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Anatomy25

Adipocytes Muscle, Skeletal Cell Line 3T3 Cells Liver Cells, Cultured CHO Cells 3T3-L1 Cells Islets of Langerhans Cell Membrane Adipose Tissue Tumor Cells, Cultured Insulin-Secreting Cells COS Cells Cell Line, Tumor Subcellular Fractions Fibroblasts Hep G2 Cells Brain Muscle Fibers, Skeletal Muscles Hepatocytes Adipose Tissue, Brown Hypothalamus Neurons

Organisms11

Mice, Knockout Cricetinae Escherichia coli Rats, Wistar Mice, Inbred C57BL Rats, Zucker Rats, Sprague-Dawley Cattle Mice, Obese Mice, Transgenic Saccharomyces cerevisiae

Diseases12

Insulin Resistance Diabetes Mellitus, Type 2 Hyperinsulinism Obesity Glucose Intolerance Hyperglycemia Diabetes Mellitus, Experimental Disease Models, Animal Cell Transformation, Neoplastic Breast Neoplasms Body Weight Diabetes Mellitus

Chemicals and Drugs113

Insulin Receptor Substrate Proteins Phosphoproteins Receptor, Insulin Insulin Phosphatidylinositol 3-Kinases Intracellular Signaling Peptides and Proteins Tyrosine Proto-Oncogene Proteins c-akt Glucose Receptor, IGF Type 1 Phosphotyrosine Phosphotransferases (Alcohol Group Acceptor)Adaptor Proteins, Signal Transducing Glucose Transporter Type 4 Insulin-Like Growth Factor I GRB2 Adaptor Protein Protein-Serine-Threonine Kinases Monosaccharide Transport Proteins Serine Recombinant Proteins Proto-Oncogene Proteins Proteins Protein Tyrosine Phosphatases Protein Tyrosine Phosphatase, Non-Receptor Type 11 Androstadienes Deoxyglucose Ribosomal Protein S6 Kinases Phosphoserine Protein-Tyrosine Kinases Muscle Proteins Shc Signaling Adaptor Proteins Protein Tyrosine Phosphatase, Non-Receptor Type 1 Enzyme Inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 6 Ribosomal Protein S6 Kinases, 70-kDa TOR Serine-Threonine Kinases Recombinant Fusion Proteins Isoenzymes Carrier Proteins Protein Kinases Calcium-Calmodulin-Dependent Protein Kinases Phosphatidylinositol 3-Kinase Glycogen Synthase Kinase 3 Hypoglycemic Agents Blood Glucose Glycogen Adaptor Proteins, Vesicular Transport Mitogen-Activated Protein Kinases Insulin Antagonists STAT6 Transcription Factor Chromones Protein Kinase C DNA, Complementary Membrane Proteins Morpholines Glycogen Synthase Kinases Phosphotransferases Receptor Protein-Tyrosine Kinases Phosphopeptides RNA, Messenger DNA Primers SH2 Domain-Containing Protein Tyrosine Phosphatases Suppressor of Cytokine Signaling Proteins Threonine Glutathione Transferase Proteasome Endopeptidase Complex Glucose Transporter Type 1 JNK Mitogen-Activated Protein Kinases Janus Kinase 2 Extracellular Signal-Regulated MAP Kinases DNA RNA, Small Interfering Glucokinase Leptin Receptors, Interleukin-4 Protein Isoforms Bacterial Proteins Macromolecular Substances Adenosine Triphosphate Dietary Fats Multiprotein Complexes Janus Kinase 1 Transcription Factors Trans-Activators Epidermal Growth Factor Interleukin-4 Fatty Acids, Nonesterified Mitogen-Activated Protein Kinase 1 Glycogen Synthase Sirolimus Mitogens Oncogene Protein v-akt Nerve Tissue Proteins Escherichia coli Proteins Endopeptidases Peptides Mitogen-Activated Protein Kinase 3 Oligopeptides DNA-Binding Proteins Amino Acids Forkhead Transcription Factors Receptors, Leptin AMP-Activated Protein Kinases Receptor, Epidermal Growth Factor NAD Mitogen-Activated Protein Kinase Kinases Oxidoreductases Mixed Function Oxygenases Serine Endopeptidases Cytochrome P-450 Enzyme System Actins Adenosine Triphosphatases Tumor Necrosis Factor-alpha

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Precipitin Tests Immunoblotting Models, Molecular Transfection Models, Biological Mutagenesis, Site-Directed Blotting, Western Immunoprecipitation Cloning, Molecular Crystallography, X-Ray Sequence Alignment Electrophoresis, Polyacrylamide Gel Amino Acid Substitution Obesity Glucose Tolerance Test Glucose Clamp Technique Gene Knockdown Techniques Diabetes Mellitus, Experimental Models, Chemical Reverse Transcriptase Polymerase Chain Reaction Disease Models, Animal Chromatography, High Pressure Liquid Enzyme Stability Reference Values Chromatography, Gel Body Weight

Phenomena and Processes56

Substrate Specificity Phosphorylation Signal Transduction Insulin Resistance Kinetics Amino Acid Sequence Enzyme Activation Binding Sites Protein Binding src Homology Domains Catalysis Base Sequence Biological Transport Sequence Homology, Amino Acid Transfection Mutation Protein Structure, Tertiary Hydrolysis Structure-Activity Relationship Catalytic Domain Hydrogen-Ion Concentration Time Factors Protein Transport Protein Conformation Cell Division Dose-Response Relationship, Drug MAP Kinase Signaling System Gene Expression Regulation Amino Acid Substitution Down-Regulation Oxidation-Reduction Obesity Protein Processing, Post-Translational Homeostasis Cell Differentiation Gene Expression RNA Interference Molecular Structure Cell Proliferation Gluconeogenesis Gene Expression Regulation, Enzymologic Apoptosis Stereoisomerism Molecular Weight Substrate Cycling Temperature Phenotype Enzyme Stability Organ Specificity Longevity Lipid Metabolism Cell Survival Protein Structure, Secondary Up-Regulation Amino Acid Motifs Body Weight

Technology, Industry, Agriculture1

Information Science3

Molecular Sequence Data Amino Acid Sequence Base Sequence

Health Care1

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Technology, Industry, Agriculture Information Science Health Care

Insulin Receptor Substrate Proteins Phosphoproteins Receptor, Insulin Insulin Substrate Specificity Phosphatidylinositol 3-Kinases Intracellular Signaling Peptides and Proteins Phosphorylation Signal Transduction Tyrosine Insulin Resistance Proto-Oncogene Proteins c-akt Glucose Receptor, IGF Type 1 Phosphotyrosine Molecular Sequence Data Phosphotransferases (Alcohol Group Acceptor)Kinetics Adaptor Proteins, Signal Transducing Amino Acid Sequence Glucose Transporter Type 4 Adipocytes Enzyme Activation Insulin-Like Growth Factor I GRB2 Adaptor Protein Binding Sites Protein-Serine-Threonine Kinases Protein Binding Muscle, Skeletal Cell Line Monosaccharide Transport Proteins 3T3 Cells Serine Recombinant Proteins Liver Proto-Oncogene Proteins Proteins Protein Tyrosine Phosphatases Precipitin Tests Protein Tyrosine Phosphatase, Non-Receptor Type 11 Mice, Knockout Androstadienes src Homology Domains Deoxyglucose Ribosomal Protein S6 Kinases Cells, Cultured Catalysis CHO Cells Phosphoserine Protein-Tyrosine Kinases Base Sequence Biological Transport Immunoblotting Sequence Homology, Amino Acid Muscle Proteins Shc Signaling Adaptor Proteins Cricetinae Models, Molecular Transfection Protein Tyrosine Phosphatase, Non-Receptor Type 1 Mutation Enzyme Inhibitors Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 6 Models, Biological Ribosomal Protein S6 Kinases, 70-kDa TOR Serine-Threonine Kinases Mutagenesis, Site-Directed Recombinant Fusion Proteins Isoenzymes Hydrolysis Carrier Proteins Blotting, Western Structure-Activity Relationship Escherichia coli Protein Kinases Catalytic Domain Calcium-Calmodulin-Dependent Protein Kinases Phosphatidylinositol 3-Kinase Glycogen Synthase Kinase 3 Hypoglycemic Agents Blood Glucose Diabetes Mellitus, Type 2 Glycogen Adaptor Proteins, Vesicular Transport Rats, Wistar Mitogen-Activated Protein Kinases Hydrogen-Ion Concentration Immunoprecipitation Cloning, Molecular Insulin Antagonists 3T3-L1 Cells STAT6 Transcription Factor Time Factors Mice, Inbred C57BL Chromones Protein Kinase C Crystallography, X-Ray DNA, Complementary Protein Transport

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