Receptor stromal cells. Medical search. Frequent questions

Here, we report that pharmacologic inhibition of A2BR with PSB1115, which inhibits tumor growth, decreased the number of fibroblast activation protein (FAP)-expressing cells in tumors in a mouse model of melanoma. (unisa.it)
In lung cancer, platelet-derived growth factor receptor α (PDGFRα) is expressed frequently by tumor-associated stromal cells and by cancer cells in a subset of tumors. (elsevierpure.com)
Therapy studies were conducted using established PDGFRα-positive H1703 cells and PDGFRα-negative Calu-6, H1993, and A549 subcutaneous tumors in immunocompromised mice treated with vehicle, anti-PDGFRα mAbs, chemotherapy, or combination therapy. (elsevierpure.com)
Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. (nih.gov)
Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557-558 Deletion Mutations. (nih.gov)
Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. (ca.gov)
A constitutively activating mutation, cKit(V558Δ), causes gain-of-function phenotypes in mast cells and intestines, and gastrointestinal stromal tumors (GISTs) when heterozygous. (ca.gov)
People with a family history of GISTs (called familial GISTs) often have multiple tumors and additional signs or symptoms, including noncancerous overgrowth (hyperplasia) of other cells in the gastrointestinal tract and patches of dark skin on various areas of the body. (medlineplus.gov)
As a result, the proteins and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells and leads to the formation of tumors. (medlineplus.gov)
Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. (lu.se)
A total of 90.8% of the cases showed membranous PD-L2 expression in tumors, and 80.8% showed membranous PD-L2 expression in stromal tissue. (jcancer.org)
Programmed cell death-1 (PD-1) is mainly expressed on activated T cells and acts as an immune activation reaction of tumors after the combination of inhibitory receptor and ligand (PD-L1). (jcancer.org)
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
Gastrointestinal stromal tumors are tumors of the gastrointestinal tract derived from mesenchymal precursor cells in the gut wall. (msdmanuals.com)
Gastrointestinal stromal tumors (GISTs) result from mutations of a growth factor receptor gene, C-KIT . (msdmanuals.com)
Gastrointestinal stromal tumors (GISTs) result from mutations. (msdmanuals.com)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Stromal cells originate from multipotent mesenchymal stem cells. (wikipedia.org)
In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury? (wjgnet.com)
Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)

We studied the expression of programmed cell death protein 1 (PD-1) and its ligand (PD-L1) in TNBC. (nih.gov)
eCl Upon ligand-induced activation, receptors were internalized and found in intracellular vesicles. (cell-signaling-pathways.com)
This co-internalization was observed either with CXCL11 as the CXCR7-selective ligand (e-h) or with CXCL12 as YIL 781 the ligand for both receptors (i-l). (cell-signaling-pathways.com)
Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
When a ligand attaches (binds), the KIT or PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
Hematopoietic stem cell mobilizer binds to the CXCR4 chemokine receptor and inhibits the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1-alpha). (drugs.com)

Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
The A2B receptor (A2BR) can mediate adenosine-induced tumor proliferation, immunosuppression and angiogenesis. (unisa.it)
FGF2 produced by Bay60-6583-treated fibroblasts directly enhanced the proliferation of melanoma cells. (unisa.it)
Effects of anti-human (IMC-3G3) and anti-mouse (1E10) PDGFRα monoclonal antibodies (mAb) on proliferation and PDGFRα signaling were evaluated in lung cancer cell lines and mouse fibroblasts. (elsevierpure.com)
A sufficient supply of progenitor stem cells to facilitate epithelial cell proliferation is important for the cornea. (medscape.com)
Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
activation of NF-κB and costimulation of T cell proliferation. (biolegend.com)
During the course of folliculogenesis, growth is achieved by cell proliferation and formation of follicular fluid, whereas development involves cytodifferentiation of all the cells and tissues in the follicle. (glowm.com)
These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and survival. (medlineplus.gov)
Many studies have shown that MSCs possess immunosuppression abilities, such as the capacity to inhibit proliferation and functions of many immune cell types. (weizmann.ac.il)
Estrogens are female sex hormones that have genotoxic and proliferation-enhancing effects in cells. (helsinki.fi)
We show that marrow from human NHOs contains hematopoietic stem cell (HSC) niches, in which mesenchymal stromal cells (MSCs) and endothelial cells provide an environment supporting HSC maintenance, proliferation, and differentiation. (jci.org)
IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
CAFs provide cancer cells with nutrition and promote the proliferation, invasion and metastasis of cells ( 6 - 9 ). (spandidos-publications.com)
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met. (go.jp)

In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Mesenchymal stromal cells (MSCs) are widely spread in adult organisms. (weizmann.ac.il)
One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

Control constructs seeded with human dermal fibroblasts formed connective cells, but failed to form HMEs. (opioid-receptors.com)
IMC-3G3 inhibited PDGFRα activation and the growth of H1703 cells in vitro and tumor growth in vivo, but had no effect on PDGFRα-negative cell lines or mouse fibroblasts. (elsevierpure.com)
1E10 inhibited growth and PDGFRα activation of mouse fibroblasts, but had no effect on human cancer cell lines in vitro. (elsevierpure.com)
The role of exosomes collected by ultracentrifugation were also analyzed as mediators of p53 expression in cancer cells and APJ expression in fibroblasts. (spandidos-publications.com)
APJ expression in fibroblasts co‑cultured with p53‑suppressed colon cancer cells (HCT116 sh p53 cells) was significantly lower than in control colon cancer cells (HCT116 sh control cells). (spandidos-publications.com)
In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
APJ suppression from a specific microRNA in cancer cell‑derived exosomes induced CAF‑like properties in fibroblasts. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. (jci.org)
Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell-derived factor-1α and secondary lymphoid chemokine, respectively. (jci.org)
Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells. (jci.org)

Antigen-presenting cells accumulate near high endothelial venules to process soluble antigens. (wikipedia.org)
In an inflammatory state, lymphatic endothelial cells increase their surface adhesion molecules, and dendritic cells express a surface CCR7 receptor. (wikipedia.org)
Dendritic cells exhibit C-type lectin receptors (CLEC-2), which bind to gp38 on the surface of lymphatic endothelial cells. (wikipedia.org)
It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. (biolegend.com)
Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. (lu.se)

The ability of ROS to induce a sustained hypersumoylation response, or interfere with PR activity, was lost upon differentiation of HESCs into decidual cells. (warwick.ac.uk)
Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. (nih.gov)
Presentation] Macrophage-secreted Emilin2 Stimulates Chemotaxis and Differentiation in Stromal/Osteoblastic Cells. (nii.ac.jp)
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signalling and C/EBP. (mpg.de)
Cell Death and Differentiation. (monash.edu)
This makes their identification and differentiation from resident mesenchymal cells extremely difficult in the absence of further specific markers. (ersjournals.com)
We demonstrate that oncostatin M (OSM) produced by activated macrophages promotes osteoblastic differentiation and mineralization of human muscle-derived stromal cells surrounding NHOs. (jci.org)
IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. (thermofisher.com)
that regulate the differentiation and activation of these cells. (cdc.gov)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Avapritinib, another tyrosine kinase inhibitor, should be used as first-line therapy for patients with a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations. (msdmanuals.com)

These sinuses are cavities containing macrophages (specialised cells which help to keep the extracellular matrix in order). (wikipedia.org)
Beta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer. (mayoclinic.org)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
Furthermore, we found a positive correlation between stromal PD-L2 expression and the infiltration of CD68 + macrophages and CD4 + Foxp3 + Treg cells in NPC stromal tissues (Pearson correlation=0.181 and 0.098, respectively). (jcancer.org)
Our results provide strong evidence that macrophages contribute to NHO formation through the osteogenic action of OSM on muscle cells within an inflammatory context and suggest that OSM/OSMR could be a suitable therapeutic target. (jci.org)
A ) CD34 + cells from human neurogenic heterotopic ossification (NHO) were isolated using immunomagnetic cell separation and induced to differentiate into macrophages for 2 weeks in specific medium. (jci.org)
B ) Activated macrophages derived in vitro from NHO CD34 + cells stimulate NHO muscle-derived stromal cells (NHO-MDSCs). (jci.org)
C ) Mononuclear cells from human NHO marrows were analyzed by flow cytometry for mac markers, as in A . ( D ) Medium conditioned by activated macrophages from human NHO stimulate NHO-MDSC mineralization. (jci.org)
In that purpose, CD14 + monocytes/macrophages from human NHO were isolated using immunomagnetic cell separation and cultured with or without LPS (100 ng/ml) for 3 days. (jci.org)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)

Using primary cultures, we show that modest levels of reactive oxygen species (ROS) increase sumoylation in human endometrial stromal cells (HESCs), leading to enhanced modification and transcriptional inhibition of the progesterone receptor (PR). (warwick.ac.uk)
This inhibition was cell contact-dependent and soluble factor-independent, as indicated by trans-well experiments. (nih.gov)
In vivo, 1E10-targeted inhibition of murine PDGFRα reduced tumor growth as single-agent therapy in Calu-6 cells and enhanced the effect of chemotherapy in xenografts derived from A549 cells. (elsevierpure.com)
We conclude that stromal PDGFRα inhibition represents a means for enhancing control of lung cancer growth in some cases, independent of tumor cell PDGFRα expression. (elsevierpure.com)
Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
Inhibition of chemokine receptor 4, the receptor for the stem cell mobiliser stromal-derived factor-1, significantly prevented and reversed hypoxia-induced pulmonary hypertension in neonatal mice [ 13 ]. (ersjournals.com)

The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. (medlineplus.gov)
Studies in our laboratory have shown that some MSC functions are regulated by toll-like receptor (TLR) ligands. (weizmann.ac.il)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)

A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. (medlineplus.gov)

2007) referred to the Compact disc146 epitope (Most cancers Cell Adhesion Molecule, MCAM) as an antigen associated with self-renewing human osteoprogenitors capable of HME formation when transplanted subcutaneously in hydroxyapatite/tri-calcium phosphate (HA/TCP)/fibrin constructs [11]. (opioid-receptors.com)
Pre- hematopoietic and other cells, but the Duffy sence of one copy of the deleted CCR5 gene also antigen of erythrocytes (DARC) is the only influences the course of disease as the onset of member expressed on cells of erythroid lineage. (cdc.gov)
In addition, they act as antigen presenting cells and promote angiogenesis [ 8 ]. (ersjournals.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

Cultured adherent bone marrow stromal cells (BMSCs) are capable of forming ectopic hematopoietic microenvironments (HMEs) in immunodeficient mice. (opioid-receptors.com)
Bone marrow stromal cells (BMSC) are multipotent stem cells and are considered good candidates for cell restoration in injured brain tissue. (sld.cu)
Bone marrow stromal cells (BMSC) are adult stem cells with characteristics that make them an attractive candidate in cellular therapy for neurological diseases (1). (sld.cu)

Transplanted BMSCs that form HMEs also presumably secrete chemokines such as stromal-derived factor 1 alpha (SDF-1) that attract host-derived CD34-positive vascular and hematopoietic progenitors that then initiate hematopoiesis [14]. (opioid-receptors.com)
The molecular signaling systems (chemokines) that distribute lymphocytes to appropriate localities within the lymph node (T and B cell segregation) are also created by lymph node stromal cells. (wikipedia.org)
Lymphocytes have receptors for such chemokines. (wikipedia.org)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

Vinculin, a plasma protein, links fibers to talin, which is a cell membrane protein. (medscape.com)
Then, in order to obtain Waif1 antibodies mimicking Cthrc1 stimulation, we established monoclonal antibodies using soluble Waif1 protein and found osteoblastogenesis-stimulating antibodies by monitoring ALP activity of ST2 cells culturing with them. (nii.ac.jp)
Journal Article] WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation. (nii.ac.jp)
Say you have a G-protein coupled receptor (GPCR) of unknown function-with this assay you can determine whether it effects a stimulatory or inhibitory response, or induces necrosis under your experimental conditions, Dr. Jansson proposed as an example. (genengnews.com)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
Methods: Protein expression of tumour and/or stromal cell PDGFRα, PDGFRβ and PDGF-CC was evaluated in primary tumours (N = 489), synchronous lymph node metastases (N = 135) and asynchronous recurrences (N = 39) using immunohistochemistry in a prospectively maintained cohort of primary breast cancer patients included during 1999-2003. (lu.se)

Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications. (hindawi.com)

CXCL12 and its receptor CXCR4 are involved in angiogenesis and immune-suppression. (unisa.it)

Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
What Are Chemokine Receptors? (cdc.gov)

The expression of PD-L2 exhibited different spatial patterns among NPC tumor and stromal tissues. (jcancer.org)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
Cells Tissues Organs. (cancercentrum.se)

We further show that attenuated JNK signaling in decidual cells is a direct consequence of altered expression of key pathway modulators, including induction of MAP kinase phosphatase 1 (MKP1). (warwick.ac.uk)
Thus, JNK silencing uncouples ROS signaling from the SUMO conjugation pathway and maintains progesterone responses and cellular homeostasis in decidual cells under oxidative stress conditions imposed by pregnancy. (warwick.ac.uk)
Moreover, we showed that p75 NTR signaling is involved in the activation of the hypoxic signaling pathway and is also regulating glioma cell stemness and migration in hypoxia. (lu.se)
Purpose: The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. (lu.se)

Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)
Clarification of the mechanisms of insulin secretion and β-cell fate provides a basis for the understanding of diabetes and its better treatment. (go.jp)

The chemokine CXCL12 (stromal cell-derived factor-1, SDF-1) and its receptor CXCR4 play a major role in tumor initiation, promotion, progression and metastasis, especially for breast cancer cells. (cell-signaling-pathways.com)
Stimulation with the CXCR4- or CXCR7-selective non-peptide antagonists AMD3100 and CCX733 resulted not only in single internalization but partly also in co-internalization of the two receptors. (cell-signaling-pathways.com)
Our findings suggest that CXCR4 and CXCR7 closely YIL 781 interact in breast malignancy cells. (cell-signaling-pathways.com)
contamination by 4,6-diamidino-2-phenylindole (DAPI) staining and (CXCR4) and (CXCR7) fluorescent (secondary) antibodies in resting cells. (cell-signaling-pathways.com)

Our data reveal that Compact disc133 appearance recognizes a indigenous human being bone tissue marrow come/progenitor cell that provides rise to BMSCs able of developing the HME. (opioid-receptors.com)
Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
The fibrocyte is one of many populations of bone marrow-derived cells that can be detected in the peripheral blood and is considered to represent a mesenchymal progenitor cell [ 1 ]. (ersjournals.com)

Studies have been conducted to evaluate androgen receptor expression in cancer cells and most of the studies have concentrated on cancer epithelial cells and not cancer stromal cells. (journalcra.com)
Development of the prostate gland as well as development of prostatic cancer is closely associated with stromal-epithelial interactions and in the centre of these interactions stands the Androgen Receptor in both stromal and epithelial cells. (journalcra.com)
Results: In the epithelial cells Androgen Receptor expression declined as Gleason grade increased but this correlation was statistically not significant. (journalcra.com)
Conclusion: Androgen Receptor expression in stromal cells of prostatic carcinoma shows more pronounced decrease as the tumor dedifferentiates compared to Androgen Receptor expression in epithelial cells of prostatic carcinoma. (journalcra.com)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)
http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
Metalloproteinases are secreted as proenzymes by neutrophils infiltrating the wound, injured epithelial cells, and keratocytes. (medscape.com)

The basement membrane is also important for epithelial migration, and abnormalities in basement membrane structure, whether due to trauma (eg, recurrent erosion syndrome) or dystrophy (eg, basement membrane dystrophy), can lead to persistence of corneal epithelial defects and stromal ulceration. (medscape.com)
KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration and reprogramming to pluripotent embryonic germ cells (EGCs). (ca.gov)

This gene encodes a receptor tyrosine kinase. (nih.gov)

2021. Cell Reports Medicine. (biolegend.com)

The KIT and PDGFRA genes provide instructions for making receptor proteins that are found in the cell membrane of certain cell types. (medlineplus.gov)
PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)

The Transcription factor Aire (autoimmune regulator) that controls the expression of PTAs on mTEC cells in the thymus is only expressed at low levels by uncharacterized double negative stromal cells. (wikipedia.org)
Stromal PD-L1 expression was significantly associated with better DFS in multivariate analysis. (nih.gov)
In the stromal cells a decline in Androgen Receptor expression was also noted but this decline was more pronounced and statistically significant correlation of Androgen Receptor expression was noted between well differentiated carcinomas and moderately and poorly differentiated prostatic carcinomas. (journalcra.com)
Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression. (unisa.it)
We also identified that low expression cancer cell expression of VEGF-A and elevated expression of PDGF-AA were associated with response to stromal PDGFRα targeting. (elsevierpure.com)
The expression of insulin receptor substrate-1 (IRS-1) and its phosphorylated form, (p-IRS-1), as well as G6PC2, was determined through western blotting. (hindawi.com)
We evaluated cell stemness by using multiple functional assays in combination with stem cell marker expression analysis. (lu.se)
Understanding the clinical significance of PD-L2 expression, together with immune cell infiltration, might provide clues for biomarker screening in NPC immunotherapy. (jcancer.org)
High stromal expression of PD-L2 predicted favorable overall and disease-free survival of NPC patients and was negatively correlated with tumor size, recurrence or metastasis and clinical stage. (jcancer.org)
2 ] in 1994 and is defined by the expression of a variety of cell surface antigens, including the stem cell marker CD34, the pan-leukocyte marker CD45, and monocyte markers CD14 and CD11. (ersjournals.com)
The fibroblast-like nature of these cells is evidenced by their expression of collagen I, collagen II and vimentin. (ersjournals.com)
Cells were then analyzed by flow cytometry for expression of myeloid marker CD11b, monocyte/macrophage marker CD14, and M2 macrophage activation marker CD163 and CD206. (jci.org)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
Tumour cells displayed high expression of PDGFRα in 20%, and PDGF-CC in 21% of primary tumours, which correlated with the triple-negative subtype (TNBC). (lu.se)

Crosstalk LEC, lymphoid tissue inducer cells and mesenchymal stromal organizer cells initiate the formation of lymph nodes. (wikipedia.org)
1. To be able to describe the role of innate lymphoid cells (ILCs) in Date of Original Release: April 2014. (cdc.gov)
CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)
The term lymphoepithelioma has been used in cases in which the thymoma contains a large number of lymphoid cells. (medscape.com)
From the corticomedullary junction, the cells enter the medulla or circulate in the periphery to other lymphoid structures (ie, lymph nodes). (medscape.com)

Antigens are also present on the surface of dendritic cells. (wikipedia.org)
Due to this interaction, dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. (wikipedia.org)
Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). (nih.gov)

2019. Cell Stem Cell. (biolegend.com)

The primary role of lymph node stromal cells is structural. (wikipedia.org)
Lymphocytes leave the lymph node, as effector immune cells, via the efferent lymph vessels. (wikipedia.org)
This means immune cells may leave the lymph node along a chemokine gradient. (wikipedia.org)
Lymph node stromal cells express peripheral tissue-restricted antigens (PTAs) on their surface. (wikipedia.org)
Most lymph node stromal cells preferentially express DF1, an Aire-like transcription modulator. (wikipedia.org)
Tumour cell PDGFRα was significantly up-regulated in lymph node metastases and asynchronous recurrences. (lu.se)

These results provide evidence for Waif1 on stromal/osteoblastic cells as a receptor of osteoclast-secreted Cthrc1, and suggest that Waif1 serves an important coupling function of bone resorption to formation. (nii.ac.jp)

For example, Naive T cells express the CCR7 receptor for the chemokine CCL21. (wikipedia.org)

Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. (frontiersin.org)
Treatment of mice with AMD3100 reduced the number of CD31+ cells induced by Bay60-6583. (unisa.it)
Recent studies demonstrated that, in mice, activated IL-17-secreting CD4 + helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). (biolegend.com)
Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP+ cells to appear in active fibrotic lesions, while only a few GFP+ cells could be identified in control lungs. (jci.org)
Flow-cytometric analysis of lung cells confirmed the BLM-induced increase in GFP+ cells in chimera mice and revealed a significant increase in GFP+ cells that also express type I collagen. (jci.org)
A further study in newborn mice exposed to hypoxia showed increased accumulation of bone marrow-derived cells associated with pulmonary hypertension [ 12 ]. (ersjournals.com)
The key role of OSM was confirmed using an experimental model of NHO in mice defective for the OSM receptor (OSMR). (jci.org)

Only a few follicles in the human ovary survive to complete the cytodifferentiation process, with 99.9% dying by a programmed cell death mechanism called apoptosis. (glowm.com)
thus, those cells that fail to receive a signal (ie, do not recognize self) die by apoptosis or become inactive. (medscape.com)

This leads to mobilization of hematopoietic stem cells to the peripheral blood. (drugs.com)
The hematopoietic stem cells (CD34+ cells) are collected from the peripheral blood and used for autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma . (drugs.com)
High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. (thermofisher.com)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
We sought to determine the effect of targeting stromal PDGFRα in preclinical lung tumor xenograft models (human tumor, mouse stroma). (elsevierpure.com)
We further demonstrated successful examples of multiple targeting including chromosomal deletions in human cells using the all-in-one CRISPR/Cas9 vectors constructed with our novel system. (nature.com)
Similarly, CD34+ cells can be identified in human scar tissue, suggesting that these cells may contribute to tissue remodelling and repair [ 5 ]. (ersjournals.com)

Semi-quantification of receptor internalization was achieved by labeling the glycocalyx of the cell surface with WGA (a lectin that binds to sialic acid and phosphorylated Erk, control with antagonists alone). (cell-signaling-pathways.com)

The lymph tissue in the lymph nodes consists of immune cells (95%), for example lymphocytes, and stromal cells (1% to 5%) The genesis of lymph nodes begins within the blood and the lymphatic system. (wikipedia.org)
Full-face sections from 136 TNBC cases without neoadjuvant therapy between 2004 and 2013 were stained and evaluated for immune cell PD-1 staining and stromal or tumoral PD-L1 staining using the H-score (staining percentage × intensity). (nih.gov)
TLRs are abundant receptors implicated in many functions, however they are mostly studied in the immune system. (weizmann.ac.il)
TLRs are expressed on immune cells, where they recognize pathogenic patterns. (weizmann.ac.il)
The immune cell markers CD4, FOXP3 and CD68 were also stained and quantified. (jcancer.org)
PD-L2 expressed on stromal cells might play a role in the regulation of NPC progression, and involve in immune activation in the tissue microenvironment and have an independent good prognosis for NPC patients. (jcancer.org)

The primary purpose of this article is to highlight the pathogenesis of noninfectious stromal ulceration. (medscape.com)
Dysfunction of the β-cells and/or a decrease in the β-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. (go.jp)

Genome editing using clustered regularly-interspaced short palindromic repeats (CRISPR)/Cas9 is an easy and efficient strategy for the generation of gene-modified cells and organisms 1 , 2 . (nature.com)

Finally, CAFs promote cancer progression and act in cancer cell drug resistance. (spandidos-publications.com)

In vitro, these cells have a multipotent phenotype, which manifests as the ability to differentiate into several mesodermal lineages, especially adipocytes, chondrocytes and osteoblasts. (weizmann.ac.il)

The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
The aim of this thesis was to evaluate how microenvironmental cues affect the interactions between the tumor microenvironment and glioma stem-like cells in glioblastoma. (lu.se)

Without activation, receptors were scattered alone or lay in close proximity at the cell surface. (cell-signaling-pathways.com)
As seen best in immunofluorescence, CXCL12 activation initially resulted in a mostly individual internalization of both receptors (5?min, Fig.?2c, place) as detected by individual red and green dots and a lower frequency of yellow (merged fluorescence) dots. (cell-signaling-pathways.com)
TP53‑deficiency in cancer cells is associated with robust stromal activation. (spandidos-publications.com)

[ 4 ] MG is caused by autoantibodies to postsynaptic nicotinic acetylcholine receptors (anti-AChRs) at the neuromuscular junction, causing weakness of skeletal muscles. (medscape.com)

It is widely recognized that the accumulation of various harmful genetic alterations in normal cells may induce malignant cancer cells ( 1 ). (spandidos-publications.com)

Anatomy43

Organisms7

Diseases14

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes36

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Tumors18

Mesenchymal stem6

Ligand6

Proliferation15

MSCs9

Fibroblasts12

Endothelial5

Differentiation10

Platelet-derived1

Macrophages10

Inhibition6

Ligands4

Gastrointestinal-strom1

Antigen5

Bone marro3

Chemokines4

Protein6

Umbilical cord mesenchymal1

Angiogenesis1

Chemokine Receptors2

Tissues3

Pathway4

Secretion2

CXCR44

Progenitor3

Epithelial cells8

Migration2

Tyrosine1

20211

Proteins4

Progesterone receptor1

Expression14

Lymphoid6

Dendritic cells3

Stem cell1

Lymph node6

Osteoblastic1

CCR71

Mice8

Apoptosis2

Peripheral3

Human5

Binds1

Immune6

Pathogenesis2

Organisms1

Progression1

Adipocytes1

Tumor microenvironment2

Activation3

Skeletal1

Induce1