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  • peptide
  • Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. (ebi.ac.uk)
  • selective
  • beta(2)AR-mediated EGFR phosphorylation and subsequent beta(2)AR stimulation of extracellular signal-regulated kinase (ERK) 1/2 are sensitive to selective inhibitors of both EGFR and Src kinases, indicating that both kinases are required for EGFR transactivation. (uniprot.org)
  • beta1
  • knocking out of the beta1/2 (show TFAP2B ELISA Kits ) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. (antibodies-online.com)
  • beta2AR
  • S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT- LTP (show SCP2 ELISA Kits )), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C ELISA Kits ) and enhancement of its activity by the beta2-adrenergic receptor ( beta2AR )-cAMP-PKA cascade. (antibodies-online.com)
  • functionally
  • On the basis of our calculations and analysis of other GPCR crystal structures, we suggest that the protonation state of Asp(2.50) may act as a functionally important microswitch in the activation of the beta(2)AR and other class A receptors. (diva-portal.org)
  • GPCR
  • Papers V and VI detail the modeling strategy followed during the GPCR Dock 2013 assessment to blindly predict the structure of two serotonin receptor subtypes (5-HT 1B and 5-HT 2B ) bound to ergotamine. (diva-portal.org)
  • HUMAN
  • Immunohistochemical staining of human prostate specimens showed high expression of beta(2)-AR in glandular, epithelial cells and increased expression in malignant cells compared to benign hyperplasia and normal tissue. (lu.se)
  • adenylyl cyclase
  • This receptor-channel complex also contains a G protein - G s , which activate an adenylyl cyclase , cAMP-dependent kinase , and the counterbalancing phosphatase , PP2A . (enacademic.com)
  • Ligand binding of the B2A receptor leads to the activation of adenylyl cyclase through interaction with the GTP-binding protein Gs. (bio-rad-antibodies.com)
  • airway
  • The beta 2-adrenergic receptor (beta 2AR) signal transduction system regulates many key functions of airway epithelium. (semanticscholar.org)
  • Bronchial smooth muscle possesses #beta2# receptors which causes bronchodilaton (due to relaxation of airway smooth muscle) and also release of allergic mediators are prevented from mast cells due to this #beta2# effect,associated in close relationship with bronchial blood vessels. (socratic.org)
  • Ligand
  • Androgen deprivation is the only effective systemic therapy available for patients with prostatic carcinoma, but is associated with a gradual transition to a hormone-refractory prostate cancer (HRCAP) in which ligand-independent activation of the androgen receptor has been implicated. (lu.se)
  • strongly
  • Interestingly, beta(2)-AR mRNA was strongly down-regulated by androgen ablation therapy of prostate cancer patients. (lu.se)
  • One such residue is the strongly conserved Asp79(2.50), which is buried in a transmembrane cavity and becomes dehydrated upon beta(2)AR activation. (diva-portal.org)
  • activation
  • Activation of Ã?2-Adrenoceptors results in vasodilation, relaxation of the GIT, inhibition of histamine release from mast cells and bronchodilation. (acris-antibodies.com)
  • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. (uniprot.org)
  • We used molecular dynamics (MD) simulations to explore the potential roles of ionizable residues in beta(2)AR activation. (diva-portal.org)
  • MD free energy calculations based on beta(2)AR crystal structures suggested an increase in the population of the protonated state of Asp79(2.50) upon activation, which may contribute to the experimentally observed pH-dependent activation of this receptor. (diva-portal.org)
  • In paper IV, molecular dynamics was used to identify a possible role for a conserved ionizable residue (Asp79 2.50 ) as a protonation switch during the activation process of the β 2 adrenergic receptor. (diva-portal.org)
  • interaction
  • Thus, RTK transactivation is revealed to be a process involving both association of receptors of distinct classes and the interaction of the transactivated RTK with the cells endocytic machinery. (uniprot.org)
  • potent
  • Hence,these #beta2# receptors are potent targets of drugs for relieving acute attack of asthma,which are designed to agonise their effects (like Salbutamol,Formeterol etc. (socratic.org)
  • type 2 diabet
  • 0.85 and no other major disease except for type 2 diabetes, while the controls were 127 healthy subjects, BMI (unav.edu)