Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. (fishersci.com)
TNFRSF9, also known as 4-1BB and CD137, is a member of the tumor necrosis factor receptor superfamily (TNFRSF). (biolegend.com)
CusabioProtein Description: Extracellular DomainAlternative Name (s) : CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen. (joplink.net)
CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. (wikipedia.org)
As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes. (wikipedia.org)
CD137 is a type I transmembrane glycoprotein that belongs to the TNF/NGF receptor family. (bdbiosciences.com)
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. (kactusbio.cn)
1)Vinay D S , Kwon B S. 4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy[J]. BMB Reports, 2014, 47(3):122-129. (kactusbio.cn)
CD137 is a type I membrane protein and a member of the TNF receptor superfamily. (adipogen.com)
CD137 (4-1BB), or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), is a promising target for enhancing antitumor immune responses without the autoimmune side effects associated with immunotherapy approaches (1). (biocare.net)
TNFRSF9 (Tumor necrosis factor receptor super family, member 9), also called CD137 and 4-1BB, is a co-stimulatory molecule and is mainly expressed on the surface of T, B, NK and mononuclear cells. (biocytogen.com.cn)
Ligand9
The interaction of TNFRSF9 and its ligand, TNFSF9, leads to the activation of cytotoxic T cells, reactivation of anergic T lymphocytes, and induces T-cell proliferation. (biolegend.com)
Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
[7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)
Recombinant Human 4-1BB ligand receptor is produced by our Mammalian expression system and the target gene encoding Leu24-Gln186 is expressed with a 6His tag at the C-terminus. (bonopusbio.com)
Tumor necrosis fa4
Death receptor 6 ( DR6 ), also known as tumor necrosis factor receptor superfamily member 21 ( TNFRSF21 ), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways. (wikidoc.org)
Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA). (wikipedia.org)
It is encoded by TNFRSF9 (tumor necrosis factor receptor superfamily, member 9). (bdbiosciences.com)
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), as known as OX40 or CD134 is expressed primarily on activated T cells [ 12 ]. (biomedcentral.com)
Tnfsf93
TNFRSF9/TNFSF9 preferentially enhances the expansion of CD8+ T cells rather than CD4+ T cells, through the increase of IL-2Rα (CD25) and IL-2 expressions in CD8+ T cells. (biolegend.com)
In vivo studies with TNFSF9 knockout mice and with the agonistic anti-TNFRSF9 monoclonal antibody showed that TNFRSF9/TNFSF9 interaction keeps optimal CD8 T-cell mediated immune response against viral infections and tumors. (biolegend.com)
TNFSF9 works with TNFRSF9 for the generation of cytotoxic T cells, proliferation of T-cells as well as antigen presentation. (abmgood.com)
Costimulatory receptor1
It is a bidirectional signal transducer which acts as a costimulatory receptor molecule on T lymphocytes. (abmgood.com)
Intro The extracellular calcium-sensing receptor CaSR is definitely a classic seven-transmembrane-spanning G protein-coupled receptor (GPCR) belonging to Family C of the superfamily of GPCRs [1]. (immune-source.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Receptor 172A (GPR172A) in Tissue homogenates, saliva and other biological fluids. (myelisakit.com)
Description: A sandwich ELISA kit for detection of G Protein Coupled Receptor 172A from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human G Protein Coupled Receptor 120 (GPR120) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
Antibody5
What buffer format is "Tnfrsf9 Antibody (OASA00035)" provided in? (avivasysbio.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Insulin Receptor (ISR) in serum, plasma, tissue homogenates and other biological fluids. (tuberculosistest.net)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Insulin Receptor (ISR) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (tuberculosistest.net)
A five-antibody custom, ready-to-go protein panel, with receptor, protease, and viral markers is available through the GeoMx Technology Access Program or for order through Abcam. (bioinnovations.in)
Molecule1
This protein pairs with the receptor molecule IL-12Rβ1 ( IL12RB1 ), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. (wikidoc.org)
IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
The protein encoded by this gene is a subunit of the receptor for IL-23 . (wikidoc.org)
Pathways2
Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation. (rndsystems.com)
Several MYC-induced pathways, such as activation of the p53/ARF pathway, changes in expression, and activity of BCL2 proteins or alterations in death receptor signaling have been linked to apoptosis. (ashpublications.org)
Death Receptor1
Death receptor 6 gets a chemical message and starts a signaling pathway that causes apoptosis, also known as cell death, to occur. (wikidoc.org)
Gene2
The protein encoded by this gene is a member of the TNF-receptor superfamily. (wikidoc.org)
Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
TNFRSF1
Among the TNFRSF members, TNFRSF9 is the most potent inducers of IL-2Rα expression on CD8+ T cells. (biolegend.com)
Recombinant5
No. 750002) is immobilized at 1 μg/mL, biotinylated recombinant human TNFRSF9-Fc chimera binds in a dose-dependent manner with EC 50 range of 0.75 - 3.0 ng/mL. (biolegend.com)
Stability Testing for Biotinylated Recombinant Human TNFRSF9-Fc Chimera. (biolegend.com)
Biotinylated recombinant human TNFRSF9-Fc chimera was aliquoted in PBS, 5% glycerol at 0.2 mg/mL. (biolegend.com)
Recombinant Human 4-1BB/TNFRSF9 Protein is expressed from HEK293 with His tag at the C-Terminus. (kactusbio.cn)
Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
Membrane receptor2
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
[2] The DR6 is an alpha-helical integral membrane receptor protein that shows evidence that it has something to do with the inhibition of blood vessels forming on tumors which would allow them to grow larger. (wikidoc.org)
Ligands1
Interestingly, we observed dysregulation of several ligands of T cell function genes in GBM tissue corresponding to the T-cell receptors that were dysregulated in tumor infiltrating CD4+ T-cells. (oncotarget.com)
Binds1
LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). (amjournals.org)
Human6
The mouse TNFRSF9 has 60% identity to the human receptor at the amino acid level. (biolegend.com)
Human TNFRSF9, amino acid Leu24-Gln186 (Accession # Q07011.1), with a linker (SSLGS), a C-terminal human IgG1 (Pro100-Lys330) and an Avi-tag, was expressed in 293E cells. (biolegend.com)
Human TNFRSF9-Fc Chimera was site-specifically biotinylated by enzyme BirA. (biolegend.com)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
The human interferon-gamma receptor. (wikidoc.org)
A heterogeneous human population of mammalian taste cells includes morphologically and functionally different taste cells classified into three subtypes type I (glial-like cells) type II (receptor cells) and type III (presynaptic) taste cells [16]. (immune-source.com)
Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
[8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
Interleukin-23 receptor is a type I cytokine receptor . (wikidoc.org)
is definitely expressed inside a subset of type II (receptor) and type III (presynaptic) cells Mammalian taste buds contain three unique classes of cells [13]-[15]. (immune-source.com)
These classes express different matches of genes related to their functions: receptor (Type II) cells express G-protein coupled taste receptors and transduction LY 2183240 machinery. (immune-source.com)
RNA targets include COVID-19 receptors and proteases, pulmonary alveolar type I and II markers, lung biology markers, viral response markers, and SARS-CoV-2 probes. (bioinnovations.in)
Biological1
Description: A sandwich quantitative ELISA assay kit for detection of Rat Insulin Receptor (ISR) in samples from serum, plasma, tissue homogenates or other biological fluids. (tuberculosistest.net)
Stimulate1
Utomilumab (PF-05082566) targets this receptor to stimulate a more intense immune system attack on cancers. (wikipedia.org)
Gamma1
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
Apoptosis1
This receptor has been shown to activate NF-κB and MAPK8 / JNK , and induce cell apoptosis . (wikidoc.org)
IL-36alpha, IL-36β, and IL-36gamma (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. (watson-bio.cn)
Biology1
CaSR is normally expressed within a subpopulation of flavor cells in mice and rats [4] [5] recommending potential roles because of this receptor in flavor mobile biology. (immune-source.com)
CaSR-expressing taste cells are a different subset of cells from your T1R3-expressing umami or lovely taste receptor cells. (immune-source.com)
These observations show that CaSR-expressing taste cells are the main detectors of substances and that they are an independent population from your influenced basic taste receptor cells at least in the case of lovely and umami. (immune-source.com)
Activation1
Both α7 and α4β2 nAChRs are found within the somatodendritic regions of interneurons and activation of these receptors prospects to GABA launch onto both pyramidal neurons and interneurons (Alkondon et al. (biosemiotics2013.org)