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  • ligand
  • These values are close to the theoretical binding activity of 15.6 nmol/mg protein for 1 mol of the ligand binding 1 mol of the receptor protein. (cshl.edu)
  • inhibitors
  • Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. (springer.com)
  • neurons
  • Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons. (biomedsearch.com)
  • Taken together, these results suggest that a pool of α(2)-ARs associated with GIRK channels is normally down-regulated (or desensitized) in hcrt/orx neurons to only become available for their inhibition following sleep deprivation. (biomedsearch.com)
  • proteins
  • Both proteins showed typical alpha 2-adrenergic binding characteristics with specific binding activities of 13.85 nmol/mg and 14.17 nmol/mg protein. (cshl.edu)
  • Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. (genecards.org)
  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. (genecards.org)
  • G proteins are composed of 3 units, alpha, beta and gamma. (genecards.org)
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. (genecards.org)
  • rauwolscine
  • 3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. (nih.gov)
  • Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM, KD = 2.5 nM, Bmax = 160 fmol/mg protein) and competition studies indicated that [3H]rauwolscine labeled the alpha 2-receptor. (nih.gov)
  • 125I
  • 125I]PIC binds to the alpha 2B-AR in NG-10815 cell membranes with a Kd of 0.5 +/- 0.1 nM. (biomedsearch.com)
  • 125I]PIC should prove useful in binding assays involving tissues with a low receptor density or in small tissue samples and in studies of cloned and expressed alpha 2-AR. (biomedsearch.com)
  • Effects
  • In the event of side effects dosage is to be reduced to 1/2 caplet 3 times a day, followed by gradual increases to 1 caplet 3 times a day. (rxlist.com)
  • catecholamines
  • In adrenalectomized animals, which have been used to further assess the role of catecholamines, there appears to be a compensatory increase in catecholamine generating enzymes and catecholamines in macrophages, resulting in amplification of the acute inflammatory response via engagement of alpha(2)-adrenoceptors. (biomedsearch.com)
  • correlation
  • To establish a correlation between binding and a biological function, the ability of alpha adrenergic agents to stimulate or inhibit vasoconstriction was quantified in vitro using an isolated perfused kidney preparation. (aspetjournals.org)
  • central
  • The present study was designed to examine the role of central noradrenergic system, especially alpha-2 adrenergic receptors in the action of various anesthetics and analgesics;nitrous oxide 75%, halothane 1.3%, pentobarbital 80mg/kg (ip), and morphine 5mg/kg (iv). (nii.ac.jp)