Wakefulness-Promoting AgentsReceptors, Adrenergic, alpha-2Antirheumatic AgentsArthritis, RheumatoidReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaAntibodies, MonoclonalImmunoglobulin Galpha 1-AntitrypsinReceptors, Adrenergic, alphaHormone AntagonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsNeurokinin-1 Receptor AntagonistsNarcotic AntagonistsAdrenergic alpha-1 Receptor AntagonistsHistamine H2 AntagonistsInterleukin 1 Receptor Antagonist ProteinRats, Sprague-DawleyHypoxia-Inducible Factor 1, alpha SubunitNicotinic AntagonistsMuscarinic AntagonistsAdrenergic alpha-AntagonistsGABA Antagonistsalpha7 Nicotinic Acetylcholine ReceptorHistamine H1 AntagonistsPurinergic P1 Receptor AntagonistsPiperidinesReceptors, Adrenergic, alpha-1Adrenergic alpha-2 Receptor Antagonists