• A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • 1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. (guidetopharmacology.org)
  • The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. (bvsalud.org)
  • In the article "Endocytosis of the Glutamate Receptor Subunit GluK3 Controls Polarized Trafficking," by Deborah Huyghe, Julien Veran, Virginie F. Labrousse, David Perrais, Christophe Mulle, and Françoise Coussen, which appeared on pages 11645-11654 of the August 10, 2011 issue, the authors found a mistake in the author contributions footnote incorrectly listing V.F.L. and F.C. as having designed research. (jneurosci.org)
  • AMPA receptors are tetrameric glutamate‐gated ion channels that mediate a majority of fast excitatory neurotransmission in the brain. (ucl.ac.uk)
  • In addition, metabotropic glutamate receptors (brain and taste variants of mGluR1 and mGluR4) are thought to function as umami taste receptors. (elsevierpure.com)
  • One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivation of glutamate receptors leading to intracellular Ca(2+) overload and ultimately neuronal demise. (bordeaux-neurocampus.fr)
  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. (nih.gov)
  • This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. (nih.gov)
  • Editing of mRNA in the coding region of the second transmembrane domain of glutamate receptor subunits GluR2, GluR5, and GluR6 involves a change of the base A in genomic DNA to the base G in mRNA as described in rat brain. (johnshopkins.edu)
  • Paschen, W, Hedreen, JC & Ross, CA 1994, ' RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue ', Journal of Neurochemistry , vol. 63, no. 5, pp. 1596-1602. (johnshopkins.edu)
  • In the mammalian retina, rod photoreceptors form selective contacts with rod ON-bipolar cells by aligning the presynaptic voltage-gated Ca 2+ channel directing glutamate release (Ca V 1.4) with postsynaptic mGluR6 receptors. (nih.gov)
  • GABA(A) receptors are ligand-operated chloride channels assembled from five subunits in a heteropentameric manner. (nih.gov)
  • Using immunocytochemistry, we investigated the distribution of GABA(A) receptor subunits deriving from 13 different genes (alpha1-alpha6, beta1-beta3, gamma1-gamma3 and delta) in the adult rat brain. (nih.gov)
  • In this study, a highly heterogeneous distribution of 13 different GABA(A) receptor subunit-immunoreactivities was observed. (nih.gov)
  • This distribution and the apparently typical patterns of co-distribution of these GABA(A) receptor subunits support the assumption of multiple, differently assembled GABA(A) receptor subtypes and their heterogeneous distribution within the adult rat brain. (nih.gov)
  • Fast inhibition in the nervous system is commonly mediated by GABA A receptors comprised of 2α/2β/1γ subunits. (jneurosci.org)
  • In contrast, GABA C receptors containing onlyρ subunits (ρ1-ρ3) have been predominantly detected in the retina. (jneurosci.org)
  • Responses to GABA C agonists were also enhanced by the GABA A receptor modulator pentobarbitone (300 μM). (jneurosci.org)
  • We therefore tested the hypothesis that GABA A and GABA C subunits formed a heteromeric receptor. (jneurosci.org)
  • Electrophysiology revealed that responses to GABA C receptor agonists were enhanced by the GABA A receptor modulator zolpidem (500 n m ), which acts on the α1 subunit when the γ2 subunit is also present. (jneurosci.org)
  • Taken together these separate lines of evidence suggest that the effects of GABA in central neurons can be mediated by heteromeric complexes of GABA A and GABA C receptor subunits. (jneurosci.org)
  • Fast inhibition in the CNS is principally mediated by the neurotransmitter GABA acting on GABA A and GABA C ionotropic receptors ( Macdonald and Olsen, 1994 ). (jneurosci.org)
  • A new γ-aminobutyric acid (GABA) A receptor (GABAR) subunit class, ε, has recently been cloned and shown to form functional channels when coexpressed with both α and β subunits. (aspetjournals.org)
  • We report that the combination of α1β3ε subunit subtypes expressed in L929 cells produced functional chloride ion channels that were both spontaneously active and gated by the application of extracellular GABA. (aspetjournals.org)
  • These data extend the pharmacological characterization of ε-containing GABARs and demonstrate that incorporation of the ε subunit permits spontaneous channel gating while preserving the structural information necessary for GABA sensitivity. (aspetjournals.org)
  • A number of compounds that bind to the benzodiazepine site potentiated the GABA response of alpha 6 beta 2 gamma 2 receptors. (drugbank.com)
  • An impairment of GABA(A)-receptor-mediated inhibitory neurotransmission has been implicated in the development of epileptic seizures. (psu.edu)
  • To determine whether seizures affect GABA(A)-receptor gene transcription in vivo, a transgenic mouse line carrying a lacZ-fusion gene driven by GABA(A)-receptor δ-subunit promoter and upstream sequences was subjected to pentylenetetrazol (PTZ)-induced seizures. (psu.edu)
  • These results show that transient changes in transcription of the GABA(A)-receptor δ-subunit gene occur after acute seizures, but not after kindling. (psu.edu)
  • The limited responsiveness of the GABA(A)-receptor δ-subunit promoter after repeated stimulation may reflect an inappropriate adaptation of cellular responses to recurrent excitation, thereby contributing to the development of seizure. (psu.edu)
  • Fast inhibition in the nervous system is commonly mediated by GABA(A) receptors comprised of 2alpha/2beta/1gamma subunits. (ox.ac.uk)
  • In contrast, GABA(C) receptors containing only rho subunits (rho1-rho3) have been predominantly detected in the retina. (ox.ac.uk)
  • The type A gamma-aminobutyric acid (GABA A ) receptor plays a major inhibitory role in the central nervous system. (edu.hk)
  • In order to develop better drugs targeting this receptor, the detailed three-dimensional structure of GABA A receptor is needed to be determined. (edu.hk)
  • Hence, an over-expressed 131-residue extracellular membrane-proximal fragment of GABA A receptor αl subunit, Cys166-Leu296, which harbors most of the important ligand-binding sites, was chosen to study. (edu.hk)
  • Nonbenzodiazepine receptor agonists have a nonbenzodiazepine structure and bind more specifically to the alpha-1 subunit of the gamma-aminobutyric acid-A (GABA A ) receptor, which is associated with sedation. (medscape.com)
  • By binding to specific subunits of GABA A receptor sites, these agents appear to potentiate the effects of GABA and facilitate inhibitory GABA neurotransmission by increasing the frequency of chloride channel opening. (medscape.com)
  • Reduction in the expression or function of α5-subunit-containing GABAA receptors (α5GABAARs) leads to improvement in several hippocampus-dependent memory domains. (uzh.ch)
  • A cDNA encoding the human gamma-aminobutyric acidA (GABAA) receptor alpha 6 subunit has been cloned and sequenced. (drugbank.com)
  • Recombinant human alpha 6 beta gamma 2S GABAA receptors have been expressed in both stably transfected cells and Xenopus oocytes, and the pharmacology of the benzodiazepine binding site has been determined. (drugbank.com)
  • Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. (ox.ac.uk)
  • However, here using reverse transcription-PCR and in situ hybridization we show that mRNA encoding the ρ1 subunit is highly expressed in brainstem neurons. (jneurosci.org)
  • Using a monospecific antibody raised to the human placental fibronectin receptor complex, we found that TGF-.beta.1 stimulated fibronectin receptor synthesis up to 20-40-fold and increase mRNA levels encoding both the .alpha. (eurekamag.com)
  • Actinomycin D blocks TGF-.beta.1-mediated increases in receptor mRNA levels. (eurekamag.com)
  • mediated increases in fibronectin receptor complex protein synthesis and mRNA levels occur at 8 h, whereas the earliest increases in fibronectin protein synthesis and mRNA levels occur at 12 h. (eurekamag.com)
  • with flanking intron sequences of 105 nucleotides on the 3' end, and of 70 nucleotides on the 5' end) of the alpha subunit of the chicken muscle acetylcholine receptor gene, we were able to quantitate the concentration of mature alpha subunit mRNA and its precursor. (rupress.org)
  • The PCR product was incubated with the restriction enzyme BbvI, which recognizes the sequence GCAGC present in the nonedited sequence of the mRNA in subunits GluR2 and GluR6. (johnshopkins.edu)
  • As in the rat, the GluR2 subunit mRNA was completely edited in human brain. (johnshopkins.edu)
  • Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. (drugbank.com)
  • Hwang, J & Menon, KMJ 1984, ' Characterization of the subunit structure of gonadotropin receptor in luteinized rat ovary ', Journal of Biological Chemistry , 卷 259, 編號 3, 頁 1978-1985. (tmu.edu.tw)
  • Menon, K. M J. / Characterization of the subunit structure of gonadotropin receptor in luteinized rat ovary . (tmu.edu.tw)
  • These findings suggest that an accelerated rate of transcription of the message coding for the alpha subunit causes increased message content and the stimulation of receptor synthesis characteristic of denervated muscle. (rupress.org)
  • A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. (wikidata.org)
  • Nicotinic acetylcholine receptors regulate the nicotine dependence encountered with cigarette smoking, and this has stimulated a search for drugs binding the responsible receptor subtypes. (rti.org)
  • They exist as calcium‐impermeable (CI‐) and calcium‐permeable (CP‐) subtypes, the latter of which lacks the GluA2 subunit. (ucl.ac.uk)
  • This observation demonstrates definitively that efficacy of benzodiazepine compounds cannot be generalized across receptor subtypes and may also help explain some of the behavioral effects that have been reported for these compounds. (drugbank.com)
  • Furthermore, while differential effects manifest after several days of chronic stimulation, changes to receptor structure, orientation, or stoichiometry have not elucidated the cause for differential signaling via different type I IFN subtypes. (wikidoc.org)
  • Structural analysis of type I IFN receptor with different type I IFN ligand subtypes revealed a similar binding site for the different agonists. (wikidoc.org)
  • [8] The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses. (wikidoc.org)
  • The physiology and pharmacology of the hair cell receptor is identical to that of the α9/10 receptor expressed in Xenopus oocytes. (frontiersin.org)
  • The recombinant receptor has a diazepam-insensitive pharmacology, with negligible affinity for a number of classic benzodiazepines. (drugbank.com)
  • There is an emerging literature that the distribution of the α9 and α10 subunits in peripheral tissues is widespread and non-synaptic, regulated in disease states, and may not always be assembled as heteromeric receptors. (frontiersin.org)
  • By coexpression of wild-type P2X 3 and mutated P2X 2 subunit, we found that the heteromeric P2X 2/3 channel functioned normally when either lysine in the P2X 2 subunit was mutated to alanine (i.e. (aspetjournals.org)
  • The rescue of the single lysine mutant P2X 2 subunit by wild-type P2X 3 (but not the converse) suggests that the heteromeric channel contains one P2X 2 and two P2X 3 subunits and that the receptor functions essentially normally as long as two subunits are not mutated. (aspetjournals.org)
  • The adult form of the GlyR is the heteromeric α 1 β receptor, which is believed to have a stoichiometry (proportion) of three α 1 subunits and two β subunits [3] or four α 1 subunits and one β subunit. (bionity.com)
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant ß Subunits Acquire Sensitivity to α 7-Selective Positive Allosteric Modulators. (bvsalud.org)
  • The failure to rescue function in the P2X 2 subunit with both lysines mutated by wild-type P2X 3 suggests that these residues from two different subunits interact in agonist binding or channel opening. (aspetjournals.org)
  • [ 17 ] and a short course of a sedative-hypnotic or melatonin receptor agonist. (medscape.com)
  • Medications used in the treatment of insomnia include nonbenzodiazepine receptor agonists, benzodiazepine receptor agonists, the selective melatonin receptor agonist ramelteon, and sedating antidepressants. (medscape.com)
  • Currently, ramelteon is the only melatonin receptor agonist approved by the FDA for treatment of insomnia and is available by prescription. (medscape.com)
  • The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. (eurekamag.com)
  • In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus accumbens (NAc) NMDA receptor expression and function underlies the propensity for high or low motivation to voluntarily wheel-run. (eurekamag.com)
  • Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia. (bordeaux-neurocampus.fr)
  • NMDA receptor structures reveal subunit arrangement and pore architecture. (expasy.org)
  • However, immunocytochemistry reveals that the same region exhibits a 28% increase in the proportion of spines labeled for the NR2A subunits of NMDA receptors (NMDAR), with a 31% increase specifically at postsynaptic densities and a concomitant reduction of these subunits at nonsynaptic sites within spine heads. (nyu.edu)
  • Recent evidence suggests a functional interaction of the subunits and potentially a structural association. (frontiersin.org)
  • This complex interaction of the subunits leads to a preferential stabilization of states with zero, two or four ligands and suggests a dimeric organization of the activation process: within the dimers the cooperativity is positive, whereas it is negative between the dimers. (nature.com)
  • However, coexpression of wild-type P2X 2 with a mutated P2X 3 subunit ([K68A] or [K299A]) produced no functional heteromers. (aspetjournals.org)
  • Here we summarise the functional hallmarks of CP‐AMPARs and describe how these are modified by the presence of auxiliary subunits that have emerged as pivotal regulators of AMPARs. (ucl.ac.uk)
  • A functional GABAC receptor is composed of __________ subunits. (physiologyweb.com)
  • Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. (wikidata.org)
  • [4] The α-subunits are also able to form functional homo-pentameric receptors in heterologous expression systems in African clawed frog's oocytes or mammalian cell lines, [4] and the α 1 homomeric receptor is essential for studies of channel pharmacokinetics and pharmacodynamics . (bionity.com)
  • The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (lu.se)
  • Nicotinic acetylcholine receptors (nAChRs) are ion-gated channels that have diverse function in nervous and non-nervous tissues. (frontiersin.org)
  • Studies link a gene cluster encoding for alpha 3 beta 4 alpha 5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence. (rti.org)
  • Clones were assessed for plasma membrane expression of the individual receptor subunits by mass spectrometry and immunochemistry, and their calcium flux was measured in the presence of a library of kinase inhibitors and a focused library of acetylcholine receptor ligands. (rti.org)
  • Hit compounds from both libraries suggest the alpha 5 and alpha 5-D398N subunits allosterically modify the behavior of nicotine at the parent alpha 3 beta 4 nicotinic acetylcholine receptor. (rti.org)
  • Quantitation of an alpha subunit splicing intermediate: evidence for transcriptional activation in the control of acetylcholine receptor expression in denervated chick skeletal muscle. (rupress.org)
  • We have investigated the mechanisms responsible for the increase in acetylcholine receptor subunit mRNAs during the induction of denervation supersensitivity in skeletal muscle. (rupress.org)
  • A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family . (online-medical-dictionary.org)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice. (bvsalud.org)
  • SRP receptor alpha subunit is a protein that in humans is encoded by the SRPRA gene. (wikipedia.org)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. (bvsalud.org)
  • abstract = "Determining the precise subunit composition of AMPARs in situ has been an enduring challenge. (johnshopkins.edu)
  • abstract = "The T1R1 receptor subunit acts as an umami taste receptor in combination with its partner, T1R3. (elsevierpure.com)
  • The receptor can be activated by a range of simple amino acids including glycine , β-alanine and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine . (bionity.com)
  • It detects human Interferon-α Receptor, Type I, Subunit I (Ser535,539) and is antigen affinity purified from pooled serum. (phosphosolutions.com)
  • [7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
  • IFNAR1 is the low affinity subunit, originally cloned in 1990, and is composed of four fibronectin type II-like (FNII-like) subdomains, termed SD1-4. (wikidoc.org)
  • Interleukin-2 (IL-2) binds to both high- and low-affinity classes of IL-2 receptors on activated T lymphocytes. (agri.gov.il)
  • however, the structural features distinguishing the high- and low-affinity receptors are unknown. (agri.gov.il)
  • This band was not present when IL-2 was cross-linked to transfected C127 cells, which exclusively express low-affinity receptors. (agri.gov.il)
  • The data presented are most consistent with the existence of a 70- to 77-kilodalton glycoprotein subunit (p70) which, upon associating with the 55-kilodalton low-affinity receptor (p55), transforms it into a high-affinity site. (agri.gov.il)
  • It is proposed that p55 and p70 be referred to as the α and β subunits, respectively, of the high-affinity IL-2 receptor. (agri.gov.il)
  • Gonadotropin receptors with specificity, high affinity and low capacity for luteinizing hormone and human chorionic gonadotropin (hCG) have been identified in rat luteal cells. (tmu.edu.tw)
  • Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
  • There are presently four known isoforms of the α-subunit (α 1-4 ) of GlyR that are essential to bind ligands ( GLRA1 , GLRA2 , GLRA3 , GLRA4 ) and a single β-subunit ( GLRB ). (bionity.com)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. (phosphosolutions.com)
  • We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
  • The glycine receptor , or GlyR , is the receptor for the amino acid neurotransmitter glycine . (bionity.com)
  • It uses material from the Wikipedia article "Glycine_receptor" . (bionity.com)
  • These subunits are the most recently discovered (and perhaps the last to be discovered) nAChR subunits in mammals, but are phylogenetically the oldest. (frontiersin.org)
  • Immunohistochemistry localized the ρ1 subunit to neurons at light and electron microscopic levels, where it was detected at synaptic junctions. (jneurosci.org)
  • METHODS: Using immunoprecipitation from neuronal cultures and tandem mass spectrometry, we identified antibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAAR) in a patient whose immunoglobulin G (IgG) antibodies bound to hippocampal neurons. (ox.ac.uk)
  • After injection of a single convulsive dose of PTZ, the activity of the δ-subunit promoter, as monitored by β-galactosidase immunohistochemistry, was increased selectively in neurons of layers II-IV of neocortex. (psu.edu)
  • Quantum dots have been used to track the diffusion of glycine receptors into the synapse of neurons. (bionity.com)
  • The channels are primarily activated by voltage but are receptors as well, binding the intracellular ligand cyclic AMP. (nature.com)
  • Strychnine-sensitive glycine receptors are members of a family of Ligand-gated ion channels . (bionity.com)
  • Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. (wikidoc.org)
  • Ligand binding to either subunit is required for and precedes dimerization and activation of the receptor. (wikidoc.org)
  • Each subunit of IFNAR contains an N-terminal ligand binding domain (with two or four fibronectin type II-like subdomains, for IFNAR2 and IFNAR1, respectively), a transmembrane (TM) domain, and a cytoplasmic domain. (wikidoc.org)
  • IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
  • Both eszopiclone and sustained-release zolpidem are effective for both sleep-onset and sleep-maintenance insomnia, with a reduced abuse potential and long-term efficacy of up to 6 months as compared with nonselective benzodiazepine receptor agonists. (medscape.com)
  • Short-acting (eg, triazolam) and intermediate-acting (eg, estazolam, temazepam) benzodiazepine receptor agonists are useful for sleep-onset insomnia. (medscape.com)
  • The remaining 60% had lower antibody titers (p = 0.0005), which were mainly immunoglobulin M (IgM) (p = 0.0025), and showed no defined subunit specificity. (ox.ac.uk)
  • In our previous studies in vivo , we have found that the Fc receptors appear to have a key role in α-SYN-induced inflammation: deficiency of FcγRs blocks α-SYN-induced NF-κB-driven pro-inflammatory signaling, and attenuates microglial activation and DA neurodegeneration [ 15 ]. (biomedcentral.com)
  • Due to the controversy regarding the differential role of GluN2A and GluN2B subunits in excitotoxic cell death, we investigated the role of GluN2B in the activation of pro-death signaling following an in vitro model of global ischemia, oxygen and glucose deprivation (OGD). (bordeaux-neurocampus.fr)
  • Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene. (agri.gov.il)
  • Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE. (bvsalud.org)
  • In a Herculean effort, they provide the field with the completeness of a pie chart outlining the contribution of each AMPAR subunit to basal synaptic transmission at CA1 hippocampus synapses-and we get a pie chart for somatic extrasynaptic receptors, too. (johnshopkins.edu)
  • GluN2B subunits. (bordeaux-neurocampus.fr)
  • Notably, we found a crucial role of the C-terminal domain of the GluN2B subunit in triggering excitotoxic signaling. (bordeaux-neurocampus.fr)
  • Taken together, our results identify crucial determinants in the C-terminal domain of GluN2B subunits in promoting neuronal death in ischemic conditions. (bordeaux-neurocampus.fr)
  • The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. (wikipedia.org)
  • We also have observed that Fcγ receptors (FcγR), proteins present on the surface of microglia that bind immunoglobulin G (IgG) and other ligands, are key modulators of α-SYN-induced neurodegeneration. (biomedcentral.com)
  • Fc gamma receptors (FcγR) are proteins expressed on the surface of microglia as well as other cell types, including natural killer cells, neutrophils, and mast cells. (biomedcentral.com)
  • Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
  • In this study, we describe the development of homogeneous HEK-293 cell clones of alpha 3 beta 4 and alpha 3 beta 4 alpha 5 receptors appropriate for drug screening and characterizing biochemical and pharmacological properties of incorporated alpha 5 subunits. (rti.org)
  • We demonstrated an incorporation of two alpha 3 subunits in approximately 98% of plasma membrane receptor pentamers, indicating a 2/3 subunit expression ratio of alpha 3 to beta 4 alone or to coexpressed beta 4 and alpha 5. (rti.org)
  • With prolonged nicotine exposure, the plasma membrane expression of receptors with and without incorporated alpha 5 increased. (rti.org)
  • Whereas alpha 5 subunit expression decreased the cell calcium response to nicotine and reduced plasma membrane receptor number, it partially protected receptors from nicotine mediated desensitization. (rti.org)
  • It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
  • In 3-wk-old chicks, the concentration of alpha subunit message in leg muscle was found to be 4.0 attomoles per microgram total RNA, and to increase 40-fold within 1 wk after section of the sciatic nerve. (rupress.org)
  • The deduced amino acid sequence of this cDNA shows 91.4% identity with the published rat alpha 6 subunit. (drugbank.com)
  • Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone (dataset). (cdc.gov)
  • We recorded membrane currents from human embryonic kidney cells expressing P2X subunits and found that lysine-to-alanine substitutions at equivalent positions in the P2X 3 receptor (Lys 63 and Lys 299 ) also prevented channel function. (aspetjournals.org)
  • Because cells communicate with several extracellular matrix components via specific cell membrane receptors, we hypothesized that TGFs-.beta. (eurekamag.com)
  • The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
  • The alpha5-subunit-immunoreactivity was strongest in Ammon's horn, the olfactory bulb and hypothalamus. (nih.gov)
  • subunit alpha1- and alpha5-immunoreactivities were about equally distributed in both areas. (nih.gov)
  • In the supraoptic nucleus, staining of conspicuous dendritic networks with subunit alpha1, alpha2, beta2, and gamma2 antibodies was contrasted by perykarya labeled for alpha5-, beta1- and delta-immunoreactivities. (nih.gov)
  • The appearance of the cross-linked 125 I-hCG·receptor was effectively inhibited by the unlabeled β-subunit of hCG, intact hCG, and luteinizing hormone and partially inhibited by the α-subunit of hCG but not by choleratoxin, gonadotropin-releasing hormone, insulin or bovine serum albumin. (tmu.edu.tw)
  • Subunit alpha1-, beta1-, beta2-, beta3- and gamma2-immunoreactivities were found throughout the brain, although differences in their distribution were observed. (nih.gov)
  • In contrast, labeling for the alpha1-, beta2-, gamma1- and gamma2-subunits prevailed in the pallidum compared to the striatum. (nih.gov)
  • With the exception of the reticular thalamic nucleus, which was prominently stained for subunits alpha3, beta1, beta3 and gamma2, most thalamic nuclei were rich in alpha1-, alpha4-, beta2- and delta-immunoreactivities. (nih.gov)
  • In most pontine and cranial nerve nuclei and in the medulla, only subunit alpha1-, beta2- and gamma2-immunoreactivities were strong, whereas the inferior olive was significantly labeled only for subunits beta1, gamma1 and gamma2. (nih.gov)
  • Immunohistochemistry indicated that rho1 and alpha1 subunits were colocalized at light and electron microscopic levels. (ox.ac.uk)
  • Molecular cloning of the zeta chain of the T cell antigen receptor. (wikidata.org)
  • Receptors of this family are arranged as five subunits surrounding a central pore, with each subunit composed of four α helical transmembrane segments. (bionity.com)
  • The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. (nih.gov)
  • These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). (phosphosolutions.com)
  • It is one of the most widely distributed inhibitory receptors in the central nervous system . (bionity.com)
  • This Research Topic presents the current state of basic research activities on the function of α9 and a10 receptors, ideas about their roles in basic biology, physiology and inflammation and animal models for analysis of functions, and human disease states. (frontiersin.org)
  • The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
  • coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
  • Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. (nih.gov)
  • The α9 and α10 subunits are not expressed in the mammalian brain, making them unique among nAChRs. (frontiersin.org)
  • Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)
  • In contrast, no change in levels or the distribution pattern of NR2B subunit levels were detected within spine heads. (nyu.edu)
  • Differentiation into Th1 depends on the presence of IFN-γ and IL-12, which bind to receptors on the surface of CD4 T cells 5 . (bvsalud.org)
  • The α9 and α10 subunits are members of the subfamily I, epithelial ion-gated nicotinic receptor gene family. (frontiersin.org)
  • The GluR6 subunit was nearly completely edited in all gray matter structures investigated including cortex, striatum, thalamus, hippocampus, amygdala, and cerebellum with extent of editing ranging from 89% in the cerebellum to 95% in the cortex and striatum. (johnshopkins.edu)
  • Our Anti-Interferon-α Receptor, Type I, Subunit I (Ser535,539) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. (phosphosolutions.com)
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • Subunit alpha6-immunoreactivity was only present in granule cells of the cerebellum and the cochlear nucleus, and subunit gamma1-immunoreactivity was preferentially located in the central and medial amygdaloid nuclei, in pallidal areas, the substantia nigra pars reticulata and the inferior olive. (nih.gov)
  • Positive Darwinian evolutionary changes in the mammalian α10 subunit resulted in increased calcium permeability and parallels the evolution of the anion chloride transporter SLC26A5 (prestin) and somatic electromotility in cochlear OHCs. (frontiersin.org)
  • Subunit delta-immunoreactivity was frequently co-distributed with alpha4 subunit-immunoreactivity, e.g. in the thalamus, striatum, outer layers of the cortex and dentate molecular layer. (nih.gov)
  • Despite the recent upsurge in research interest in these subunits, there is much unknown about their functions and the underlying molecular mechanisms. (frontiersin.org)
  • This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. (guidetomalariapharmacology.org)
  • The molecular weight of 125 I-hCG-linked receptor complex and the receptor subunit structure were determined by electrophoresis in either 10 or 4.5% acrylamide in the presence of 0.1% sodium dodecyl sulfate with or without reducing agents. (tmu.edu.tw)