and are therefore genetically homogeneous, the resulting receptor protein might behave like a mixture of receptor subtypes in intact tissues due to the influence of intracellular factors on receptor conformation. (nih.gov)
  • Maximum binding values for [3H]PZ and [3H]QNB binding to solubilized receptors were approximately 400 and 950 fmol/mg of protein, respectively. (unboundmedicine.com)
  • Wucherpfennig, K.W. and Hafler, D.A. (1995) A review of T-cell receptors in multiple sclerosis: Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. (scirp.org)
  • The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. (sinica.edu.tw)
  • The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
  • X-ray crystallography of the receptor-binding protein, haemagglutinin (HA), in complex with receptor analogues indicates that both human and avian receptors adopt different conformations when bound to human H7 HA than they do when bound to avian H7 HA. (flutrackers.com)
  • The stated purpose of the study was to see if chlorine dioxide directly inhibits the binding of the Chinese Virus Spike protein (S protein) to ACE2 receptors. (naturalnews.com)
  • In the end, what they found is that MMS does, in fact, inactivate the binding of covid variant spike proteins to the human ACE2 receptor protein, "indicating that this strategy may be useful in blocking the transmission of variant SARS-CoV-2 viruses. (naturalnews.com)
  • Upon analysis, it was determined that the intensity of the binding of human ACE2 protein to covid spike RBD decreased as a result of chlorine dioxide. (naturalnews.com)
  • The higher the concentration of chlorine dioxide, the fewer spike protein binding events were observed. (naturalnews.com)
  • The outlined protocol describes the procedure for producing the HiBiT-receptor-binding domain protein complex and its application for fast and sensitive detection of SARS-CoV-2 antibodies. (jove.com)
  • Using a novel approach of co-immunoprecipitation with antibodies to E2 for capture, we identified binding of E2:ERα complexes to FOXP3 protein in CxCa-derived Treg cells. (ncbs.res.in)
  • Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor binding domain (RBD) of SARS-CoV-2 to human angiotensin converting enzyme 2 (hACE2), and effectively neutralize S protein-pseudotyped virus infection. (medrxiv.org)
  • In this work, in silico selection of DNA-aptamers to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was performed using molecular modeling methods. (jyu.fi)
  • Binding of the each modeled aptamer to the RBD was studied in terms of interactions between residues in protein and nucleotides in the aptamers. (jyu.fi)
  • Carbohydrate - protein inte ractions in nature are often mediated via multivalent binding where the combined strength of multiple receptor - ligand interactions results in a binding that is highly specific and strong. (avhandlingar.se)
  • Here we show that in cells depleted of the SRP protein, Ffh or the translocon component SecE, the ribosomal targeting pathway is blocked downstream and unprecedented, membrane-bound FtsY-ribosomal complexes are captured. (rupress.org)
  • 2000. Assessing the role of ortho -substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. (cdc.gov)
  • Figure 1: Taste Receptor T1r Proteins from Medaka Fish (mf). (nature.com)
  • Binding of hemagglutinin proteins is indicated in relative fluorescence units (RFU). (cdc.gov)
  • Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity. (cdc.gov)
  • A paper published in the journal Annals of Pharmacology and Pharmaceutics explains how MMS blocks the spike proteins associated with SARS-CoV-2 that are said to bind with human receptors such as Angiotensin-Converting Enzyme 2 (ACE2), allowing disease to form. (naturalnews.com)
  • It may also be useful in helping the vaccinated and those who test "positive" for the China Virus to rid themselves of spike proteins by preventing them from attaching to ACE2 receptors. (naturalnews.com)
  • For their experiments, the team sprayed a 50 ?L aliquot of chlorine dioxide or chlorine dioxide spray solution diluted to the appropriate concentration onto microtiter plates containing purified Receptor-Binding Domain (RBD) spike proteins. (naturalnews.com)
  • The information molecules released by the transmitter nano-machine into the environment can degrade in the channel via a first-order degradation reaction and those that reach the receiver nano-machine can participate in a reversible bimolecular reaction with receiver receptor proteins. (embs.org)
  • In this thesis we have produced proteins that are densely decorated with carbohydrate determinants in order to study the glycosylation capacity of cell lines (paper I) and generate efficient binders of antibodies (paper II), bacterial toxins (paper III) and virus receptors such as the influenza hemagglutinin (paper IV). (avhandlingar.se)
  • Recently, it has been recognized that membrane-bound ribosomes are crucial for biogenesis of integral membrane proteins in E. coli , thus renewing interest in ribosome targeting to and association with the membrane in this organism. (rupress.org)
  • We review the structural data available for receptor and ligands and identify the challenges ahead. (nih.gov)
  • Using docking of suspected ligands, we were able to show Guanine and Adenine diand tri-nucleotides readily bind to the identified site. (scirp.org)
  • To investigate why subtle structural changes to both the ligand and the receptor (i.e. mutations) result in drastic changes in activity, we studied structure-activity relationships for nonsteroidal AR ligands through crystallography and site-directed mutagenesis, comparing bound conformations of R-bicalutamide, hydroxyflutamide, and two previously reported nonsteroidal androgens, S-1 and R-3. (rcsb.org)
  • These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. (reactome.org)
  • Classical alpha antagonists inhibit binding of both ligands at low concentrations, but beta antagonists are much weaker. (aspetjournals.org)
  • Partial agonist ergot alkaloids display similar affinities for the binding sites of both [ 3 H]ligands. (aspetjournals.org)
  • Regional variations in the binding of both [ 3 H]ligands in the brain are not pronounced, although levels tend to be highest in hypothalamus and cerebral cortex and lowest in cerebellum. (aspetjournals.org)
  • But what makes the sigma receptors so great is the fact that they bind a variety of ligands. (umsystem.edu)
  • The phenylpiperazine and phenylpiperidine chemical classes of ligands have been identified to bind at sigma1 receptor sites and a pharmacological model has been proposed. (umsystem.edu)
  • p75NTR is an unusual member of this family due to its propensity to dimerize rather than trimerize, because of its ability to act as a tyrosine kinase co-receptor, and because the neurotrophins are structurally unrelated to the ligands, which typically bind TNFR family members. (wikipedia.org)
  • Indeed, with the exception of p75NTR, essentially all members of the TNFR family preferentially bind structurally related trimeric Type II transmembrane ligands, members of the TNF ligand superfamily. (wikipedia.org)
  • Most of the d-LSD- binding sites may be associated with a post-synaptic serotonin receptor, instead of presynaptic recepors with serotonergic inputs. (erowid.org)
  • Our evidence suggests that D-[3H]LSD binds to post-synaptic serotonin receptors. (erowid.org)
  • The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. (nature.com)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
  • Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)
  • Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
  • Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
  • Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
  • Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
  • In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
  • Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. (nature.com)
  • Results: Our results demonstrated either free 17β-estradiol (E2) or membrane-impermeable bovine serum albumin-conjugated E2 (E2-BSA) could modulate human apoM gene expression via the estrogen receptor alpha (ER-α) pathway in the HepG2 cells. (lu.se)
  • 2004). Phytoestrogens are capable of estrogen-receptor binding (Cornwell et al. (cdc.gov)
  • Synergistic activation of estrogen receptor with combinations of environmental chemicals. (cdc.gov)
  • The selective antagonists pirenzepine and AF-DX 116 bind to this receptor with a single affinity: low and high, respectively. (nih.gov)
  • We report here that an endogenous, intracellular factor alters the affinity of selective antagonists for muscarinic receptors in the heart. (nih.gov)
  • Approximately 30% of the receptors bind pirenzepine with high affinity and AF-DX 116 with low affinity. (nih.gov)
  • This information elucidates interactions important for high AR binding affinity and provides new insight for structure-based drug design. (rcsb.org)
  • A rapid filration technique was used to determine high - affinity d-LSD binding in brain fractions. (erowid.org)
  • D-[3H]LSD binds saturably, reversibly, and with a high affinity (KD = 10 nM) to rat brain membranes. (erowid.org)
  • Serotonin is the only putative neurotransmitter with affinity (EDso = 3 mcM) for the LSD binding site, and psychotropically active alkylindoleamines are also potent displacing agents. (erowid.org)
  • Destruction of presynaptic serotonin neuronal elements by lesioning the midbrain raphe nuclei does not change the affinity or maximum number of detectable in vitro D-[3H]LSD binding sites. (erowid.org)
  • The regional distribution in monkey brain of D-[3H]LSD binding and high affinity [3H]serotonin uptake, a marker for pre-synaptic serotonin nerve terminal density, shows some correlation. (erowid.org)
  • We find that the human H7 virus has significantly higher affinity for α-2,6-linked sialic acid analogues ('human receptor') than avian H7 while retaining the strong binding to α-2,3-linked sialic acid analogues ('avian receptor') characteristic of avian viruses. (flutrackers.com)
  • Muscarinic cholinergic receptor binding sites differentiated by their affinity for pirenzepine do not interconvert. (aspetjournals.org)
  • If interconversion of high (M1) and low (M2) affinity binding sites for PZ occurs, incubation of cerebral cortical membranes with PBCM in the presence of PZ should not alter the proportions of M1 and M2 binding sites that are unalkylated (i.e., protected). (aspetjournals.org)
  • This research project is focused on the preparation of a Tc-99m labeled complex designed to retain high affinity to the sigma1 receptor subtype. (umsystem.edu)
  • Biacore biosensor assays indicated that PSGL - 1/mIgG 2b carrying the blood group P1 determinant in multiple copies bound with high affinity to Stx1 and Stx2, while PSGL - 1/mIgG 2b presenting multiple copies of Sia α 2,3Gal on different O - linked cores bound with high affinity to avian influenza H5. (avhandlingar.se)
  • The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. (wikipedia.org)
  • Two distinct subpopulations of Olfactory ensheathing glia have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). (wikipedia.org)
  • Although it has been suggested by many investigators that subtypes of muscarinic cholinergic receptors exist, physical studies of solubilized receptors have indicated that only a single molecular species may exist. (aspetjournals.org)
  • The muscarinic receptor antagonists atropine, scopolamine and PZ inhibited the binding of [3H]QNB and [3H]PZ to solubilized receptors with Hill slopes of 1, as did the muscarinic receptor agonist oxotremorine. (unboundmedicine.com)
  • Together, these data suggest that muscarinic receptor sites solubilized from rat brain retain their abilities to interact selectively with muscarinic receptor agonists and antagonists. (unboundmedicine.com)
  • As a whole, these studies provide critical new insight for receptor-based drug design of nonsteroidal AR agonists and antagonists. (rcsb.org)
  • According to molecular biological and pharmacological criteria, rat heart membranes normally express only one muscarinic receptor subtype. (nih.gov)
  • Thus, when the intracellular fluid is added back to rat heart membranes, both pirenzepine and AF-DX 116 bind to two receptor sites. (nih.gov)
  • The association and dissociation rates of binding are temperature dependent and fastest at 37 C. Binding is enriched in crude microsomal (P3) membranes. (erowid.org)
  • In the absence of PZ, treatment of cerebral cortical membranes with 20 nM PBCM at 4 degrees C for 50 min resulted in a 69% reduction in the density of M1 binding sites and a 55% reduction in the density of M2 binding sites with no change in the equilibrium dissociation constants of the radioligands [3H]quinuclidinyl benzilate or [3H]PZ. (aspetjournals.org)
  • In radioligand binding experiments using cerebral cortical membranes, PZ inhibited the binding of [3H]quinuclidinyl benzilate in a biphasic manner. (aspetjournals.org)
  • These findings may be explained by the existence of discrete agonist and antagonist states of the alpha receptor, which preferentially bind [ 3 H]clonidine and [ 3 H]WB-4101, respectively. (aspetjournals.org)
  • The Notch receptor is part of a core signalling pathway which is highly conserved in all metazoan species. (nih.gov)
  • After binding of a suitable antigen to the receptor, a signalling pathway is triggered inside the T cell that arms the cell for the respective task. (nanotech-now.com)
  • SUMMARY A direct correlation between HIV infection and mutation in the chemokine receptor ( CCR5 ) gene has been established. (who.int)
  • HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)
  • To test the hypothesis that the putative muscarinic receptor subtypes in rat forebrain are interconvertible states of the same receptor, the selective antagonist pirenzepine (PZ) was used to protect muscarinic receptors from blockade by the irreversible muscarinic receptor antagonist propylbenzilylcholine mustard (PBCM). (aspetjournals.org)
  • Increasing research interest on the selective and sensitive detection of anions has enriched the field of anion receptor chemistry with a wide array of design strategies [15-19] . (beilstein-journals.org)
  • We performed in silico molecular docking and dynamic studies and demonstrated that type and size of substitution at the C17 position of the cortisol backbone confer a unique stable conformation to GR on ligand binding that is critical for inhibitory activity. (oregonstate.edu)
  • Together, our data indicate a model where alteration at position 420 causes a subtle change in E2 conformation that prevents interaction with SR-BI and increases accessibility to the CD81 binding site in-turn favoring a particular internalization route. (gla.ac.uk)
  • Importantly, the cross-neutralizing antibody responses are focused towards conserved RBD epitopes outside of the ACE-2 receptor-binding motif. (biorxiv.org)
  • Severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG antibody levels after AZD1222 vaccination and/or SARS-CoV-2 infection. (ajtmh.org)
  • Incubation of Cry1Ab protoxin with a single chain antibody that mimics the cadherin-like receptor and treatment with Manduca sexta midgut juice or trypsin, resulted in toxin preparations with high pore-forming activity in vitro. (unboundmedicine.com)
  • Engler, O.B., Strasser, I., Naisbitt, D.J., Cerny, A. and Pichler, W.J. (2004) A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. (scirp.org)
  • Differentially changed loci are enriched for sequences resembling ARE half-sites that match the Py-Im polyamide binding preferences determined in vitro. (caltech.edu)
  • This study confirms that the in vivo perturbation pattern caused by a sequence specific polyamide correlates with its in vitro binding preference genome-wide in an unbiased manner. (caltech.edu)
  • The co-receptor CD8 is known to approach the T-cell receptor after antigen binding and to stimulate the transfer of phosphate groups to its intracellular part. (news-medical.net)
  • Our results with E. coli , in conjunction with recent observations made with the yeast Saccharomyces cerevisiae , raise the possibility that the SRP receptor-mediated formation of intracellular membrane networks is governed by evolutionarily conserved principles. (rupress.org)
  • Designing immunogens that elicit broadly neutralizing antibodies to conserved viral epitopes on the major surface glycoprotein, spike, such as the receptor binding domain (RBD) is one potential approach. (biorxiv.org)
  • This activity correlates with the formation of a 250 kDa oligomer that lacks the helix alpha-1 of domain I. The oligomer, in contrast with the 60 kDa monomer, was capable of membrane insertion as judged by 8-anilino-1-naphthalenesulfonate binding. (unboundmedicine.com)
  • It decorates the virus surface and undergoes large conformational changes of its receptor binding domain (RBD) to enter the host cell, as the abundant structural studies suggest. (biorxiv.org)
  • Receptor binding domain-IgG levels correlate with protection in residents facing SARS-CoV-2 B.1.1.7 outbreaks. (bvsalud.org)
  • SARS-CoV-2 receptor-binding domain (RBD) of the S1 subunit (RBD- IgG ) was measured in all residents. (bvsalud.org)
  • Once they had successfully achieved this, the researchers used a trick to fish those receptors out of the preparation that had survived the process and were still functional: due to the strong interaction between the receptor complex and the antigen, they were able to 'fish' one of the most medically important immune receptor complexes. (news-medical.net)
  • Human receptor bound to human H7 HA exits the binding site in a different direction to that seen in complexes formed by HAs from pandemic viruses and from an aerosol-transmissible H5 mutant. (flutrackers.com)
  • The formation of the receptor-anion complexes has been supported by UV-vis titration studies and confirmed through binding constant calculations. (beilstein-journals.org)
  • Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. (cdc.gov)
  • The subsequent images collected at the cryo-electron microscope delivered groundbreaking insights into how the T-cell receptor works, as Tampé summarises: 'On the basis of our structural analysis, we were able to show how the T-cell receptor assembles and recognizes antigens and hypothesize how signal transduction is triggered after antigen binding. (news-medical.net)
  • Researchers led by Lukas Sušac, Christoph Thomas, and Robert Tampé from the Institute of Biochemistry at Goethe University Frankfurt, in collaboration with Simon Davis from the University of Oxford and Gerhard Hummer from the Max Planck Institute of Biophysics, have now succeeded for the first time in visualizing the structure of a membrane-bound T-cell receptor complex with bound antigen. (news-medical.net)
  • Recovery of binding sites was approximately 25% of the initial membrane-bound [3H]QNB binding sites. (unboundmedicine.com)
  • Membrane-bound ribosomes in E. coli were extensively studied over 20 years ago. (rupress.org)
  • Conculsion: In summary, the present study indicates that 17β-estradiol induced up-regulation of apoM in HepG2 cells is through an ER-α-dependent pathway involving ER-α binding element in the promoter of the apoM gene. (lu.se)
  • PGs bind growth factors, regulate proteolytic activity and act as matrix receptors. (lu.se)
  • We have examined the receptor-binding properties of this H7N9 virus and compared them with those of an avian H7N3 virus. (flutrackers.com)
  • The human H7 virus does not, therefore, have the preference for human versus avian receptors characteristic of pandemic viruses. (flutrackers.com)
  • We conclude that the human H7 virus has acquired some of the receptor-binding characteristics that are typical of pandemic viruses, but its retained preference for avian receptor may restrict its further evolution towards a virus that could transmit efficiently between humans, perhaps by binding to avian-receptor-rich mucins in the human respiratory tract rather than to cellular receptors. (flutrackers.com)
  • Although cellular and in vivo studies have provided considerable insight into the downstream consequences of Notch signalling, relatively little is known about the molecular basis of the receptor/ligand interaction and initial stages of activation. (nih.gov)
  • The role of receptor interaction in the process of protoxin activation was analyzed. (unboundmedicine.com)
  • The measured p β Na + are significantly lower than reported for analogous classic anthracene-based Na + , H + -driven AND logic gates indicating a stronger Na + binding interaction, which is attributed to direct interaction with one carbonyl moiety within the aminonaphthalimide. (rsc.org)
  • Furthermore, alteration of this residue modulated the interaction with the SR-BI receptor and changes to these key interactions were found to affect the virus internalization route involving the host co-factor, EGFR. (gla.ac.uk)
  • 1994) T cell receptor V alpha repertoire of infiltrating T cells in labial salivary glands from patients with Sjogren's syndrome. (scirp.org)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • GTP did not alter the interactions of carbachol or oxotremorine with the solubilized receptor. (unboundmedicine.com)
  • Watkins, S.L. and Pichler, W.J. (2013) Activating interactions of sulfanilamides with T cell receptors. (scirp.org)
  • Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 receptor. (gla.ac.uk)
  • Further analyses of mutants with hydrophobic residues (F or Y) found that interactions with receptors SR-BI as well as CD81 were modulated which in-turn determined the viral uptake route. (gla.ac.uk)
  • The p75ECD-binding interface to NT-3 can be divided into three main contact sites, two in the case of NGF, that are stabilized by hydrophobic interactions, salt bridges, and hydrogen bonds. (wikipedia.org)
  • This mechanism was so far assumed to also pertain to the T-cell receptor. (news-medical.net)
  • A comparison of the antigen-bound structure captured using cryo-electron microscopy with that of a receptor without antigen provides the first clues to the activation mechanism. (news-medical.net)
  • Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. (ncbs.res.in)
  • The 1 H NMR titration and TDDFT studies provide full support of the binding mechanism. (beilstein-journals.org)
  • The cryo-EM structure of the fully assembled T-cell receptor (TCR) complex with a tumor-associated peptide/MHC ligand provides important insights into the biology of TCR signaling. (nanotech-now.com)
  • Here we show the first molecular view of reception of a taste substance by a taste receptor, where the binding of the taste substance elicits a different conformational state of T1r2/T1r3 LBD heterodimer. (nature.com)
  • The Hg 2+ and F − ion sensing property of receptor R1 has been utilized to arrive at "AND" and "INHIBIT" molecular logic gate applications. (beilstein-journals.org)
  • For Apt16/RBD complex, molecular dynamic and quantum chemical calculations revealed the pairs of nucleotides and amino acids whose contribution to the binding between aptamer and RBD is the lar gest. (jyu.fi)
  • Step 2: Select AR binding dataset in "Assay Type" at bottom left panel. (fda.gov)
  • SARS-CoV-2 RBD IgG was measured with the Abbott ARCHITECT SARS-CoV-2 IgG II Quant assay with results reported as arbitrary units (AU) per milliliter on the left y -axis and WHO binding international units (bIU) per milliliter on the right y -axis. (ajtmh.org)
  • With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. (lu.se)
  • Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. (ncbs.res.in)
  • We find treatment with this pyrrole-imidazole (Py-Im) polyamide exhibits sequence selectivity in its repression of AR binding in vivo. (caltech.edu)
  • Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model. (oregonstate.edu)
  • Non-invasive imaging of the sigma receptor in vivo would lead to a better understanding of the role that sigma receptors play in health and disease. (umsystem.edu)
  • Previous in vivo studies indicated that unlike the E. coli signal recognition particle (SRP), the SRP receptor FtsY is required for membrane targeting of ribosomes. (rupress.org)
  • Our research identified a novel function of GCs as modulators of tissue regeneration and demonstrated that GCs activate the glucocorticoid receptor (GR) to inhibit early stages of tissue regeneration in zebrafish (Danio rerio). (oregonstate.edu)
  • This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)
  • Assessing indoor dust interference with human nuclear hormone receptors in cell-based luciferase reporter assays. (cdc.gov)
  • 2011) Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. (scirp.org)
  • With the help of cryo-electron microscopy, biochemists and structural biologists from Goethe University Frankfurt, in collaboration the University of Oxford and the Max Planck Institute of Biophysics, were able to visualize the whole T-cell receptor complex with bound antigen at atomic resolution for the first time. (news-medical.net)
  • For the structural analysis, the researchers chose a T-cell receptor used in immunotherapy to treat melanoma and which had been optimized for this purpose in several steps in such a way that it binds its antigen as tightly as possible. (news-medical.net)
  • Due to the lack of structural information of T1r receptors, their functional mechanisms have so far been conjectured from the crystallographic observation on the other class C GPCR members. (nature.com)
  • 2012) Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. (scirp.org)
  • Specific d-LSD binding in forebrain homogenates was unaltered in-rats with lesions in the raphe nuclei. (erowid.org)
  • Recently, it was demonstrated that TCR itself could become reactive by binding to small molecules free of the pHLA interface. (scirp.org)
  • In the first scenario, we assume that the entire surface of the receiver is covered by receptor molecules. (embs.org)
  • Then, in the second scenario, we consider the case where the number of receptor molecules is finite and the uniformly distributed receptor molecules cover the receiver surface only partially. (embs.org)
  • Whilst all mutations reduced E2-CD81 binding, only two (W420A and W420R) reduced HCVcc infectivity. (gla.ac.uk)